The Power Of High Throughput Experimentation

Author : Marion H. Emmert,Matthieu Jouffroy,David C. Leitch
Publisher : Unknown
Page : 0 pages
File Size : 41,8 Mb
Release : 2023
Category : Biopharmaceutics
ISBN : 0841297568

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The Power of High-throughput Experimentation by Marion H. Emmert,Matthieu Jouffroy,David C. Leitch Pdf

"High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design principles for how to build and implement HTE capabilities. Specific examples of high-throughput experimental design and execution in the context of organic synthesis are included. Volume 1 covers general topics, including the history of HTE and its transition from highly specialized groups to more general adoption across industry and academia, along with the current state-of-the-art with respect to high-throughput technologies, including photo- and electrochemistry, nanoscale reactions, and others. Chapters are authored by practitioners in industry and academia, showcasing how a high-throughput mindset enables rapid optimization of existing chemistries and discovery of new reactivity."--

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 52,6 Mb
Release : 2022
Category : Electronic
ISBN : 1713887916

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POWER OF HIGH-THROUGHPUT EXPERIMENTATION by Anonim Pdf

Author : Anonim
Publisher : Elsevier
Page : 196 pages
File Size : 55,5 Mb
Release : 2023-11-24
Category : Science
ISBN : 9780443186721

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New Horizons in Modern Catalysis: Five Different Perspectives by Anonim Pdf

New Horizons in Modern Catalysis: Six Different Perspectives, Volume 72 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on Carbanion-functionalized phosphines: New design elements for catalyst development, Molecular Electrocatalysts for Organic Electrosynthesis, Mechanistic aspects of secondary sphere modification in organocatalysis, Earth-Abundant Transition Metal-Catalyzed reactions with Iodine(III) reagents: from catalysis to mechanistic studies, Design of metal nanoparticles for better performance in catalysis, and Computational design of industrially relevant enzymes. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Catalysis series Acts as a comprehensive platform for experimental and theoretical researchers

Author : Stephen G. Newman
Publisher : John Wiley & Sons
Page : 500 pages
File Size : 46,7 Mb
Release : 2023-08-08
Category : Science
ISBN : 9781119855644

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Enabling Tools and Techniques for Organic Synthesis by Stephen G. Newman Pdf

ENABLING TOOLS AND TECHNIQUES FOR ORGANIC SYNTHESIS Provides the practical knowledge of how new technologies impact organic synthesis, enabling the reader to understand literature, evaluate different techniques, and solve synthetic challenges In recent years, new technologies have impacted organic chemistry to the point that they are no longer the sole domain of dedicated specialists. Computational chemistry, for example, can now be used by organic chemists to help predict outcomes, understand selectivity, and decipher mechanisms. To be prepared to solve various synthetic problems, it is increasingly important for chemists to familiarize themselves with a range of current and emerging tools and techniques. Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation provides a broad overview of contemporary research and new technologies applied to organic synthesis. Detailed chapters, written by a team of experts from academia and industry, describe different state-of-the-art techniques such as computer-assisted retrosynthesis, spectroscopy prediction with computational chemistry, high throughput experimentation for reaction screening, and optimization using Design of Experiments (DoE). Emphasizing real-world practicality, the book includes chapters on programming for synthetic chemists, machine learning (ML) in chemical synthesis, concepts and applications of computational chemistry, and more. Highlights the most recent methods in organic synthesis and describes how to employ these techniques in a reader’s own research Familiarizes readers with the application of computational chemistry and automation technology in organic synthesis Introduces synthetic chemists to electrochemistry, photochemistry, and flow chemistry Helps readers comprehend the literature, assess the strengths and limitations of each technique, and apply those tools to solve synthetic challenges Provides case studies and guided examples with graphical illustrations in each chapter Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation is an invaluable reference for scientists needing an up-to-date introduction to new tools, graduate students wanting to expand their organic chemistry skills, and instructors teaching courses in advanced techniques for organic synthesis.

