Tau Biology

Author : Akihiko Takashima,Benjamin Wolozin,Luc Buee
Publisher : Springer Nature
Page : 416 pages
File Size : 54,8 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9789813293588

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Tau Biology by Akihiko Takashima,Benjamin Wolozin,Luc Buee Pdf

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Author : Anonim
Publisher : Academic Press
Page : 342 pages
File Size : 46,8 Mb
Release : 2017-08-29
Category : Science
ISBN : 9780128124994

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Methods in Tau Cell Biology by Anonim Pdf

Methods in Tau Cell Biology, Volume 141, the latest release in the Methods in Cell Biology series, looks at methods involved in tau cell biology. Edited by leaders in the field, this volume provides proven, state-of-art techniques and relevant historical background and theory that aids researchers with tactics for efficient design and effective implementation of experimental methodologies. Topics of note in this updated volume include sections on Recombinant tau expression and purification, In vitro MT dynamics and MT ends, Methods related to investigating tau structure and MT bundling, Neurite outgrowth and retraction, and Methods related to studying tau fragmentation. Covers sections on Tau Cell Biology Written by experts in the field of cell biology Includes cutting-edge materials

Author : Caroline Smet-Nocca
Publisher : Springer Nature
Page : 604 pages
File Size : 51,7 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9781071636299

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Tau Protein by Caroline Smet-Nocca Pdf

Author : Antonio Tito Fojo
Publisher : Springer Science & Business Media
Page : 629 pages
File Size : 50,7 Mb
Release : 2009-01-14
Category : Medical
ISBN : 9781597453363

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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology by Antonio Tito Fojo Pdf

This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

Author : Sonia Do Carmo,A. Claudio Cuello,Maria Grazia Spillantini
Publisher : Frontiers Media SA
Page : 268 pages
File Size : 43,8 Mb
Release : 2021-11-12
Category : Science
ISBN : 9782889716258

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Tau Pathology in Neurological Disorders by Sonia Do Carmo,A. Claudio Cuello,Maria Grazia Spillantini Pdf

Author : R.J. Castellani
Publisher : IOS Press
Page : 506 pages
File Size : 42,7 Mb
Release : 2020-04-24
Category : Medical
ISBN : 9781643680651

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Handbook of Traumatic Brain Injury and Neurodegeneration by R.J. Castellani Pdf

Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.

Author : Christian Haass
Publisher : CRC Press
Page : 330 pages
File Size : 41,6 Mb
Release : 2014-04-21
Category : Science
ISBN : 9781482283457

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Molecular Biology of Alzheimer's Disease by Christian Haass Pdf

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Author : Andrzej Stanisław Cieplak
Publisher : Springer Nature
Page : 673 pages
File Size : 53,7 Mb
Release : 2022-10-30
Category : Science
ISBN : 9781071625972

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Protein Aggregation by Andrzej Stanisław Cieplak Pdf

The volume details techniques, methods, and conceptual developments to further the study of protein aggregation with emphasis on the pleiomorphic proteins implicated in etiology of neurodegeneration. Chapters guide readers through in vitro and in vivo studies of fibrillization and liquid-liquid phase separation processes, and offer a comprehensive account of the state-of-art of structural studies of protein aggregation. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Aggregation: Methods and Protocols aims to be useful and practical guide to new researchers and experts looking to expand their knowledge.

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer Nature
Page : 607 pages
File Size : 52,6 Mb
Release : 2019-11-04
Category : Science
ISBN : 9783030231583

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Heat Shock Protein 90 in Human Diseases and Disorders by Alexzander A. A. Asea,Punit Kaur Pdf

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Author : Ralph A. Nixon,Aidong Yuan
Publisher : Springer Science & Business Media
Page : 775 pages
File Size : 41,7 Mb
Release : 2011-02-04
Category : Medical
ISBN : 9781441967879

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Cytoskeleton of the Nervous System by Ralph A. Nixon,Aidong Yuan Pdf

This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Author : David B. Teplow
Publisher : Academic Press
Page : 499 pages
File Size : 49,8 Mb
Release : 2012-04-13
Category : Medical
ISBN : 9780123858832

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Molecular Biology of Neurodegenerative Diseases by David B. Teplow Pdf

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson's, Alzheimer's and Huntington's disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Jared Kreiner,Graham Wrightson
Publisher : Cambridge Scholars Publishing
Page : 327 pages
File Size : 40,7 Mb
Release : 2024-04-03
Category : History
ISBN : 9781527570405

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Ancient Warfare, Volume II by Jared Kreiner,Graham Wrightson Pdf

This volume demonstrates the wide array of topics in ancient warfare currently studied by researchers around the world. Arranged chronologically in Greek and Roman history sections, the book takes readers through all manner of current research topics on ancient warfare, from traditional battle narratives or strategic analyses of campaigns, through the logistical considerations of armies in the field, to the ideology of women in war and mythology. The study of ancient war deals with a myriad of different topics and deals with themes in all types of history: social, cultural, economic, religious, literary, numismatical, epigraphical, ethnographical, topographical, prosopographical, and mythical, as well as the usual political and military. The study of ancient war is a field that is growing in popularity and continues to surprise us with many innovative new ideas, as shown in this collection of papers by established academics and current graduate students.

Author : Renee D. Wegrzyn,Alan S. Rudolph
Publisher : CRC Press
Page : 301 pages
File Size : 40,9 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9781439827093

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Alzheimer's Disease by Renee D. Wegrzyn,Alan S. Rudolph Pdf

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the c

Author : Robert D. E. Sewell
Publisher : CRC Press
Page : 596 pages
File Size : 47,8 Mb
Release : 2007-12-03
Category : Medical
ISBN : 9781420007145

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Protein Misfolding in Neurodegenerative Diseases by Robert D. E. Sewell Pdf

Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.

Author : Illana Gozes,Joseph Levine
Publisher : Academic Press
Page : 322 pages
File Size : 40,6 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128140383

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Neuroprotection in Autism, Schizophrenia and Alzheimer's disease by Illana Gozes,Joseph Levine Pdf

Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer’s disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry