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Author : Shrey Gandhi,Vinod Scaria
Publisher : Research in Genomics
Page : 128 pages
File Size : 49,7 Mb
Release : 2016-11-15
Category : Science
ISBN : 8210379456XXX
A handbook on computational analysis of whole exome sequence data
Author : Karoly Nikolich,Steven E. Hyman
Publisher : MIT Press
Page : 319 pages
File Size : 50,9 Mb
Release : 2015-08-21
Category : Medical
ISBN : 9780262029865
Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig
Author : Rolf Daniel,Meinhard Simon,Bernd Wemheuer
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 46,6 Mb
Release : 2018-08-03
Category : Electronic
ISBN : 9782889455386
Marine bacteria and archaea are key players in the biogeochemical cycling of nitrogen, carbon, and other elements. One important lineage of marine bacteria is the Roseobacter group. Members of this clade are the most abundant bacteria in marine ecosystems constituting up to 25% of the marine bacterioplankton. They have been detected in various marine habitats from coastal regions to deep-sea sediments and from polar regions to tropical latitudes. These bacteria are physiologically and genetically very versatile. Utilization of several organic and inorganic compounds, sulfur oxidation, aerobic anoxygenic photosynthesis, carbon monoxide oxidation, DMSP demethylation, and production of secondary metabolites are some of the important functional traits found in this clade. Moreover, several isolates are available allowing in-depth analysis of physiological and genetic characteristics. Although the Roseobacter group has been intensively studied in recent years, our understanding of its ecological contributions and the evolutionary processes shaping the genomes of this clade is still rather limited.
Author : Dean R. Jerry
Publisher : CRC Press
Page : 329 pages
File Size : 48,9 Mb
Release : 2013-10-26
Category : Science
ISBN : 9781482208078
This book covers the biology, ecology, genetics and aquaculture of the Asian Seabass or barramundi (Lates calcarifer), a commercially and recreationally valuable species. It brings together in the one place reviews written by world experts in Asian seabass taxonomy, genetics, nutrition, ecology, aquaculture, reproductive and developmental biology, climate change impacts, harvest quality and health management.
Author : Maria Anisimova
Publisher : Unknown
Page : 128 pages
File Size : 42,5 Mb
Release : 2012
Category : Evolutionary genetics
ISBN : 1617795828
Author : Marina Colombi ,Marco Ritelli
Publisher : MDPI
Page : 218 pages
File Size : 48,7 Mb
Release : 2020-12-14
Category : Science
ISBN : 9783039363223
Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders (HCTDs) characterized by a variable degree of skin hyperextensibility, joint hypermobility and tissue fragility. The current EDS classification distinguishes 13 subtypes and 19 different causal genes mainly involved in collagen and extracellular matrix synthesis and maintenance. EDS need to be differentiated from other HCTDs with a variable clinical overlap, including Marfan syndrome and related disorders, some types of skeletal dysplasia and cutis laxa. The clinical recognition of EDS is not always straightforward, and, for a definite diagnosis, molecular testing can be of great assistance, especially in patients with an uncertain phenotype. Currently, the major challenging task in EDS is to unravel the molecular basis of the hypermobile EDS that is the most frequent form, and for which the diagnosis is only clinical in the absence of any definite laboratory test. This EDS subtype, as well as other EDS-reminiscent phenotypes, are currently investigated worldwide to unravel the primary genetic defect and related pathomechanisms. The research articles, case report, and reviews published in the Special Issue entitled “Molecular Genetics and Pathogenesis of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders” focus on different clinical, genetic and molecular aspects of several EDS subtypes and some related disorders, offering novel findings and future research and nosological perspectives.