Author : Xiaohua Douglas Zhang
Publisher : Cambridge University Press
Page : 223 pages
File Size : 55,6 Mb
Release : 2011-02-21
Category : Medical
ISBN : 9781139498371

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Optimal High-Throughput Screening by Xiaohua Douglas Zhang Pdf

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

Author : David A. Dillard
Publisher : Elsevier
Page : 1190 pages
File Size : 55,8 Mb
Release : 2023-06-10
Category : Technology & Engineering
ISBN : 9780323984379

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Advances in Structural Adhesive Bonding by David A. Dillard Pdf

Advances in Structural Adhesive Bonding, Second Edition reviews developments in adhesive bonding for a range of advanced structural engineering applications. This new edition has been fully revised to include the latest advances in materials, testing and modeling methods, lifecycle considerations, and industrial implementation. Sections review advances in commonly used groups of structural adhesives, covering epoxy, acrylic, anaerobic and cyanoacrylate, polyurethane, and silicone adhesives, along with toughening. Other chapters cover various types of adherends and pre-treatment methods for structural materials, including metals, plastics, composites, wood and joint design and testing, including topics such as fracture mechanics, life prediction techniques, and advanced testing methods. This is a valuable guide for all those working with structural adhesives, including those in an industrial setting, adhesive specialists, structural engineers, design engineers, R&D professionals, and scientists, as well as academic researchers and advanced students in adhesives, joining technology, materials science and mechanical engineering. Provides detailed coverage on the main adhesive groups, including epoxy, acrylic, cyanoacrylate, polyurethane and silicone adhesives Includes the latest developments across adherends, pre-treatment methods, joint design and testing, durability and lifecycle related issues Addresses environmental challenges, adhesive specification, quality control, and risk mitigation for specific industrial application areas

Author : Marc D. Porter
Publisher : John Wiley & Sons
Page : 247 pages
File Size : 48,6 Mb
Release : 2007-08-17
Category : Technology & Engineering
ISBN : 9780470140468

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Combinatorial Materials Science by Marc D. Porter Pdf

Combinatorial Materials Science describes new developments and research results in catalysts, biomaterials, and nanomaterials, together with informatics approaches to the analysis of Combinatorial Science (CombiSci) data. CombiSci has been used extensively in the pharmaceutical industry, but there is enormous potential in its application to materials design and characterization. Addressing advances and applications in both fields, Combinatorial Materials Science: Integrates the scientific fundamentals and interdisciplinary underpinnings required to develop and apply CombiSci concepts Discusses the development and use of CombiSci for the systematic and accelerated investigation of new phenomena and of the complex structure-function interplay in materials Covers the development of new library design strategies for materials processing and for high-throughput tools for rapid sampling Uses a unique, unified approach of applying combinatorial methods to unravel the non-linear structure-function relationships in diverse materials (both hard and soft), together with advances in informatics With chapters written by leading researchers in their specialty areas, this authoritative guide is a must-have resource for scientists and engineers in materials science research, biochemists, chemists, immunologists, cell biologists, polymer scientists, chemical and mechanical engineers, statisticians, and computer scientists. It is also a great text for graduate-level courses in materials science/engineering, polymer science, chemical engineering, and chemistry.

Author : Gregory S. Patience
Publisher : Elsevier
Page : 426 pages
File Size : 53,7 Mb
Release : 2017-09-08
Category : Science
ISBN : 9780444637925

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Experimental Methods and Instrumentation for Chemical Engineers by Gregory S. Patience Pdf

Experimental Methods and Instrumentation for Chemical Engineers, Second Edition, touches many aspects of engineering practice, research, and statistics. The principles of unit operations, transport phenomena, and plant design constitute the focus of chemical engineering in the latter years of the curricula. Experimental methods and instrumentation is the precursor to these subjects. This resource integrates these concepts with statistics and uncertainty analysis to define what is necessary to measure and to control, how precisely and how often.The completely updated second edition is divided into several themes related to data: metrology, notions of statistics, and design of experiments. The book then covers basic principles of sensing devices, with a brand new chapter covering force and mass, followed by pressure, temperature, flow rate, and physico-chemical properties. It continues with chapters that describe how to measure gas and liquid concentrations, how to characterize solids, and finally a new chapter on spectroscopic techniques such as UV/Vis, IR, XRD, XPS, NMR, and XAS. Throughout the book, the author integrates the concepts of uncertainty, along with a historical context and practical examples.A problem solutions manual is available from the author upon request. Includes the basics for 1st and 2nd year chemical engineers, providing a foundation for unit operations and transport phenomena Features many practical examples Offers exercises for students at the end of each chapter Includes up-to-date detailed drawings and photos of equipment

Author : Piet W. N. M. van Leeuwen
Publisher : John Wiley & Sons
Page : 318 pages
File Size : 41,9 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527621798

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Supramolecular Catalysis by Piet W. N. M. van Leeuwen Pdf

In the past few years, supramolecular chemistry has led to new approaches in homogeneous catalysis. While host-guest chemistry had already found applications in catalysis as a result of the pioneering work carried out by Professor Ronald Breslow and Nobel prizewinner Professor Jean-Marie Lehn that began some 40 years ago, the construction of catalysts by supramolecular forces has only recently become a powerful tool. This development paves the way for large numbers of new potential catalysts that can be varied in an expedient way by changing the constituting building blocks. Written by some of the leading contributors in the field, this book is intended for both industrial and academic chemists with an interest in this area of catalysis. With its discussion of topics from ligand libraries to chirality-directed self-assembly, this is a must-have for chemists with organic, catalytic and polymer backgrounds, as well as those employing such compounds in industrial processes.

