The Neurobiology Of Drug And Alcohol Addiction

Author : Carlton K. Erickson
Publisher : W. W. Norton & Company
Page : 312 pages
File Size : 43,5 Mb
Release : 2007-02-17
Category : Psychology
ISBN : 0393076229

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The Science of Addiction: From Neurobiology to Treatment by Carlton K. Erickson Pdf

Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.

Author : George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal
Publisher : Academic Press
Page : 402 pages
File Size : 47,9 Mb
Release : 2021-07-07
Category : Psychology
ISBN : 9780128167946

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Alcohol by George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal Pdf

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol

Author : George F. Koob,Michel Le Moal
Publisher : Elsevier
Page : 503 pages
File Size : 47,7 Mb
Release : 2005-11-11
Category : Psychology
ISBN : 9780080497372

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Neurobiology of Addiction by George F. Koob,Michel Le Moal Pdf

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Author : Anonim
Publisher : Unknown
Page : 76 pages
File Size : 49,6 Mb
Release : 2007
Category : Brain
ISBN : MINN:31951D025861296

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Drugs, Brains, and Behavior by Anonim Pdf

Author : Trevor W. Robbins,Barry J. Everitt,David J. Nutt
Publisher : Unknown
Page : 327 pages
File Size : 45,9 Mb
Release : 2010
Category : Medical
ISBN : 9780199562152

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The Neurobiology of Addiction by Trevor W. Robbins,Barry J. Everitt,David J. Nutt Pdf

In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology. The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.

Author : Peter W. Kalivas,Herman H. Samson
Publisher : Unknown
Page : 568 pages
File Size : 50,7 Mb
Release : 1992
Category : Alcohol
ISBN : STANFORD:36105000131271

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The Neurobiology of Drug and Alcohol Addiction by Peter W. Kalivas,Herman H. Samson Pdf

Papers of a conference on [title] held by the New York Academy of Sciences, July 1991, in Spokane, Washington. No index. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Marc Lewis
Publisher : Doubleday Canada
Page : 320 pages
File Size : 43,8 Mb
Release : 2015-08-04
Category : Self-Help
ISBN : 9780385682299

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The Biology of Desire by Marc Lewis Pdf

Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the “disease model” of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease, based on evidence that brains change with drug use. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it’s supposed to do—seek pleasure and relief—in a world that’s not cooperating. Brains are designed to restructure themselves with normal learning and development, but this process is accelerated in addiction when highly attractive rewards are pursued repeatedly. Lewis shows why treatment based on the disease model so often fails, and how treatment can be retooled to achieve lasting recovery, given the realities of brain plasticity. Combining intimate human stories with clearly rendered scientific explanation, The Biology of Desire is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.

Author : Ashok K. Singh
Publisher : Academic Press
Page : 366 pages
File Size : 54,5 Mb
Release : 2020-09-24
Category : Psychology
ISBN : 9780128198919

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Neurobiology of Alcohol and the Brain by Ashok K. Singh Pdf

According to the 2018 National Survey on Drug Use and Health, 14.4 million adults aged 18 and older had alcohol use disorder (AUD). Mixing alcohol with other drugs such as opioids or cocaine has become an emerging trend, exacerbating public health concerns and may synergistically augment the seriousness of the adverse effects such as withdrawal symptoms, cardiovascular disorders, liver damage, reproductive abnormalities, and behavioral abnormalities. Despite the seriousness of the situation, possible mechanisms underlying the addiction and the withdrawal symptoms is not yet understood. This has been one of the key hindrances in developing effective treatment. Neurobiology of Alcohol and the Brain addresses the addiction-related problems reviewing both the mechanisms and withdrawal system with alcohol addiction. First, the book discusses the mechanisms of the rewarding and aversive effects, including addiction and the withdrawal symptoms of alcohol drinking. Next, alcohol's interaction with other drugs and ensuing adverse consequences is discussed including current and novel treatments against alcoholism. This is followed by a closer look at mental health and alcohol use disorder comorbidity. Lastly, the reader is provided with examples of an experimental study that describes possible protective effects of gold nanoparticles against alcohol addiction in rats subjected to alcohol self-administration. Neurobiology of Alcohol and the Brain will unlock the mechanistic diversities of alcoholism helping to facilitate future developments of new, personalized treatment options for patients suffering from alcohol addiction. Provides an exhaustive overview of neurobiology of alcohol addiction, including significant recent advances Discusses the mechanisms underlying the adverse effects of alcohol-drug mixtures Includes recent experimental studies on gold nanoparticles