Author : Tom Strachan,Judith Goodship,Patrick Chinnery
Publisher : Taylor & Francis
Page : 545 pages
File Size : 50,9 Mb
Release : 2014-06-02
Category : Medical
ISBN : 9781317594307
Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti
Author : Célia Baroux,Marian Bemer
Publisher : Unknown
Page : 659 pages
File Size : 50,7 Mb
Release : 2018
Category : Botany
ISBN : 1493973185
Author : Marjorie F. Oleksiak,Om P. Rajora
Publisher : Springer Nature
Page : 458 pages
File Size : 45,9 Mb
Release : 2019-12-31
Category : Science
ISBN : 9783030379360
Population genomics has provided unprecedented opportunities to unravel the mysteries of marine organisms in the oceans' depths. The world's oceans, which make up 70% of our planet, encompass diverse habitats and host numerous unexplored populations and species. Population genomics studies of marine organisms are rapidly emerging and have the potential to transform our understanding of marine populations, species, and ecosystems, providing insights into how these organisms are evolving and how they respond to different stimuli and environments. This knowledge is critical for understanding the fundamental aspects of marine life, how marine organisms will respond to environmental changes, and how we can better protect and preserve marine biodiversity and resources. This book brings together leading experts in the field to address critical aspects of fundamental and applied research in marine species and share their research and insights crucial for understanding marine ecosystem diversity and function. It also discusses the challenges, opportunities and future perspectives of marine population genomics.
Author : EAAP scientific committee
Publisher : BRILL
Page : 485 pages
File Size : 53,5 Mb
Release : 2023-09-04
Category : Technology & Engineering
ISBN : 9789086867998
This Book of Abstracts is the main publication of the 65th Annual Meeting of the European Federation for Animal Science 2014 in Copenhagen, Denmark. It contains abstracts of the invited papers and contributed presentations. The meeting addressed subjects relating to science and innovation. Important problems were also discussed during the sessions of EAAP's nine Commissions: Animal Genetics, Animal Nutrition, Animal Management and Health, Animal Physiology, Cattle Production, Sheep and Goat Production, Pig Production, Horse Production and Livestock Farming Systems.
Author : Harry Chaudhary.
Publisher : STCD COMPANY
Page : 500 pages
File Size : 42,6 Mb
Release : 2018-09-15
Category : Computers
ISBN : 9780359095797
Array and Array Operations 6 Stack Operations 9 Queue Operations 16 Singly Linked List Operations 18 Singly Linked List 26 Doubly Linked List 35 Circular Linked List 42 Stack using Array 48 Stack using Linked List 52 Queue using Array 58 Queue using Linked List 64 Priority Queue 67 Double Ended Queue (Dequeue) 72 Stack using Queues 78 Decimal to Binary using Stacks 85 Towers of Hanoi 92 Bit Array 97 Dynamic Array 99 Parallel Array 101 Sparse Array 104 Matrix 112 Skip List 116 Xor Linked List 119 Xor Linked List-II 122 Binary Trees using Array 125 Binary Trees using Linked Lists 129 Preorder Traversal 132 Inorder Traversal 138 Binary Tree Properties 142 Binary Search Tree 145 AVL Tree 151 Cartesian Tree 155 Weight Balanced Tree 158 Red Black Tree 162 Splay Tree 166 Splay Tree 169 Heap 171 Binary Heap 173 Weak Heap 176 Binomial and Fibonacci Heap 178 Hash Tables 182 Direct Addressing Tables 185 Graph 187 Adjacency Matrix 191 Incidence Matrix and Graph Structured Stack 195 Adjacency List 198 Undirected Graph 201 Directed Graph 204 Directed Acyclic Graph 208 Propositional and Directed Acyclic Word Graph 212 Multigraph and Hypergraph 215 Binary Decision Diagrams & And Inverter Graph 218 Linear Search Iterative 221 Binary Search Iterative 229 Uniform Binary Search 233 Fibonacci Search 235 Selection Sort 237 Bubble Sort 240 Merge Sort 243 Pancake Sort 246 Depth First Search 250 Breadth First Search 253 Recursion 256 Factorial using Recursion 262 Fibonacci using Recursion 267 Sum of n Natural Numbers using Recursion 273 String Reversal using Recursion 279 Decimal to Binary Conversion