The Natural Killer Cell

Author : Michael T. Lotze,Angus W. Thomson
Publisher : Academic Press
Page : 660 pages
File Size : 40,7 Mb
Release : 2009-11-12
Category : Medical
ISBN : 0080919294

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Natural Killer Cells by Michael T. Lotze,Angus W. Thomson Pdf

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Author : Eric Vivier,James Di Santo,Alessandro Moretta
Publisher : Springer
Page : 247 pages
File Size : 48,7 Mb
Release : 2016-02-15
Category : Medical
ISBN : 9783319239163

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Natural Killer Cells by Eric Vivier,James Di Santo,Alessandro Moretta Pdf

To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

Author : Jacques Zimmer
Publisher : Springer Science & Business Media
Page : 428 pages
File Size : 55,6 Mb
Release : 2010-01-12
Category : Medical
ISBN : 9783642023095

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Natural Killer Cells by Jacques Zimmer Pdf

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.

Author : Kerry S. Campbell,Marco Colonna
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 51,6 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592590445

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Natural Killer Cell Protocols by Kerry S. Campbell,Marco Colonna Pdf

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial migration, in vivo detection of cells migrating into tumors, immunofluorescence staining of intracellular cytokines, and in vitro NK cell development. Valuable techniques for specific applications include vaccinia virus protein expression, soluble KIR-Fc fusions for HLA class I binding assays, calcium mobilization in cell conjugates, and identification of heterodimeric receptor complexes using cDNA library expression cloning. No less important are accounts of such classic methods as hybrid resistance, ADCC, viral defense, target cell cytotoxicity assays, cloning and culturing, tumor immunotherapy, and generation of HLA class I transfected target cells. Natural Killer Cell Protocols: Cellular and Molecular Methods offers immunologists, cancer researchers, virologists, and cell biologists today's most comprehensive collection of both established and cutting-edge techniques, methods that will contribute significantly to advancing our understanding of this fascinating and critically important class of cells.

Author : Srinivas S. Somanchi
Publisher : Humana Press
Page : 365 pages
File Size : 40,8 Mb
Release : 2016-05-13
Category : Medical
ISBN : 1493936824

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Natural Killer Cells by Srinivas S. Somanchi Pdf

This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.

Author : Harriet Alida Lye
Publisher : McClelland & Stewart
Page : 304 pages
File Size : 49,8 Mb
Release : 2020-12-29
Category : Biography & Autobiography
ISBN : 9780771049248

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Natural Killer by Harriet Alida Lye Pdf

"I need people to know that I exist, that their experiment worked, that by some combination of luck and science, I'm alive." In this harrowing and intimate memoir, Harriet Alida Lye explores how, at just fifteen years old, she was diagnosed with a form of leukemia called Natural Killer, named "the rarest and worst malignancy." The average survival time of patients with this diagnosis is fifty-eight days. There are no known survivors. There were no known survivors. Fifteen years after Harriet's diagnosis, she became pregnant, despite having been told that her chemotherapy treatment would likely make conception impossible. To be a mother is to make a death, as death is bound up in life. She knew her body had the ability to create death. She never trusted, was told to not even imagine, that it also had the power, that magical banality, to create life. Weaving in source material from the year she spent in hospital, written by both of her parents and her teenage self, this personal reflection is told through a seamless blend of narrative, snapshots, journal entries, and blog updates posted for friends and family. With probing lyricism and searing honesty, Natural Killer explores what it's like to live with a life-threatening illness and survive it; what it means for a body to turn against itself, to self-destruct from within; and what it takes to regain trust in a body that has committed the ultimate betrayal.

Author : Claire E. Lewis,James O'Donnell McGee
Publisher : Oxford University Press, USA
Page : 276 pages
File Size : 55,8 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015020845528

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The Natural Killer Cell by Claire E. Lewis,James O'Donnell McGee Pdf

The ability of an organism to combat infection by foreign particles and microbial pathogens is essential for its survival and evolutionary success. Such efforts at immunity can take two forms. A considerable number of works have been published which focus on the central role of antigen recognition and antibody structure and function in the host response to infection. This volume, however, discusses the recent shift in focus towards the "natural" or "innate" immune system which consists of various cell types and factors. These cells and factors can take part in immune responses without prior sensitization, and have important modulatory effects on later, specific responses. This work reviews the biology and function of the natural killer cell, covering such topics as the molecular basis of natural killer cell function and its role in viral infection, tumor biology, and transplantation. Graduate students and researchers in immunology, cell biology, and medicine will find this work a valuable resource on current research in this exciting field.

