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Author : Francesca Mapua Filbey
Publisher : Cambridge University Press
Page : 209 pages
File Size : 43,6 Mb
Release : 2019-03-14
Category : Medical
ISBN : 9781107127982
Combines classic theories with current neuroscientific studies to explain the addiction cycle, focusing on neuroimaging studies and applications.
Author : Judith Grisel
Publisher : Anchor
Page : 258 pages
File Size : 45,6 Mb
Release : 2020-01-14
Category : Psychology
ISBN : 9780525434900
A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.
Author : Cynthia M. Kuhn,George F. Koob
Publisher : CRC Press
Page : 238 pages
File Size : 53,8 Mb
Release : 2010-04-12
Category : Science
ISBN : 9780849373916
Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by an international team of authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention. The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enable researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior. The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.
Author : George F. Koob,Michel Le Moal
Publisher : Elsevier
Page : 503 pages
File Size : 50,6 Mb
Release : 2005-11-11
Category : Psychology
ISBN : 9780080497372
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Author : Stephen J. Wilson
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 55,6 Mb
Release : 2015-07-07
Category : Psychology
ISBN : 9781118472248
This volume provides a thorough and up-to-date synthesis of the expansive and highly influential literature from the last 30 years by bringing together contributions from leading authorities in the field, with emphasis placed on the most commonly investigated drugs of abuse. Emphasises the most commonly investigated drugs of abuse, including alcohol, cocaine, nicotine, and opiates Brings together the work of the leading authorities in all major areas of the field Provides novel coverage of cutting-edge methods for using cognitive neuroscience to advance the treatment of addiction, including real-time neurofeedback and brain stimulation methods Includes new material on emerging themes and future directions in the use of cognitive neuroscience to advance addiction science
Author : Adrian Carter,Wayne Hall
Publisher : Cambridge University Press
Page : 365 pages
File Size : 50,8 Mb
Release : 2011-11-17
Category : Medical
ISBN : 9781139504676
Addiction is a significant health and social problem and one of the largest preventable causes of disease globally. Neuroscience promises to revolutionise our ability to treat addiction, lead to recognition of addiction as a 'real' disorder in need of medical treatment and thereby reduce stigma and discrimination. However, neuroscience raises numerous social and ethical challenges: • If addicted individuals are suffering from a brain disease that drives them to drug use, should we mandate treatment? • Does addiction impair an individual's ability to consent to research or treatment? • How will neuroscience affect social policies towards drug use? Addiction Neuroethics addresses these challenges by examining ethical implications of emerging neurobiological treatments, including: novel psychopharmacology, neurosurgery, drug vaccines to prevent relapse, and genetic screening to identify individuals who are vulnerable to addiction. Essential reading for academics, clinicians, researchers and policy-makers in the fields of addiction, mental health and public policy.
Author : Carlton K. Erickson
Publisher : W. W. Norton & Company
Page : 303 pages
File Size : 40,8 Mb
Release : 2007-02-17
Category : Medical
ISBN : 9780393704631
Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.
Author : Marc Lewis
Publisher : Doubleday Canada
Page : 320 pages
File Size : 53,8 Mb
Release : 2015-08-04
Category : Self-Help
ISBN : 9780385682299
Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the “disease model” of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease, based on evidence that brains change with drug use. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it’s supposed to do—seek pleasure and relief—in a world that’s not cooperating. Brains are designed to restructure themselves with normal learning and development, but this process is accelerated in addiction when highly attractive rewards are pursued repeatedly. Lewis shows why treatment based on the disease model so often fails, and how treatment can be retooled to achieve lasting recovery, given the realities of brain plasticity. Combining intimate human stories with clearly rendered scientific explanation, The Biology of Desire is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.
Author : David W. Self,Julie K. Staley Gottschalk
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 49,6 Mb
Release : 2009-12-18
Category : Medical
ISBN : 9783642030017
Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.
Author : Dr. Anna Lembke
Publisher : Penguin
Page : 305 pages
File Size : 48,5 Mb
Release : 2021-08-24
Category : Psychology
ISBN : 9781524746735
INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.
Author : George F. Koob,Michael A. Arends,Michel Le Moal
Publisher : Academic Press
Page : 351 pages
File Size : 47,8 Mb
Release : 2014-07-12
Category : Medical
ISBN : 9780123869593
Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction
Author : Victor R. Preedy
Publisher : Academic Press
Page : 736 pages
File Size : 43,8 Mb
Release : 2019-03-19
Category : Medical
ISBN : 9780128131268
Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects
Author : Victor R. Preedy
Publisher : Academic Press
Page : 774 pages
File Size : 40,8 Mb
Release : 2017-05-23
Category : Psychology
ISBN : 9780128037928
The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms
Author : Office of the Surgeon General,U.s. Department of Health and Human Services
Publisher : Createspace Independent Publishing Platform
Page : 420 pages
File Size : 45,8 Mb
Release : 2017-08-15
Category : Electronic
ISBN : 1974580628
All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.
Author : Alan C. Swann,F. Gerard Moeller,Marijn Lijffijt
Publisher : Oxford University Press, USA
Page : 0 pages
File Size : 43,7 Mb
Release : 2016
Category : Medical
ISBN : 0199367892
Neurobiology of Addiction highlights some of the most promising research areas of the rapidly expanding field of addiction. It will be useful as a practical tool for clinicians, research investigators, and trainees-both in addiction and in other illnesses with overlapping mechanisms-as well as an informative resource for non-technical readers who are interested in addiction or mental health policy. The editors have combined their areas of expertise to provide a unique perspective into the prevention and treatment of addictive disorders. Their approach addresses addiction in the broader context of behavioral processes and survival-related adaptations, focusing on its neurobiological precursors and drawing parallels between addictions and other recurrent or progressive psychiatric disorders. The book also emphasizes resilience, clinical contexts of addictive behavior, and treatment strategies that target its underlying neurobiological mechanisms.