The Organic Chemistry Of Drug Synthesis Volume 7

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The Organic Chemistry of Drug Synthesis, Volume 7

Daniel Lednicer
The Organic Chemistry of Drug Synthesis Volume 7 Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 53,7 Mb
Release : 2007-12-14
Category : Science
ISBN : 9780470180662

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The Organic Chemistry of Drug Synthesis, Volume 7 by Daniel Lednicer Pdf

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

The Organic Chemistry of Drug Synthesis, Volume 7

Daniel Lednicer
The Organic Chemistry of Drug Synthesis Volume 7 Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 292 pages
File Size : 45,6 Mb
Release : 2007-10-31
Category : Science
ISBN : 9780470107508

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The Organic Chemistry of Drug Synthesis, Volume 7 by Daniel Lednicer Pdf

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

The Organic Chemistry of Drug Synthesis, 6 Volume Set

Daniel Lednicer,Lester A. Mitscher
The Organic Chemistry of Drug Synthesis 6 Volume Set Book PDF

Author : Daniel Lednicer,Lester A. Mitscher
Publisher : Wiley-Interscience
Page : 0 pages
File Size : 42,8 Mb
Release : 1998-11-18
Category : Science
ISBN : 0471333700

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The Organic Chemistry of Drug Synthesis, 6 Volume Set by Daniel Lednicer,Lester A. Mitscher Pdf

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

The Organic Chemistry of Drug Synthesis, 4 Volume Set

Daniel Lednicer,Lester A. Mitscher
The Organic Chemistry of Drug Synthesis 4 Volume Set Book PDF

Author : Daniel Lednicer,Lester A. Mitscher
Publisher : Wiley-Interscience
Page : 0 pages
File Size : 42,8 Mb
Release : 1991-01-16
Category : Science
ISBN : 0471531766

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The Organic Chemistry of Drug Synthesis, 4 Volume Set by Daniel Lednicer,Lester A. Mitscher Pdf

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Strategies for Organic Drug Synthesis and Design

Daniel Lednicer
Strategies for Organic Drug Synthesis and Design Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 700 pages
File Size : 48,7 Mb
Release : 2009-03-04
Category : Science
ISBN : 0470399597

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Strategies for Organic Drug Synthesis and Design by Daniel Lednicer Pdf

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Drug Synthesis Book Set

Jie Jack Li,Douglas S. Johnson
Drug Synthesis Book Set Book PDF

Author : Jie Jack Li,Douglas S. Johnson
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 54,8 Mb
Release : 2015-11-23
Category : Science
ISBN : 1119185653

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Drug Synthesis Book Set by Jie Jack Li,Douglas S. Johnson Pdf

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.

New Trends in Synthetic Medicinal Chemistry, Volume 7

F. Gualtieri
New Trends in Synthetic Medicinal Chemistry Volume 7 Book PDF

Author : F. Gualtieri
Publisher : Wiley-VCH
Page : 382 pages
File Size : 40,8 Mb
Release : 2000-03-22
Category : Medical
ISBN : UOM:39015050308777

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New Trends in Synthetic Medicinal Chemistry, Volume 7 by F. Gualtieri Pdf

The long-awaited volume on synthetic chemistry in the series "Methods and Principles in Medicinal Chemistry" is now available. In the pharmaceutical industry, computational methods play a major role in the discovery and development of new drugs. Yet, the SYNTHESIS of these compounds still remains the most crucial topic in drug design. Written by an internationally renowned team of authors and editors from academia and industry, this volume describes all recent developments in organic synthetic methodology which are essential for pharmaceutical research. The most modern synthetic developments of pharmacologically interesting compounds (carbohydrates and nucleotides) as well as important synthetic methods such as combinatorial chemistry, solid-phase reactions, bioassisted organic synthesis and asymmetric synthesis are critically discussed. Special emphasis is given to a hands-on practical approach which enables researchers to apply the featured methods immediately to their specific problems. Also, the detailed presentation of the topic and the selection of references will be of help to any researcher working in the laboratory.

The Art of Drug Synthesis

Douglas S. Johnson,Jie Jack Li
The Art of Drug Synthesis Book PDF

Author : Douglas S. Johnson,Jie Jack Li
Publisher : John Wiley & Sons
Page : 295 pages
File Size : 42,7 Mb
Release : 2013-02-26
Category : Science
ISBN : 9781118678466

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The Art of Drug Synthesis by Douglas S. Johnson,Jie Jack Li Pdf

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Modern Drug Synthesis

Jie Jack Li,Douglas S. Johnson
Modern Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson
Publisher : John Wiley & Sons
Page : 371 pages
File Size : 45,9 Mb
Release : 2013-03-27
Category : Science
ISBN : 9781118701249

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Modern Drug Synthesis by Jie Jack Li,Douglas S. Johnson Pdf

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

Antineoplastic Drugs

Daniel Lednicer
Antineoplastic Drugs Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 227 pages
File Size : 52,9 Mb
Release : 2015-05-06
Category : Science
ISBN : 9781118892541

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Antineoplastic Drugs by Daniel Lednicer Pdf

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman,Mark W. Holladay
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman,Mark W. Holladay
Publisher : Academic Press
Page : 537 pages
File Size : 45,9 Mb
Release : 2014-03-29
Category : Medical
ISBN : 9780123820310

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman,Mark W. Holladay Pdf

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman
Publisher : Elsevier
Page : 650 pages
File Size : 46,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080513379

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Contemporary Drug Synthesis

Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Contemporary Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 43,7 Mb
Release : 2004-12-27
Category : Science
ISBN : 9780471686736

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Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth Pdf

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

An Introduction to Drug Synthesis

Graham L. Patrick
An Introduction to Drug Synthesis Book PDF

Author : Graham L. Patrick
Publisher : Oxford University Press, USA
Page : 587 pages
File Size : 48,6 Mb
Release : 2015
Category : Science
ISBN : 9780198708438

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An Introduction to Drug Synthesis by Graham L. Patrick Pdf

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Heterocyclic Chemistry in Drug Discovery

Jie Jack Li
Heterocyclic Chemistry in Drug Discovery Book PDF

Author : Jie Jack Li
Publisher : John Wiley & Sons
Page : 688 pages
File Size : 43,7 Mb
Release : 2013-04-26
Category : Science
ISBN : 9781118354438

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Heterocyclic Chemistry in Drug Discovery by Jie Jack Li Pdf

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.