Author : Ronald Herberman
Publisher : Elsevier
Page : 694 pages
File Size : 45,9 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323143356

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Mechanisms of Cytotoxicity by NK Cells by Ronald Herberman Pdf

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity. The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed. This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others.

Author : Olli Vainio,Beat A. Imhof
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642800573

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Immunology and Developmental Biology of the Chicken by Olli Vainio,Beat A. Imhof Pdf

Books on both chicken immunology and developmental biology are rare. This one, however, summarizes all aspects of both areas and therefore represents a valuable compendium for experienced researchers as well as for all newcomers to the field. Following a lengthy discussion of the origin of hemopoietic cells, regulatory elements for the differentiation of these cells and B and T cell lymphopoiesis, the book goes on to describe the generation of transgenic chickens as well as an additional basic feature in embryogenesis: the positioning of organ anlage, e.g. the limb bud. To round off, a valuable compilation of monoclonal antibodies further enhances the practical usefulness of this important book.

Author : Massimo Vitale,Simona Sivori,Michael A. Caligiuri
Publisher : Frontiers Media SA
Page : 256 pages
File Size : 54,6 Mb
Release : 2020-03-24
Category : Electronic
ISBN : 9782889636129

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Natural Killer Cells in Tissue Compartments by Massimo Vitale,Simona Sivori,Michael A. Caligiuri Pdf

Author : Eva Lotzova,Ronald B. Herberman
Publisher : CRC Press
Page : 374 pages
File Size : 55,7 Mb
Release : 2019-07-23
Category : Health & Fitness
ISBN : 9781000697216

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Immunobiology Of Natural Killer Cells by Eva Lotzova,Ronald B. Herberman Pdf

First published in 1986: This book contributes to the advancing knowledge of reads in the field of NK cells, and will be helpful as a teaching device.

Author : Srinivas S. Somanchi
Publisher : Methods in Molecular Biology
Page : 384 pages
File Size : 49,5 Mb
Release : 2018-05-27
Category : Medical
ISBN : 1493981161

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Natural Killer Cells: Methods and Protocols by Srinivas S. Somanchi Pdf

Author : Eric Vivier,Marco Colonna
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 42,6 Mb
Release : 2005-12-20
Category : Medical
ISBN : 9783540277439

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Immunobiology of Natural Killer Cell Receptors by Eric Vivier,Marco Colonna Pdf

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Author : Birgit Weinberger
Publisher : Karger Medical Scientific
Page : 0 pages
File Size : 44,8 Mb
Release : 2020
Category : Medical
ISBN : 331806677X

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Vaccines for Older Adults by Birgit Weinberger Pdf

Many infectious diseases are more frequent and are associated with high morbidity and mortality in older adults. Vaccination is the most efficient strategy to prevent infections, and older adults are an important target population for vaccination in order to promote health in this age group. Age-related changes in the immune system as well as other factors, such as comorbidities, obesity or frailty, influence vaccine-induced immune responses in old age. Awareness that vaccines developed for children might not be optimal for adults, and particularly for the older population, has only arisen in the recent past. Vaccination against influenza, pneumococcal disease, and herpes zoster is specifically recommended for older adults in many countries, and various strategies have been pursued in order to optimize these vaccines. However, there are still many pathogens, which severely affect the older population, but for which no vaccines are currently available. Extensive research and development are ongoing to further improve existing vaccines and to design novel vaccines in order to provide protection for this vulnerable age group. In order to exploit the full protective potential of vaccines it is essential to improve vaccine uptake and overcome vaccine hesitancy by providing information and education to stakeholders, health care professionals, and the general public. This book is relevant for researchers working on age-related changes in the immune system or on vaccine development, for health care professionals treating older patients, and for the stakeholders and decision makers involved in vaccination recommendations and implementation.

Author : Shoba Amarnath
Publisher : Humana
Page : 0 pages
File Size : 44,6 Mb
Release : 2020-03-09
Category : Medical
ISBN : 107160337X

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Innate Lymphoid Cells by Shoba Amarnath Pdf

This volume explores the latest techniques used to characterize murine and human Innate Lymphoid Cells (ILC) subsets. This book also aims to discuss useful phenotypical and functional assays that may be relevant for studying ILC function in mice and humans. Chapters cover topics such as methods to study microbiome and enteroid cultures; characterizing ILC precursors; and cellular engineering of ILCs for therapeutic use. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Innate Lymphoid Cells: Methods and Protocols is a valuable research tool for anyone interested in ILC biology, and those interested in fundamental immunology, cellular engineering, cell signaling, and clinician scientists.