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Author : Douglas Shepard Riggs
Publisher : Unknown
Page : 472 pages
File Size : 46,7 Mb
Release : 1968
Category : Biomathematics
ISBN : CORNELL:31924003617846
Author : Douglas Shepard Riggs
Publisher : Unknown
Page : 445 pages
File Size : 53,9 Mb
Release : 1970
Category : Electronic
ISBN : OCLC:251912629
Author : P. van den Driessche
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 54,6 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783642454554
A conference on "Some Mathematical Problems in Biology" was held at the University of Victoria, Victoria, B. C. , Canada, from May 7 - 10, 1973. The participants and invited speakers were mathematicians interested in problems of a biological nature, and scientists actively engaged in developing mathematical models in biological fields. One aim of the conference was to attempt to assess what the recent rapid growth of mathematical interaction with the biosciences has accomplished and may accomplish in the near future. The conference also aimed to expose the problems of communication bet~",een mathematicians and biological scientists, and in doing so to stimulate the interchange of ideas. It was recognised that the topic spans an enormous breadth, and little attempt was made to balance the very diverse areas. Widespread active interest was shown in the conference, and just over one hundred people registered. The varied departments and institutions across North America from which the participants came made it both academically and geographically mixed. The chief activity of the conference was the presentation of papers. Nine invited guest speakers (see table of contents) each gave a one hour talk. These covered a wide range of topics. There were twenty-five shorter (twenty minute) contributed papers, and almost all papers l,rere followed by a five minute question and discussion period. Duplicated abstracts of presented papers were available at the meeting. An evening informal discussion meeting of participants, chaired by Dr. A. B. Tayler, and led by Drs. E. M. Hagmeier, E. C.
Author : Carlos Castillo-Chavez,Simon A. Levin,Christine A. Shoemaker
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 54,7 Mb
Release : 2013-03-08
Category : Mathematics
ISBN : 9783642466939
Increasingly, mathematical methods are being used to advantage in addressing the problems facing humanity in managing its environment. Problems in resource management and epidemiology especially have demonstrated the utility of quantitative modeling. To explore these approaches, the Center of Applied Mathematics at Cornell University organized a conference in Fall, 1987, with the objective of surveying and assessing the state of the art. This volume records the proceedings of that conference. Underlying virtually all of these studies are models of population growth, from individual cells to large vertebrates. Cell population growth presents the simplest of systems for study, and is of fundamental importance in its own right for a variety of medical and environmental applications. In Part I of this volume, Michael Shuler describes computer models of individual cells and cell populations, and Frank Hoppensteadt discusses the synchronization of bacterial culture growth. Together, these provide a valuable introduction to mathematical cell biology.
Author : James Keener,James Sneyd
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 41,7 Mb
Release : 2010-06-04
Category : Mathematics
ISBN : 9780387758473
Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing. New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included. Reviews from first edition: Keener and Sneyd's Mathematical Physiology is the first comprehensive text of its kind that deals exclusively with the interplay between mathematics and physiology. Writing a book like this is an audacious act! -Society of Mathematical Biology Keener and Sneyd's is unique in that it attempts to present one of the most important subfields of biology and medicine, physiology, in terms of mathematical "language", rather than organizing materials around mathematical methodology. -SIAM review
Author : Murray S. Klamkin
Publisher : SIAM
Page : 346 pages
File Size : 50,8 Mb
Release : 1987-01-01
Category : Technology & Engineering
ISBN : 9780898712049
Mathematics of Computing -- Miscellaneous.
Author : Edward A. Bender
Publisher : Courier Corporation
Page : 274 pages
File Size : 43,8 Mb
Release : 2012-05-23
Category : Mathematics
ISBN : 9780486137124
Employing a practical, "learn by doing" approach, this first-rate text fosters the development of the skills beyond the pure mathematics needed to set up and manipulate mathematical models. The author draws on a diversity of fields — including science, engineering, and operations research — to provide over 100 reality-based examples. Students learn from the examples by applying mathematical methods to formulate, analyze, and criticize models. Extensive documentation, consisting of over 150 references, supplements the models, encouraging further research on models of particular interest. The lively and accessible text requires only minimal scientific background. Designed for senior college or beginning graduate-level students, it assumes only elementary calculus and basic probability theory for the first part, and ordinary differential equations and continuous probability for the second section. All problems require students to study and create models, encouraging their active participation rather than a mechanical approach. Beyond the classroom, this volume will prove interesting and rewarding to anyone concerned with the development of mathematical models or the application of modeling to problem solving in a wide array of applications.