Author : Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research
Publisher : National Academies Press
Page : 236 pages
File Size : 41,6 Mb
Release : 1997-11-10
Category : Medical
ISBN : 9780309174596

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Dispelling the Myths About Addiction by Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research Pdf

Every year about half a million men, women, and children in the United States die from the effects of using nicotine, alcohol, and illegal drugs: one of every four American deaths. Yet research to solve this terrible problem is often perceived as less important than other types of biomedical investigation. Focusing on four major classes of drugs with the greatest social and economic impactâ€"nicotine, alcohol, opioids, and stimulantsâ€"Dispelling the Myths About Addiction examines what is known about addiction and what is needed to develop a talented cadre of investigators and to educate the public about addiction research. The committee explores these areas: Economic costs of addiction. What has been learned about addiction from research into basic neurobiology and the brain, psychosocial and behavioral factors, and epidemiology. Education and training of researchers and the research infrastructure. Public perceptions and their impact on public policy in this field. This volume outlines the challenges and opportunities in addiction research today and makes recommendations to educators, treatment professionals, public and private institutions, and others for how to build support for addiction research and treatment.

Author : George F. Koob,Michael A. Arends,Mandy L. McCracken,Michel Le Moal
Publisher : Academic Press
Page : 278 pages
File Size : 43,7 Mb
Release : 2019-06-11
Category : Medical
ISBN : 9780128167953

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Introduction to Addiction by George F. Koob,Michael A. Arends,Mandy L. McCracken,Michel Le Moal Pdf

Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse. Provides neurobiological theories on how addiction works Explains addiction cycle stages of binge, withdrawal and anticipation Reviews the role of dopamine and the frontal cortex in addiction Discusses the neurocircuitry of reward and stress Includes animal models and neuroadaptational views on addiction

Author : Wolfgang Sommer,Rainer Spanagel
Publisher : Springer Science & Business Media
Page : 721 pages
File Size : 48,7 Mb
Release : 2012-07-28
Category : Medical
ISBN : 9783642287206

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Behavioral Neurobiology of Alcohol Addiction by Wolfgang Sommer,Rainer Spanagel Pdf

The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.

Author : Antonio Noronha,Changhai Cui,Robert Adron Harris,John C. Crabbe
Publisher : Elsevier
Page : 573 pages
File Size : 50,7 Mb
Release : 2014-05-02
Category : Science
ISBN : 9780124071551

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Neurobiology of Alcohol Dependence by Antonio Noronha,Changhai Cui,Robert Adron Harris,John C. Crabbe Pdf

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Publisher : National Academies Press
Page : 330 pages
File Size : 47,8 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9780309055338

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Pathways of Addiction by Institute of Medicine,Committee on Opportunities in Drug Abuse Research Pdf

Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

Author : World Health Organization,WHO
Publisher : World Health Organization
Page : 284 pages
File Size : 48,6 Mb
Release : 2004
Category : Law
ISBN : 9789241562355

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Neuroscience of Psychoactive Substance Use and Dependence by World Health Organization,WHO Pdf

Provides an authoritative summary of current knowledge of the biological basis of substance use behaviours, including their relationship with environmental factors.

Author : Anonim
Publisher : Academic Press
Page : 490 pages
File Size : 44,5 Mb
Release : 2021-02-27
Category : Medical
ISBN : 9780128203569

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Neurobiology of Addiction and Co-Morbid Disorders by Anonim Pdf

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on the Neurobiology of Addiction and Co-Morbid Disorders