Author : William C. Hannas,Huey-Meei Chang
Publisher : Taylor & Francis
Page : 382 pages
File Size : 51,5 Mb
Release : 2022-07-29
Category : History
ISBN : 9781000619409

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Chinese Power and Artificial Intelligence by William C. Hannas,Huey-Meei Chang Pdf

This book provides a comprehensive account of Chinese AI in its various facets, based on primary Chinese-language sources. China’s rise as an AI power is an event of importance to the world and a potential challenge to liberal democracies. Filling a gap in the literature, this volume is fully documented, data-driven, and presented in a scholarly format suitable for citation and for supporting downstream research, while also remaining accessible to laypersons. It brings together 15 recognized international experts to present a full treatment of Chinese artificial intelligence. The volume contains chapters on state, commercial, and foreign sources of China’s AI power; China’s AI talent, scholarship, and global standing; the impact of AI on China’s development of cutting-edge disciplines; China’s use of AI in military, cyber, and surveillance applications; AI safety, threat mitigation, and the technology’s likely trajectory. The book ends with recommendations drawn from the authors’ interactions with policymakers and specialists worldwide, aimed at encouraging AI’s healthy development in China and preparing the rest of the world to engage with it. This book will be of much interest to students of Chinese politics, science and technology studies, security studies and international relations.

Author : Chen Qu,Hanchao Liu
Publisher : Springer Nature
Page : 323 pages
File Size : 52,5 Mb
Release : 2023-11-02
Category : Computers
ISBN : 9783031371967

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Machine Learning in Molecular Sciences by Chen Qu,Hanchao Liu Pdf

Machine learning and artificial intelligence have propelled research across various molecular science disciplines thanks to the rapid progress in computing hardware, algorithms, and data accumulation. This book presents recent machine learning applications in the broad research field of molecular sciences. Written by an international group of renowned experts, this edited volume covers both the machine learning methodologies and state-of-the-art machine learning applications in a wide range of topics in molecular sciences, from electronic structure theory to nuclear dynamics of small molecules, to the design and synthesis of large organic and biological molecules. This book is a valuable resource for researchers and students interested in applying machine learning in the research of molecular sciences.

Author : Keisuke Takahashi
Publisher : Springer Nature
Page : 301 pages
File Size : 42,6 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9789819702176

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Materials Informatics and Catalysts Informatics by Keisuke Takahashi Pdf

Author : Jörg Hüser
Publisher : John Wiley & Sons
Page : 362 pages
File Size : 46,8 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527609369

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High-Throughput Screening in Drug Discovery by Jörg Hüser Pdf

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

Author : Philippe Serp,Karine Philippot
Publisher : John Wiley & Sons
Page : 741 pages
File Size : 42,7 Mb
Release : 2012-11-15
Category : Science
ISBN : 9783527656899

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Nanomaterials in Catalysis by Philippe Serp,Karine Philippot Pdf

Nanocatalysis has emerged as a field at the interface between homogeneous and heterogeneous catalysis and offers unique solutions to the demanding requirements for catalyst improvement. Heterogeneous catalysis represents one of the oldest commercial applications of nanoscience and nanoparticles of metals, semiconductors, oxides, and other compounds have been widely used for important chemical reactions. The main focus of this fi eld is the development of well-defined catalysts, which may include both metal nanoparticles and a nanomaterial as the support. These nanocatalysts should display the benefits of both homogenous and heterogeneous catalysts, such as high efficiency and selectivity, stability and easy recovery/recycling. The concept of nanocatalysis is outlined in this book and, in particular, it provides a comprehensive overview of the science of colloidal nanoparticles. A broad range of topics, from the fundamentals to applications in catalysis, are covered, without excluding micelles, nanoparticles in ionic liquids, dendrimers, nanotubes, and nanooxides, as well as modeling, and the characterization of nanocatalysts, making it an indispensable reference for both researchers at universities and professionals in industry.

Author : Vasyl Andrushko,Natalia Andrushko
Publisher : John Wiley & Sons
Page : 1836 pages
File Size : 52,8 Mb
Release : 2013-08-16
Category : Science
ISBN : 9781118628331

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Stereoselective Synthesis of Drugs and Natural Products by Vasyl Andrushko,Natalia Andrushko Pdf

Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.