The Hippocampus From Cells To Systems

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The Hippocampus from Cells to Systems

Deborah E. Hannula,Melissa C. Duff
The Hippocampus from Cells to Systems Book PDF

Author : Deborah E. Hannula,Melissa C. Duff
Publisher : Springer
Page : 589 pages
File Size : 48,8 Mb
Release : 2017-03-01
Category : Medical
ISBN : 9783319504063

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The Hippocampus from Cells to Systems by Deborah E. Hannula,Melissa C. Duff Pdf

The hippocampus has long been considered a critical substrate in the neurobiology, neuropsychology, and cognitive neuroscience of memory. Over the past few decades, a number of ground-breaking theoretical and methodological advances have radically enhanced our understanding of the structure and function of the hippocampus and revolutionized the neuroscientific study of memory. Cutting across disciplines and approaches, these advances offer novel insights into the molecular and cellular structure and physiology of the hippocampus, the role of hippocampus in the formation, (re)consolidation, enhancement, and retrieval of memory across time and development, and permit investigators to address questions about how the hippocampus interacts, functionally and anatomically, with other neural systems in service of memory. In addition, recent investigations also suggest that the mechanistic properties and functional processing features of the hippocampus permit broader contributions to cognition, beyond memory, to the domains of attention, decision-making, language, social cognition, and a variety of other capacities that are critical for flexible cognition and behavior. These advances have profound implications for the neurobiology and cognitive neuroscience of hippocampus dependent cognition and for the numerous psychiatric and neurological diseases and disorders for which hippocampal pathology is a hallmark such as Alzheimer’s disease and schizophrenia. The goal of this book is to bring together in a single source an integrated review of these advances providing state of the art treatment on the structure and function of the hippocampus. Contributors will examine the hippocampus from a variety of levels (from cells to systems) using a wide range of methods (from neurobiological approaches in non-human animals to neuroimaging and neuropsychological work in humans).

Discovering the Brain

National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Discovering the Brain Book PDF

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 45,8 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Micro-, Meso- and Macro-Dynamics of the Brain

György Buzsáki,Yves Christen
Micro Meso and Macro Dynamics of the Brain Book PDF

Author : György Buzsáki,Yves Christen
Publisher : Springer
Page : 181 pages
File Size : 52,5 Mb
Release : 2016-05-02
Category : Medical
ISBN : 9783319288024

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Micro-, Meso- and Macro-Dynamics of the Brain by György Buzsáki,Yves Christen Pdf

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Brain Organization and Memory

James L. McGaugh,Norman M. Weinberger,Gary Lynch
Brain Organization and Memory Book PDF

Author : James L. McGaugh,Norman M. Weinberger,Gary Lynch
Publisher : Oxford University Press
Page : 428 pages
File Size : 42,9 Mb
Release : 1992-06-25
Category : Psychology
ISBN : 9780195360257

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Brain Organization and Memory by James L. McGaugh,Norman M. Weinberger,Gary Lynch Pdf

This edited volume summarizes recent findings of leading researchers investigating the brain systems that underlie memory. The book reviews recent progress in understanding forms of memory in animals and humans and the interaction of cortical and subcortical systems in the regulation of memory. Special emphasis is given to the development of neural network models that attempt to link cells to systems in the representation of memory. The book will be an invaluable source for cognitive psychologists, neuroscientists, and students interested in this active and exciting area of research.

