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Author : L. Bosch
Publisher : Unknown
Page : 614 pages
File Size : 50,8 Mb
Release : 1972
Category : Proteins
ISBN : UCAL:B4298397
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Greco Hernández,Rosemary Jagus
Publisher : Springer
Page : 564 pages
File Size : 54,8 Mb
Release : 2016-08-10
Category : Science
ISBN : 9783319394688
The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.
Author : John W. B. Hershey,Nahum Sonenberg,Michael Mathews
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 54,7 Mb
Release : 2012
Category : Science
ISBN : 1936113465
The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.
Author : Anthony Gordan San Pietro,Marvin R. Lamborg,Francis T. Kenney
Publisher : Unknown
Page : 504 pages
File Size : 50,9 Mb
Release : 1968
Category : Science
ISBN : WISC:89031247588
Author : Knud H. Nierhaus,Daniel Wilson
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 47,8 Mb
Release : 2009-07-10
Category : Science
ISBN : 9783527616381
Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 52,9 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author : Francis T. Kenney,Anthony Gordan San Pietro
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 1968
Category : Cellular control mechanisms
ISBN : OCLC:397205402
Author : Engin Bermek
Publisher : Springer
Page : 240 pages
File Size : 54,9 Mb
Release : 1985
Category : Science
ISBN : WISC:89011366127
Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 350 pages
File Size : 48,9 Mb
Release : 2008-10-29
Category : Science
ISBN : 142004415X
The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.
Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 448 pages
File Size : 52,6 Mb
Release : 1999-09-15
Category : Technology & Engineering
ISBN : 9780309172813
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Author : P.J. Buttery,D.B. Lindsay
Publisher : Butterworth-Heinemann
Page : 314 pages
File Size : 55,8 Mb
Release : 2013-10-22
Category : Technology & Engineering
ISBN : 9781483161815
Protein Deposition in Animals explores the factors controlling protein deposition in farm animals including fish, poultry, and ruminants. Topics covered range from protein biosynthesis in eukaryotic cells and protein metabolism in intact animals to whole-body amino acid metabolism, synthesis of egg proteins, and metabolism of the fetus. The energy costs of protein metabolism, dietary constraints on nitrogen retention, and metabolism in muscle are also discussed. Emphasis is placed on the factors that influence protein production by animals. This book is comprised of 15 chapters; the first of which explains some fundamental aspects of protein synthesis, followed by a topic of the molecular control of protein breakdown. Two chapters then consider the measurement of whole-body protein metabolism and the integration of the metabolism of individual organs with the rest of the animal. Two 'tissues', the muscle and the fetus, are singled out for detailed analysis in subsequent chapters, while another chapter describes the synthesis of egg proteins. The factors that influence overall nitrogen retention by the animals are also examined, along with the energy costs of protein deposition, hormonal influences on protein deposition, and the use of anabolic agents to manipulate growth. Two chapters, one on poultry and the other on ruminants, are concerned with predicting rates of protein deposition. This text concludes by discussing the protein metabolism in fish. This book will be of interest to scientists working in the fields of applied biochemistry, animal nutrition and physiology, physiology, and agriculture.
Author : Robert F. Goldberger,Keith R. Yamamoto
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 47,5 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781475746198
The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.
Author : Jacques Lapointe,Lea Brakier-Gigras
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 41,6 Mb
Release : 2003-07-31
Category : Science
ISBN : 0306478390
Translation Mechanisms provides investigators and graduate students with overviews of recent developments in the field of protein biosynthesis that are fuelled by the explosive and synergic growth of structural biology, genomics, and bioinformatics. The outstanding progress in our understanding of the structure, dynamics, and evolution of the prokaryotic and eukaryotic translation machinery, as well as applications in medicine and biotechnology, are described in 26 chapters covering recent discoveries on: -the subtleties of tRNA aminoacylation with natural and unnatural amino acids. -the control of mRNA stability, a key step of gene regulation. -ribosome structure and function, in the era of the atomic-crystal resolution of the ribosome. -the regulation of the biosynthesis of the translational machinery components. -the action of a variety of inhibitors of translation and the prospect for clinical studies.
Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
Page : 66 pages
File Size : 44,5 Mb
Release : 2011
Category : Medical
ISBN : 9781615041381
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
