Author : Philip Yam
Publisher : Copernicus
Page : 308 pages
File Size : 40,5 Mb
Release : 2014-09-01
Category : Electronic
ISBN : 1475788185
The Pathological Protein
Philip Yam
The Pathological Protein
The Pathological Protein Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Pathological Protein book. This book definitely worth reading, it is an incredibly well-written.
The Pathological Protein
Philip Yam
Author : Philip Yam
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 49,6 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780387217550
The Pathological Protein by Philip Yam Pdf
Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. Although they have plagued humans and animals for 3 centuries, only in the last 2 decades have researchers linked them to diseases like Mad Cow. This book tells the strange story of their discovery, and the medical controversies that swirl around them. The author, Philip Yam, is a well-respected and connected journalist who is now an editor at Scientific American.
Etiology of Parkinson's Disease
Jonas H. Ellenberg,William C. Koller,James William Langston
Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 53,6 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230
Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
The Molecular and Cellular Basis of Neurodegenerative Diseases
Michael S. Wolfe
Author : Michael S. Wolfe
Publisher : Academic Press
Page : 560 pages
File Size : 54,6 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9780128113059
The Molecular and Cellular Basis of Neurodegenerative Diseases by Michael S. Wolfe Pdf
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Amyloid Proteins
Einar M. Sigurdsson
Author : Einar M. Sigurdsson
Publisher : Springer Science & Business Media
Page : 390 pages
File Size : 40,6 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592598748
Amyloid Proteins by Einar M. Sigurdsson Pdf
A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Neurodegeneration
Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Author : Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Publisher : National Academies Press
Page : 0 pages
File Size : 41,7 Mb
Release : 2013-12-26
Category : Medical
ISBN : 0309285674
Neurodegeneration by Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine Pdf
Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\'s (IOM\'s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer\'s disease, Parkinson\'s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.
Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases
Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin
Author : Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 43,9 Mb
Release : 2020-02-20
Category : Electronic
ISBN : 9782889635078
Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases by Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Dementia with Lewy Bodies
John O'Brien,David Ames,Ian McKeith,Edmond Chiu
Author : John O'Brien,David Ames,Ian McKeith,Edmond Chiu
Publisher : CRC Press
Page : 286 pages
File Size : 46,8 Mb
Release : 2005-11-29
Category : Medical
ISBN : 9780203313909
Dementia with Lewy Bodies by John O'Brien,David Ames,Ian McKeith,Edmond Chiu Pdf
Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder
Protein Misfolding, Aggregation and Conformational Diseases
Vladimir N. Uversky,Anthony Fink
Author : Vladimir N. Uversky,Anthony Fink
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 55,5 Mb
Release : 2007-05-26
Category : Medical
ISBN : 9780387365343
Protein Misfolding, Aggregation and Conformational Diseases by Vladimir N. Uversky,Anthony Fink Pdf
The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
Molecular Pathology of the Prions
Harry F. Baker
Author : Harry F. Baker
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 49,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592591343
Molecular Pathology of the Prions by Harry F. Baker Pdf
Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.
Protein Misfolding and Disease
Peter Bross,Niels Gregersen
Author : Peter Bross,Niels Gregersen
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 42,9 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592593941
Protein Misfolding and Disease by Peter Bross,Niels Gregersen Pdf
For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.
Neuropathology of Neurodegenerative Diseases Book and Online
Gabor G. Kovacs
Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 48,9 Mb
Release : 2014-12-04
Category : Medical
ISBN : 9781107442429
Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf
This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.
Intracellular Traffic and Neurodegenerative Disorders
Peter H. St.George-Hyslop,William C. Mobley
Author : Peter H. St.George-Hyslop,William C. Mobley
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 53,7 Mb
Release : 2009-02-03
Category : Medical
ISBN : 9783540879411
Intracellular Traffic and Neurodegenerative Disorders by Peter H. St.George-Hyslop,William C. Mobley Pdf
Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
J. Robin Harris
Author : J. Robin Harris
Publisher : Springer Science & Business Media
Page : 654 pages
File Size : 49,8 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9789400754164
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease by J. Robin Harris Pdf
This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.
Proteins in Normal and Pathological Urine
Yves Manuel,Jean-Pierre Revillard,Hervé Betuel
Author : Yves Manuel,Jean-Pierre Revillard,Hervé Betuel
Publisher : Unknown
Page : 380 pages
File Size : 50,6 Mb
Release : 1970
Category : Medical
ISBN : UOM:39015037518142