The Inflammatory Process

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 50,6 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

Get Book

Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : Benjamin W. Zweifach,Lester Grant,Robert T. McCluskey
Publisher : Academic Press
Page : 948 pages
File Size : 54,7 Mb
Release : 2014-05-12
Category : Nature
ISBN : 9781483261706

Get Book

The Inflammatory Process by Benjamin W. Zweifach,Lester Grant,Robert T. McCluskey Pdf

The Inflammatory Process focuses on the approaches, methodologies, and technologies involved in the study of the inflammatory process, including capillary structure, tissue injury, and inflammatory response. The selection first offers information on the experimental approach to inflammation, ultrastructural and biochemical consequences of cell injury, and ultrastructural basis of capillary permeability. Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation. The text then elaborates on the microvascular aspects of tissue injury and the sticking and emigration of white blood cells in inflammation. The book examines neutrophil and eosinophil leucocytes, "life history" and functions of lymphocytes, and metabolism and physiology of mononuclear phagocytes. Topics include inflammatory response, biochemistry and metabolism, special relationships to bacteria and viruses, and origins and early development of lymphocytes. The text also ponders on the role of lysosomes in tissue injury, hemostatic mechanisms in tissue injury, and anti-inflammatory agents. The selection is a vital source of data for researchers interested in the inflammatory process.

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 45,5 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

Get Book

Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Author : Adriano Rossi,Deborah A. Sawatzky
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 55,7 Mb
Release : 2008-03-17
Category : Medical
ISBN : 9783764375065

Get Book

The Resolution of Inflammation by Adriano Rossi,Deborah A. Sawatzky Pdf

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 41,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

Get Book

Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 46,5 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

Get Book

Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 49,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Z. Kmiec
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 41,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642565533

Get Book

Cooperation of Liver Cells in Health and Disease by Z. Kmiec Pdf

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 40,5 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

Get Book

Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : A. L. Notkins,M. B. A. Oldstone
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461252504

Get Book

Concepts in Viral Pathogenesis by A. L. Notkins,M. B. A. Oldstone Pdf

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 49,6 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780128214565

Get Book

Immunomodulatory Biomaterials by Stephen F. Badylak,Jennifer Elisseeff Pdf

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Biologic Markers
Publisher : National Academies Press
Page : 198 pages
File Size : 49,5 Mb
Release : 1989-02-01
Category : Science
ISBN : 0309039924

Get Book

Biologic Markers in Pulmonary Toxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Biologic Markers Pdf

Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.

Author : Waliza Ansar,Shyamasree Ghosh
Publisher : Springer
Page : 301 pages
File Size : 46,5 Mb
Release : 2016-03-23
Category : Medical
ISBN : 9788132226802

Get Book

Biology of C Reactive Protein in Health and Disease by Waliza Ansar,Shyamasree Ghosh Pdf

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Author : Maurício Rocha e Silva,João Garcia-Leme,Hanna A. Rothschild
Publisher : Pergamon
Page : 284 pages
File Size : 42,8 Mb
Release : 1972
Category : Medical
ISBN : UOM:39015003235655

Get Book

Chemical Mediators of the Acute Inflammatory Reaction by Maurício Rocha e Silva,João Garcia-Leme,Hanna A. Rothschild Pdf

Chemical Mediators of the Acute Inflammatory Reaction ...

Author : Artemis Morris,Molly Rossiter
Publisher : John Wiley & Sons
Page : 384 pages
File Size : 55,9 Mb
Release : 2011-08-10
Category : Health & Fitness
ISBN : 9781118145425

Get Book

Anti-Inflammation Diet For Dummies by Artemis Morris,Molly Rossiter Pdf

Trusted information and healthy, delicious recipes to fight inflammation Low-grade inflammation is a condition inside the body, directly related to diet, that slowly wears on the body, facilitating chronic diseases like arthritis, diabetes, obesity, and heart disease. Also, the latest research has detected a correlation between inflammation and conditions like severe allergies, asthma, and even cancer. Anti-Inflammation Diet For Dummies takes a preventative dietary approach to fighting inflammation by stimulating natural healing with anti-inflammatory foods and supplements. It reveals the causes of inflammation and provides a how-to prescription for eliminating it through diet changes, stress reduction, and healthy weight loss. Defines what inflammation is, how it develops, and its associated risks Outlines foods and supplements rich in natural inflammation-fighting agents 100 healthy and delicious recipes loaded with anti-inflammatory agents Anti-Inflammation For Dummies is an invaluable resource to help you make smart diet choices by avoiding problematic foods that instigate the inflammatory process, and arms you with knowledge and delicious recipes to get on the road to a healthier you.