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Through multiple points of resistance, The Repressed Expressed underscores how hard it is to build a community in any nation with no beneficial qualities of hope and transparency. This informative collection of essays highlights that wherever stability and order are lacking, the universal appeal is to express that which is suppressed. Also, like a map or guidebook, The Repressed Expressed indicates how people in such geographical prisons strive to transform their agitation into spiritual and political pathways, free of pain and hurt from, and anger towards a dirty and corrupted world. It thus, underpins discord and brings to the fore the authoritys penchant for heaping abuse upon those caused to live in fear. In short, The Repressed Expressed is an impressive compilation of literary evidence informing scholarship on opinions and beliefs relating to repression, its expression, and the immeasurable associated cost.
Did James Joyce, that icon of modernity, spearhead the dismantling of the Cartesian subject? Or was he a supreme example of a modern man forever divided and never fully known to himself? This volume reads the dialogue of contradictory cultural voices in Joyce’s works—revolutionary and reactionary, critical and subject to critique, marginal and central. It includes ten essays that identify repressed elements in Joyce’s writings and examine how psychic and cultural repressions persistently surface in his texts. Contributors include Joseph A. Boone, Marilyn L. Brownstein, Jay Clayton, Laura Doyle, Susan Stanford Friedman, Christine Froula, Ellen Carol Jones, Alberto Moreirias, Richard Pearce, and Robert Spoo.
The role of microRNAs in controlling protein expression noise by Jörn Schmiedel Pdf
The expression of genes is based on stochastic processes, which lead to temporal fluctuations in the number of proteins of each gene. If such fluctuations become too large they can be detrimental to the fitness of an organisms, because most cellular processes are based on the precise interaction of proteins. This PhD thesis explores the role of post-transcriptional regulatory mechanisms in the control of stochasticity in gene expression, with a focus on microRNAs, common regulators in multicellular organisms. Bioinformatic data analysis, mathematical modeling and single cell expression experiments are used to analyze the conditions under which microRNAs can lead to the reduction of fluctuations in gene expression. The central insight of this thesis is that microRNAs can indeed reduce fluctuations for most genes and that they are likely used by organisms for this purpose, thus ensuring precision to gene expression during development and the maintenance of the adult body. Der Expression von Genen liegen stochastische Prozesse zu Grunde, die zu Fluktuationen in der Menge von Proteinen eines jeden Gens führen. Zu starke Fluktuationen in Proteinmengen können für Organismen schädlich sein, da die meisten zellulären Prozesse auf der präzisen Wechselwirkung von Proteinen beruhen. Diese Dissertationsschrift befasst sich mit dem Einfluss von post-transkriptionellen Regulationsmechanismen auf die stochastischen Prozesse der Genexpression. Mittels bioinformatischer Datenanalyse, mathematischer Modellierung und gezielten Einzelzellexperimenten wird mit Fokus auf die in Mehrzellern weitverbreiteten microRNAs erforscht unter welchen Voraussetzungen Organismen post-transkriptionelle Regulation zu Verringerung von Fluktuationen benutzen können. Die zentrale Erkenntnis der vorliegenden Arbeit ist, dass microRNAs für die meisten Gene Fluktuationen verringern können und auch zu diesem Zweck genutzt werden.
RUNX Proteins in Development and Cancer by Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen Pdf
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
Author : Martin L. Privalsky Publisher : Springer Science & Business Media Page : 202 pages File Size : 54,9 Mb Release : 2013-03-09 Category : Medical ISBN : 9783662105955
Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression by Martin L. Privalsky Pdf
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.
Author : Sarah C. R. Elgin,Jerry L. Workman Publisher : Oxford University Press, USA Page : 372 pages File Size : 44,6 Mb Release : 2000 Category : Chromatin ISBN : STANFORD:36105110188013
Chromatin Structure and Gene Expression by Sarah C. R. Elgin,Jerry L. Workman Pdf
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Political Economy of Labor Repression in the United States by Andrew Kolin Pdf
This book explores the political economy of labor repression and expands the meaning of repression by looking at the relation of politics to economics throughout the course of US history. It explains how and why this relation leads to the repression of labor and considers how it develops over time from the social relation of capital and labor.
Endothelium and Cardiovascular Diseases by Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas Pdf
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Transforming Growth Factor-Beta in Cancer Therapy, Volume II by Sonia B. Jakowlew Pdf
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.
International Cinema and the Girl by Fiona Handyside Pdf
From the precocious charms of Shirley Temple to the box-office behemoth Frozen and its two young female leads, Anna and Elsa, the girl has long been a figure of fascination for cinema. The symbol of (imagined) childhood innocence, the site of intrigue and nostalgia for adults, a metaphor for the precarious nature of subjectivity itself, the girl is caught between infancy and adulthood, between objectification and power. She speaks to many strands of interest for film studies: feminist questions of cinematic representation of female subjects; historical accounts of shifting images of girls and childhood in the cinema; and philosophical engagements with the possibilities for the subject in film. This collection considers the specificity of girls' experiences and their cinematic articulation through a multicultural feminist lens which cuts across the divides of popular/art-house, Western/non Western, and north/south. Drawing on examples from North and South America, Asia, Africa, and Europe, the contributors bring a new understanding of the global/local nature of girlhood and its relation to contemporary phenomena such as post-feminism, neoliberalism and queer subcultures. Containing work by established and emerging scholars, this volume explodes the narrow post-feminist canon and expands existing geographical, ethnic, and historical accounts of cinematic cultures and girlhood.
The Rhetoric of Racist Humour by Dr Simon Weaver Pdf
In today's multicultural and multireligious societies, humour and comedy often become the focus of controversy over alleged racist or offensive content, as shown, for instance, by the intense debate of Sacha Baron Cohen's characters Ali G and Borat, and the Prophet Muhammad cartoons published in the Danish newspaper Jyllands-Posten. Despite these intense debates, commentary on humour in the academy lacks a clear way of connecting the serious and the humorous, and a clear way of accounting for the serious impact of comic language. The absence of a developed 'serious' vocabulary with which to judge the humorous tends to encourage polarized debates, which fail to account for the paradoxes of humour. This book draws on the social theory of Zygmunt Baumann to examine the linguistic structure of humour, arguing that, as a form of language similar to metaphor, it is both unstable and unpredictable, and structurally prone to act rhetorically; that is, to be convincing. Deconstructing the dominant form of racism aimed at black people in the US, and that aimed at Asians in the UK, The Rhetoric of Racist Humour shows how racist humour expresses and supports racial stereotypes in the US and UK, while also exploring the forms of resistance presented by the humour of Black and Asian comedians to such stereotypes. An engaging exploration of modern, late modern and fluid or postmodern forms of humour, this book will be of interest to sociologists and scholars of cultural and media studies, as well as those working in the fields of race and ethnicity, humour and cultural theory.
The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.