The Hippocampus

Philippe Taupin
The Hippocampus Book PDF

Author : Philippe Taupin
Publisher : Nova Publishers
Page : 156 pages
File Size : 41,5 Mb
Release : 2007
Category : Medical
ISBN : 1600219144

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The Hippocampus by Philippe Taupin Pdf

The hippocampus , the Greek word for seahorse, is one of the most fascinating and intriguing regions of the mammalian brain. It is a bilateral incurved seahorse-shaped structure of the cerebral cortex. The hippocampus has a highly distinctive morphology. It is composed of two regions, the dentate gyrus (DG) and the Cornu Ammonis (CA). The nerve cells of the main layer of the DG and CA regions, the granule cells and pyramidal cells respectively, are organised in a tri-synaptic lamellaire circuit. The granule and pyramidal cells are glutamatergic excitatory. The granule cells elicit unique histological, biochemical, developmental, physio- and pathological features. The hippocampus is also an area of the brain that elicits a high degree of plasticity, like synaptic and phenotypic plasticity. It is also one of the few regions of the brain where neurogenesis, the generation of new nerve cells, occurs throughout adulthood. The hippocampus is involved in physio-and pathological processes, like learning and memory.

Hippocampal Place Fields

Sheri J.Y. Mizumori
Hippocampal Place Fields Book PDF

Author : Sheri J.Y. Mizumori
Publisher : Oxford University Press
Page : 431 pages
File Size : 54,6 Mb
Release : 2008-02-26
Category : Medical
ISBN : 9780198043454

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Hippocampal Place Fields by Sheri J.Y. Mizumori Pdf

Data from neuropsychological and animal research suggest that the hippocampus plays a pivotal role in two relatively different areas: active navigation, as well as episodic learning and memory. Recent studies have attempted to bridge these disparate accounts of hippocampal function by emphasizing the role that hippocampal place cells may play in processing the spatial contextual information that defines situations in which learned behaviors occur. A number of established laboratories are currently offering complementary interpretations of place fields, and this book will present the first common platform for them. Bringing together research from behavioral, genetic, physiological, computational, and neural-systems perspectives will provide a thorough understanding of the extent to which studying place-field properties has informed our understanding of the neural mechanisms of hippocampus-dependent memory. Hippocampal Place Fields: Relevance to Learning and Memory will serve as a valuable reference for everyone interested in hippocampal function.

Memory, Amnesia, and the Hippocampal System

Neal J. Cohen,Howard Eichenbaum
Memory Amnesia and the Hippocampal System Book PDF

Author : Neal J. Cohen,Howard Eichenbaum
Publisher : MIT Press
Page : 348 pages
File Size : 41,8 Mb
Release : 1993
Category : Amnesia
ISBN : 9780262032032

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Memory, Amnesia, and the Hippocampal System by Neal J. Cohen,Howard Eichenbaum Pdf

In this text, Neal J. Cohen and Howard Eichenbaum bring together converging findings from neuropsychology, neuroscience and cognitive science that provide the critical clues and constraints for developing a more comprehensive understanding of memory. Specifically, they offer a cognitive neuroscience theory of memory that accounts for the nature of memory impairment exhibited in human amnesia and animal models of amnesia, that specifies the functional role played by the hippocampal system in memory, and that provides further understanding of the componential structure of memory.

Mechanisms of Memory

J. David Sweatt
Mechanisms of Memory Book PDF

Author : J. David Sweatt
Publisher : Academic Press
Page : 362 pages
File Size : 45,8 Mb
Release : 2009-09-28
Category : Psychology
ISBN : 0080959199

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Mechanisms of Memory by J. David Sweatt Pdf

This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

The Hippocampus

Robert Isaacson,Karl H. Pribram
The Hippocampus Book PDF

Author : Robert Isaacson,Karl H. Pribram
Publisher : Springer
Page : 448 pages
File Size : 54,7 Mb
Release : 1975
Category : Medical
ISBN : UVA:X001391287

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The Hippocampus by Robert Isaacson,Karl H. Pribram Pdf

These books are the result of a conviction held by the editors, authors, and publisher that the time is appropriate for assembling in one place information about functions of the hippocampus derived from many varied lines of research. Because of the explosion of research into the anatomy, physiology, chemistry, and behavioral aspects of the hip pocampus, some means of synthesis of the results from these lines of research was called for. We first thought of a conference. In fact, officials in the National Institute of Mental Health suggested we organize such a conference on the hippocampus, but after a few tentative steps in this direction, interest at the federallevel waned, probably due to the decreases in federal support for research in the basic health sciences so keenly feit in recent years. However, the editors also had co me to the view that conferences are mainly valuabIe to the participants. The broad range of students (of all ages) of brain behavior relations do not profit from conference proceedings unless the proceedings are subsequently published. Furthermore, conferences dealing with the functional character of organ systems approached from many points of view are most successful after participants have become acquainted with each other's work. Therefore, we believe that a book is the best format for disseminating information, and that its publication can be the stimulus for many future conferences.

