The Hidden World Of Protein Aggregation

Author : Anonim
Publisher : Elsevier
Page : 530 pages
File Size : 51,7 Mb
Release : 2024-08-01
Category : Science
ISBN : 9780443293412

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The Hidden World of Protein Aggregation by Anonim Pdf

The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more. Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation Describes functional amyloids and their biotechnological applications

Author : Douglas A. Stein
Publisher : Nova Biomedical Books
Page : 0 pages
File Size : 41,5 Mb
Release : 2011
Category : Cell aggregation
ISBN : 1617618152

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Protein Aggregation by Douglas A. Stein Pdf

Protein aggregation is the aggregation of mis-folded proteins, and is thought to be responsible for many degenerative diseases, such as Alzheimer's. This book presents current research from across the globe in the study of protein aggregation, including the processes of protein aggregation induced by freezing and lyophilization; functional amyloids; thermally induced aggregation of a model system protein - insulin; the aggregation of albumin; synucleins implicated in neurodegenerative diseases and some forms of cancer; yeast protein aggregates; and the folding and aggregation features of proteins.

Author : Vladimir N. Uversky,Anthony Fink
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 52,9 Mb
Release : 2007-11-24
Category : Science
ISBN : 9780387259192

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Protein Misfolding, Aggregation and Conformational Diseases by Vladimir N. Uversky,Anthony Fink Pdf

Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.

Author : Yuan Jian-min,Zhou Huan-xiang
Publisher : World Scientific
Page : 328 pages
File Size : 48,9 Mb
Release : 2017-06-02
Category : Science
ISBN : 9789813202399

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Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-assembly Of Amyloidogenic Peptides by Yuan Jian-min,Zhou Huan-xiang Pdf

This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.

Author : Bharat Bhushan,Harald Fuchs
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 53,5 Mb
Release : 2006-04-28
Category : Technology & Engineering
ISBN : 9783540269106

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Applied Scanning Probe Methods III by Bharat Bhushan,Harald Fuchs Pdf

The Nobel Prize of 1986 on Sc- ning Tunneling Microscopy sig- led a new era in imaging. The sc- ning probes emerged as a new i- trument for imaging with a pre- sion suf?cient to delineate single atoms. At ?rst there were two – the Scanning Tunneling Microscope, or STM, and the Atomic Force Mic- scope, or AFM. The STM relies on electrons tunneling between tip and sample whereas the AFM depends on the force acting on the tip when it was placed near the sample. These were quickly followed by the - gneticForceMicroscope,MFM,and the Electrostatic Force Microscope, EFM. The MFM will image a single magnetic bit with features as small as 10nm. With the EFM one can monitor the charge of a single electron. Prof. Paul Hansma at Santa Barbara opened the door even wider when he was able to image biological objects in aqueous environments. At this point the sluice gates were opened and a multitude of different instruments appeared. There are signi?cant differences between the Scanning Probe Microscopes or SPM, and others such as the Scanning Electron Microscope or SEM. The probe microscopes do not require preparation of the sample and they operate in ambient atmosphere, whereas, the SEM must operate in a vacuum environment and the sample must be cross-sectioned to expose the proper surface. However, the SEM can record 3D image and movies, features that are not available with the scanning probes.

Author : Anonim
Publisher : Academic Press
Page : 320 pages
File Size : 45,5 Mb
Release : 2017-02-01
Category : Science
ISBN : 9780128122525

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Early Stage Protein Misfolding and Amyloid Aggregation by Anonim Pdf

Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists. Provides comprehensive reviews and current advances Presents a wide range of perspectives on specific subjects Includes valuable reference material for advanced undergraduates, graduate students, and professional scientists

Author : Carlos Henrique Meneses,Diogo Neves Proença,Marcia Soares Vidal ,German Andres Estrada-Bonilla
Publisher : Frontiers Media SA
Page : 194 pages
File Size : 51,9 Mb
Release : 2024-05-21
Category : Science
ISBN : 9782832549278

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Plant-Bacteria Association and Symbiosis by Carlos Henrique Meneses,Diogo Neves Proença,Marcia Soares Vidal ,German Andres Estrada-Bonilla Pdf

As a result of the environmental impacts associated with chemical fertilizer misuse, society has turned its attention to alternative and sustainable forms of plant nutrition. By providing substances that would otherwise be scarce, plant growth-promoting bacteria (PGPBs) can influence the availability of nutrients, directly affecting plants' metabolism. In addition to fixing nitrogen, and solubilizing phosphorus, and iron, they also produce hormones such as auxins, gibberellins, cytokinin's, and ethylene). Studies with PGPB around the world must be directed towards biological control and growth promotion integrated into a sustainable management system. Gradually, the problems identified in research with biological control are being solved. However, erratic results regarding the bacterization of cultures frustrate researchers and result from a lack of understanding of plant-microorganism interactions dynamics under various environmental conditions.