using Recursion 285 Length of a Linked List using Recursion 292 Length of a String using Recursion 297 Largest and Smallest Number in an Array using Recursion 302 Largest and Smallest Number in a Linked List using Recursion 307 Search an Element in an Array using Recursion 313 Search an Element in a Linked List using Recursion 323 Dynamic Programming 331 Fibonacci using Dynamic Programming 334 Coin Change Problem 341 Maximum Sum of Continuous Subarray 346 Kadane’s Algorithm 352 Longest Increasing Subsequence 357 Rod Cutting 362 Minimum Number of Jumps 369 0/1 Knapsack Problem 375 Matrix-chain Multiplication 379 Longest Common Subsequence 387 Longest Palindromic Subsequence 393 Edit Distance Problem 400 Wagner-Fischer Algorithm 407 Catalan Number using Dynamic Programming 413 Assembly Line Scheduling 418 Minimum Insertions to form a Palindrome 425 Maximum Sum Rectangle in a 2D Matrix 432 Balanced Partition 437 Dice Throw Problem 444 Counting Boolean Parenthesizations 452 Topological Sort 455 TEST YOURSELF 458
Author : Ilga M. Porth,Amanda R. De la Torre
Publisher : Springer
Page : 218 pages
File Size : 48,8 Mb
Release : 2021-08-16
Category : Science
ISBN : 3030210030
This book offers comprehensive information on the genomics of spruces (Picea spp.), naturally abundant conifer tree species that are widely distributed in the Northern Hemisphere. Due to their tremendous ecological and economic importance, the management of forest genetic resources has chiefly focused on conservation and tree improvement. A draft genome sequence of the 20-gigabase Norway spruce genome was published in the journal Nature in 2013. Continuous efforts to improve the spruce genome assembly are underway, but are hindered by the inherent characteristics of conifer genomes: high amounts of repetitive sequences (introns and transposable elements) in the genome and large gene family expansions with regards to abiotic stress, secondary metabolism and spruces' defense responses to pathogens and herbivory. This book presents the latest information on the status of genome assemblies, provides detailed insights into transposable elements and methylation patterns, and highlights the extensive genomic resources available for inferring population genomics and climate adaptation, as well as emerging genomics tools for tree improvement programs. In addition, this volume features whole-genome comparisons among conifer species, and demonstrates how functional genomics can be used to improve gene function annotations. The book closes with an outlook on emerging fields of research in spruce genomics.
Author : Helga V. Toriello,Shelley D. Smith
Publisher : Oxford University Press
Page : 576 pages
File Size : 52,6 Mb
Release : 2013-06-20
Category : Medical
ISBN : 9780199313884
This is the third edition of the foremost medical reference on hereditary hearing loss. Chapters on epidemiology, embryology, non-syndromic hearing loss, and syndromic forms of hearing loss have all been updated with particular attention to the vast amount of new information on molecular mechanisms, and chapters on clinical and molecular diagnosis and on genetic susceptibility to ototoxic factors have been added. As in previous editions, the syndromes are grouped by system (visual, metabolic, cardiologic, neurologic, musculoskeletal, endocrine, etc.), with each chapter written by a recognized expert in the field. Written for practicing clinicians, this volume is an excellent reference for physicians, audiologists, and other professionals working with individuals with hearing loss and their families, and can also serve as a text for clinical training programs and for researchers in the hearing sciences.
Author : Rita Fior,Rita Zilhão
Publisher : Springer
Page : 216 pages
File Size : 43,6 Mb
Release : 2019-06-27
Category : Medical
ISBN : 9783030118129
This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
Author : Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
Publisher : Oxford University Press
Page : 976 pages
File Size : 55,5 Mb
Release : 2018-10-25
Category : Medical
ISBN : 9780190626662
The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.