Space,Time and Memory in the Hippocampal Formation

Dori Derdikman,James J. Knierim
Space Time and Memory in the Hippocampal Formation Book PDF

Author : Dori Derdikman,James J. Knierim
Publisher : Springer
Page : 571 pages
File Size : 50,6 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783709112922

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Space,Time and Memory in the Hippocampal Formation by Dori Derdikman,James J. Knierim Pdf

The discovery of new cell types, such as grid and time cells, in the hippocampus has been accompanied by major anatomical and theoretical insights in the recent years. This book provides comprehensive, up-to-date information about the hippocampal formation and especially the neural basis of episodic memory, spatial location (the formation of the cognitive map) and temporal representation. The first part of the book describes the information flow from pre-hippocampal areas into the hippocampus, the second part discusses the different types of hippocampal processing and finally, the third part depicts the influence that the hippocampal processing has on other brain structures that are perhaps more closely tied to explicit cognitive or behavioral output. This book is intended for neuroscientists, especially for those who are involved in research on the hippocampus, as well as for behavioral scientists and neurologists.

Hippocampus

Douglas D. Burman
Hippocampus Book PDF

Author : Douglas D. Burman
Publisher : BoD – Books on Demand
Page : 210 pages
File Size : 51,6 Mb
Release : 2023-07-19
Category : Medical
ISBN : 9781837687121

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Hippocampus by Douglas D. Burman Pdf

Ever since side effects from bilateral hippocampectomy were identified in Henry Molaison (patient “HM”) during the 1950s, a critical role of the hippocampus has been recognized in the formation of declarative episodic memories. Other cognitive functions have since been proposed, such as a role in navigation, but memory has often been suggested to explain hippocampal involvement. Proving a distinct functional role in cognition is difficult, as memory can be implicated in most cognitive activities. Even when a behavior relies on memory, however, the functionality of the hippocampus extends far beyond, especially evident during activities requiring interactions between cognitive systems. Relational memory is supported by hippocampal connections with widespread regions of the cortex; these interconnections also play a fundamental role in children’s writing abilities and expertise in musical performance. Besides enhancing individual lives, such activities can play a vital role in sustaining cultural values across generations. Interactions with the environment that do not directly depend on mnemonic activity can affect plasticity in hippocampal connections, modified through natural chemicals, pharmacological drugs, and non-pharmacological behaviors. Navigational properties of the hippocampal system are not limited to memory, containing the same navigational elements as our Global Positional System (GPS). Even cognitive deficits arising from hippocampal lesions in “HM” were not limited to memory, as they included deficits in understanding cognitive relationships available in visual scenes, novel sentence contexts, and humorous situations. This book shows an expansive role of the hippocampus in cognition that goes beyond its recognized role in generating new episodic memories.

The Hippocampus in Clinical Neuroscience

K. Szabo,M.G. Hennerici
The Hippocampus in Clinical Neuroscience Book PDF

Author : K. Szabo,M.G. Hennerici
Publisher : Karger Medical and Scientific Publishers
Page : 172 pages
File Size : 49,5 Mb
Release : 2014-04-23
Category : Psychology
ISBN : 9783318025682

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The Hippocampus in Clinical Neuroscience by K. Szabo,M.G. Hennerici Pdf