Author : Alberto Espay,Benjamin Stecher
Publisher : Cambridge University Press
Page : 179 pages
File Size : 43,7 Mb
Release : 2020-07-09
Category : Medical
ISBN : 9781108744621

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Brain Fables by Alberto Espay,Benjamin Stecher Pdf

With no biological boundaries between neurodegenerative diseases as defined today, Brain Fables offers a blueprint for precision medicine.

Author : Akihiko Takashima,Benjamin Wolozin,Luc Buee
Publisher : Springer Nature
Page : 416 pages
File Size : 51,7 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9789813293588

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Tau Biology by Akihiko Takashima,Benjamin Wolozin,Luc Buee Pdf

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Author : Gianfranco Menestrina,M. Dalla Sera
Publisher : CRC Press
Page : 360 pages
File Size : 45,6 Mb
Release : 2003-01-30
Category : Medical
ISBN : 9780203986646

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Pore-forming Peptides and Protein Toxins by Gianfranco Menestrina,M. Dalla Sera Pdf

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has

Author : David B. Teplow
Publisher : Academic Press
Page : 218 pages
File Size : 42,7 Mb
Release : 2018-10-16
Category : Science
ISBN : 9780128162361

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Progress in Molecular Biology and Translational Science by David B. Teplow Pdf

Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Author : Dmitry Kurouski
Publisher : BoD – Books on Demand
Page : 244 pages
File Size : 41,7 Mb
Release : 2019-08-07
Category : Medical
ISBN : 9781789853810

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Amyloid Diseases by Dmitry Kurouski Pdf

Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?

Author : James B. Nardi
Publisher : Princeton University Press
Page : 312 pages
File Size : 40,7 Mb
Release : 2023-02-07
Category : Nature
ISBN : 9780691238159

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The Hidden Company That Trees Keep by James B. Nardi Pdf

A spectacularly illustrated journey into the intimate communities that native trees share with animals, insects, fungi, and microbes You can tell a lot about a tree from the company it keeps. James Nardi guides you through the innermost unseen world that trees share with a wondrous array of creatures. With their elaborate immune responses, trees recruit a host of allies as predators and parasites to defend against uninvited advances from organisms that chew on leaves, drain sap, and bore into wood. Microbial life thrives in the hidden spaces of leaf scales, twigs, and bark, while birds, mammals, and insects benefit from the more visible resources trees provide. In return, animals help with pollination, seed dispersal, and recycling of nutrients. The Hidden Company That Trees Keep blends marvelous storytelling with beautiful illustrations and the latest science to reveal how the lives of trees are intertwined with those of their diverse companions. Features a wealth of richly detailed drawings accompanied by breathtaking images of microscopic landscapes on leaf, bark, and root surfaces Includes informative fact boxes Draws on new discoveries in biology and natural history Written by one of the world’s leading naturalists

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9789814470490

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Molecules: Nucleation, Aggregation and Crystallization by Anonim Pdf

Author : Ridge Shinn,Lynne Pledger
Publisher : Chelsea Green Publishing
Page : 225 pages
File Size : 46,6 Mb
Release : 2022-11-11
Category : Technology & Engineering
ISBN : 9781645021254

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Grass-Fed Beef for a Post-Pandemic World by Ridge Shinn,Lynne Pledger Pdf

*With a foreword by Gabe Brown, bestselling author of Dirt to Soil How can we learn from our mistakes and pave a way for sustainable, nutritious, local meat? The COVID-19 pandemic exposed the vulnerabilities of our globalized food system and highlighted the desperate need for local and regional supplies of healthy meat. We must replace corn-based feedlots, which are responsible for significant climate emissions, nitrogen pollution, and animal suffering. Grass-Fed Beef for a Post-Pandemic World outlines a hopeful path out of our broken food system via regional networks of regeneratively produced meat. In 2017, Ridge Shinn and Lynne Pledger went to market with Big Picture Beef, a company that partners with farmers across the Northeast to increase access to wholesale markets while promoting holistic grazing management techniques. The result? Increased health benefits for consumers, the environment, and livestock. In Grass Fed-Beef for a Post-Pandemic World, you’ll find information assembled from the fields of ecology, climate science, nutrition, and animal welfare, along with on-the-farm stories from Ridge’s travels as a consultant all over the United States and abroad. You’ll discover how regenerative grazing can: restore degraded farmland protect against droughts and floods increase biodiversity combat climate change by reducing emissions and sequestering carbon contribute to regional economic development produce nutrient-dense, healthy meat for consumers Grass-Fed Beef for a Post-Pandemic World is not just for beef producers, but for anyone wondering how our farmers and ranchers can raise cattle while also caring for the local and global environment.