Author : Rodrick Wallace,Deborah Wallace
Publisher : World Scientific
Page : 238 pages
File Size : 52,8 Mb
Release : 2013
Category : Business & Economics
ISBN : 9781848169975
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule OC magic bulletOCO interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States OCo from $200 million in 1950 to $1.2 billion in 2010 OCo has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of OC magic bulletsOCO, we must now apply OC magic strategiesOCO that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies."
Author : Rodrick Wallace,Deborah Wallace
Publisher : World Scientific
Page : 240 pages
File Size : 47,5 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781848169982
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing. The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness. In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies. Contents:Beyond Magic BulletsExpanding the TheoryDynamic ‘Regression Models’An Evolutionary ExcursionExample: Mental DisordersExample: Protein FoldingExample: Glycome DeterminantsExample: Glycan/Lectin Logic GatesExample: IDP Logic GatesTreatmentHistory and HealthBeyond GlasperlenspielMathematical Appendix Readership: Undergraduate, graduate, researchers and professionals in biomathematics, biostatistics, mathematical modeling, complex systems and pharmaceuticals. Keywords:Cognition;Information Theory;Mathematical Model;Social EpidemiologyKey Features:The book synthesizes published, peer-reviewed articles to make explicit the complexity of human biology that underlies the catastrophic failure of the pharmaceutical industryIt develops a formalism of statistical tools for modeling and data analysis to explicitly address that multiscale and multilevel complexityIt uses the formalism to explore case histories at a number of scales
Author : D E Hathway
Publisher : Royal Society of Chemistry
Page : 476 pages
File Size : 46,8 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847556042
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Author : L. Ridgway Scott,Ariel Fernández
Publisher : Springer
Page : 290 pages
File Size : 51,9 Mb
Release : 2017-12-04
Category : Mathematics
ISBN : 9783319660325
This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about the biophysics of proteins. L. Ridgway Scott has been Professor of Computer Science and of Mathematics at the University of Chicago since 1998, and the Louis Block Professor since 2001. He obtained a B.S. degree (Magna Cum Laude) from Tulane University in 1969 and a PhD degree in Mathematics from the Massachusetts Institute of Technology in 1973. Professor Scott has published over 130 papers and three books, extending over biophysics, parallel computing and fundamental computing aspects of structural mechanics, fluid dynamics, nuclear engineering, and computational chemistry. Ariel Fernández (born Ariel Fernández Stigliano) is an Argentinian-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University and held the Karl F. Hasselmann Endowed Chair Professorship in Bioengineering at Rice University. He is currently involved in research and entrepreneurial activities at various consultancy firms. Ariel Fernández authored three books on translational medicine and biophysics, and published 360 papers in professional journals. He holds two patents in the field of biotechnology.
Author : Dennis J. Paustenbach
Publisher : John Wiley & Sons
Page : 1319 pages
File Size : 54,5 Mb
Release : 2024-04-15
Category : Technology & Engineering
ISBN : 9781119742968
Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.
Author : Philip Russell Wallace
Publisher : Courier Corporation
Page : 644 pages
File Size : 53,9 Mb
Release : 1984-01-01
Category : Science
ISBN : 9780486646763
This mathematical reference for theoretical physics employs common techniques and concepts to link classical and modern physics. It provides the necessary mathematics to solve most of the problems. Topics include the vibrating string, linear vector spaces, the potential equation, problems of diffusion and attenuation, probability and stochastic processes, and much more. 1972 edition.
Author : Claudio Cobelli,David Foster,Gianna Toffolo
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 41,9 Mb
Release : 2000
Category : Mathematics
ISBN : 9780306464270
The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modeling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies and/or to develop multicompartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the noncompartmental and multicompartmental modeling methodologies to study systems in the steady state. The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how `good' a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has an extensive section on parameter estimation, i.e., fitting models to data, first in general terms and then specifically related to noncompartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the `black box' of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.
Author : Jimmy D. Bartlett
Publisher : Elsevier
Page : 944 pages
File Size : 46,6 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483193915
Clinical Ocular Pharmacology, Second Edition covers the diagnostic and therapeutic clinical procedures in the administration of drugs to the eye. This book is organized into five parts encompassing 35 chapters that evaluate the basic pharmacologic principles that govern the different types of ophthalmic drugs. It addresses the pharmacologic agents useful in the diagnosis and treatment of ocular diseases. Some of the topics covered in the book are the basic science of ocular pharmacology; clinical administration of ocular drugs; drugs affecting the autonomic nervous system; types of local anesthetics; review of anti-inflammatory drugs; and examination of inhibitors of aqueous formation. Other parts deal with the development of contact lens solution in clinical practice and the pharmacologic management of strabismus. These topics are followed by discussions of the legal basis of using drugs in optometry and the systemic effects of ocular drugs. The concluding part is devoted to the diseases of the optic nerve. The book can provide useful information to doctors, optometrists, pediatricians, students, and researchers.