The hippocampus is one of the most intriguing structures of the human brain. Damage to this part causes symptoms ranging from transient disorders accompanied by tiny lesions to severely debilitating cognitive disorders with marked tissue loss. This publication provides a predominantly clinical approach to the complex workings of the hippocampus from different perspectives, ranging from basic principles to specific diseases. The first part of the book summarizes current knowledge regarding the structure and physiology of the hippocampus and establishes the ties to basic neuroscience. The second part deals with the function and assessment of the human hippocampus, including memory function, neuropsychological measures, and conventional and functional imaging studies. The chapters of the third part are devoted to the hippocampus in neurological disorders, e.g. the interaction between stress and memory function, and the pathological conditions of common as well as selected rare neurological diseases affecting the hippocampus. The book is highly recommended to clinical neurologists who wish to gain a broad understanding of this complex and fascinating organ in terms of basic principles, modern imaging findings, and specific diseases.

Neuronal Networks of the Hippocampus

Roger D. Traub,Richard Miles
Neuronal Networks of the Hippocampus Book PDF

Author : Roger D. Traub,Richard Miles
Publisher : Cambridge University Press
Page : 0 pages
File Size : 49,9 Mb
Release : 2008-05-29
Category : Medical
ISBN : 0521063310

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Neuronal Networks of the Hippocampus by Roger D. Traub,Richard Miles Pdf

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.

Beyond the Cognitive Map

A. David Redish
Beyond the Cognitive Map Book PDF

Author : A. David Redish
Publisher : MIT Press
Page : 452 pages
File Size : 42,8 Mb
Release : 1999
Category : Animal navigation
ISBN : 0262181940

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Beyond the Cognitive Map by A. David Redish Pdf

There are currently two major theories about the role of the hippocampus, a distinctive structure in the back of the temporal lobe. One says that it stores a cognitive map, the other that it is a key locus for the temporary storage of episodic memories. A. David Redish takes the approach that understanding the role of the hippocampus in space will make it possible to address its role in less easily quantifiable areas such as memory. Basing his investigation on the study of rodent navigation--one of the primary domains for understanding information processing in the brain--he places the hippocampus in its anatomical context as part of a greater functional system. Redish draws on the extensive experimental and theoretical work of the last 100 years to paint a coherent picture of rodent navigation. His presentation encompasses multiple levels of analysis, from single-unit recording results to behavioral tasks to computational modeling. From this foundation, he proposes a novel understanding of the role of the hippocampus in rodents that can shed light on the role of the hippocampus in primates, explaining data from primate studies and human neurology. The book will be of interest not only to neuroscientists and psychologists, but also to researchers in computer science, robotics, artificial intelligence, and artificial life.

The Hippocampus

R.L. Isaacson,K.H. Pribram
The Hippocampus Book PDF

Author : R.L. Isaacson,K.H. Pribram
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 41,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781461580249

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The Hippocampus by R.L. Isaacson,K.H. Pribram Pdf

The current volumes of The Hippocampus reflect the prodigious amount of work aimed at discovering the functions of this structure over the past decade. The hippocampus ideally lends itself to two types of study: (1) because of its regular and relatively simple cytoarchitecture, it can serve as a model for cortical processing in general, and (2) because of its size and central location, the role of the hippocampus in the total ecology of brain function poses an important challenge. We attempted to divide the contributions to Volumes 3 and 4 according to these two types of experimental aims. As always, however, when one makes dichotomies, one finds them inadequate in treating certain data and our attempt is no exception. There are contributions that do not fit the classification and there are others which fit both. In addition, there are manuscripts which we wanted to include but which the authors were not ready to submit at this time. Larry Squire, Mortimer Mishkin, and others are making important contributions which donot appear in these volumes except among references throughout. But this was also the case for Volumes 1 and 2 where we sorely miss the irreplaceable contributions of James Olds, Ross Adey, and Brenda Milner. Volume 4 is concerned primarily with the role of the hippocampus in the ecology of the brain in regulating behavior and experience. The contri butions have the potential to raise the level of our understanding considerably.