The Rise Of Mitochondria In Medicine

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The Rise of Mitochondria in Medicine

Loredana Moro
The Rise of Mitochondria in Medicine Book PDF

Author : Loredana Moro
Publisher : Unknown
Page : 322 pages
File Size : 43,6 Mb
Release : 2020-09-04
Category : Electronic
ISBN : 3039369180

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The Rise of Mitochondria in Medicine by Loredana Moro Pdf

Mitochondria are critical bioenergetic and biosynthetic machines that are essential for normal cell function. Traditionally, mitochondria have been considered the powerhouse of the cell, as they supply most of the cellular energy through oxidative phosphorylation. In addition, they supply the building blocks needed for the synthesis of cellular biomass. More recently, mitochondria have been recognized as signaling hubs that receive and transmit signals throughout the cell, thereby affecting cell functionality and fate. The signals generated by mitochondria include changes in metabolites, the NAD+/NADH ratio, ATP/ADP ratio, Ca2+, and reactive oxygen species (ROS), but our understanding of their nature, dynamics, targets, and roles in different physiopathological contexts is still under development. Mitochondrial dysfunction, which may originate from primary defects within the organelles or from stress conditions in the microenvironment, is a hallmark of many common diseases, including ischaemia-reperfusion injury, cancer, metabolic disease, and neurodegenerative disorders, and has become a major research focus in medicine. Understanding the biology of mitochondrial signaling and the role of mitochondrial dysfunction in the pathogenesis of many metabolic, degenerative, cardiovascular, and neoplastic diseases is crucial for the development of strategies aimed at therapeutically restoring mitochondrial functionality. This Special Issue presents current knowledge in the field of mitochondrial signaling in health and disease, and recent advances in mitochondrial pharmacology.

Mitochondria and the Future of Medicine

Lee Know
Mitochondria and the Future of Medicine Book PDF

Author : Lee Know
Publisher : Chelsea Green Publishing
Page : 274 pages
File Size : 48,9 Mb
Release : 2018
Category : MEDICAL
ISBN : 9781603587679

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Mitochondria and the Future of Medicine by Lee Know Pdf

With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondrial Medicine

Volkmar Weissig,Marvin Edeas
Mitochondrial Medicine Book PDF

Author : Volkmar Weissig,Marvin Edeas
Publisher : Springer Nature
Page : 456 pages
File Size : 45,5 Mb
Release : 2021-05-31
Category : Medical
ISBN : 9781071612668

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Mitochondrial Medicine by Volkmar Weissig,Marvin Edeas Pdf

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Mitochondria in Health and Disease

Paolo Bernardi,Orian S. Shirihai
Mitochondria in Health and Disease Book PDF

Author : Paolo Bernardi,Orian S. Shirihai
Publisher : Frontiers Media SA
Page : 299 pages
File Size : 54,8 Mb
Release : 2021-09-01
Category : Science
ISBN : 9782889712519

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Mitochondria in Health and Disease by Paolo Bernardi,Orian S. Shirihai Pdf

Mitochondrial biology reinvented itself and became a new world that has attracted new scientists influencing every field of biomedical research. Mitochondrial research is growing and changing, as reflected by the exponential rise in the number of conferences covering mitochondrial biology and the role of mitochondria in diseases ranging from neurodegenerative diseases,metabolic diseases and genetic muscular dystrophies toimmunopathologies and cancer. As the awareness of the essential role of mitochondria in pathology rose, a demand for new approaches to measure mitochondrial function resulted in the robust development of new forms of microscopy and spectroscopy that opened windows into previously unknown aspects of mitochondrial biology. Two Conferences provided an outstanding representation of this state of affairs, the Gordon Research Conference Mitochondrial Dynamics and Signaling (Ventura, California March 17-22, 2019) and the FASEB Conference Mitochondrial Biogenesis and Dynamics in Health and Disease (Palm Springs, California May 19-24, 2019). These conferences well reflected the explosion of the field of mitochondrial communication within the cell, between cells and across organs, as well as the budding of a new field on the definition of individual mitochondria and the identification of subtypes with diverse structural features that may serve different specific functions. Through our participation in these meetings, we conceived the idea to cover some of these topics in the Research Topic “Mitochondria in Health and Disease” of Frontiers in Physiology - Mitochondrial Research Specialty Section. Fitting the tradition of Frontiers, our contributors have generated a platform incuding both solid data and new concepts, as radical and courageous as they can be. We are pleased with the outcome and we hope that our readers will share our enthusiasm.

Advances in Mitochondrial Medicine

Roberto Scatena,Patrizia Bottoni,Bruno Giardina
Advances in Mitochondrial Medicine Book PDF

Author : Roberto Scatena,Patrizia Bottoni,Bruno Giardina
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 46,8 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9789400728684

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Advances in Mitochondrial Medicine by Roberto Scatena,Patrizia Bottoni,Bruno Giardina Pdf

Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Clinical Mitochondrial Medicine

Patrick F. Chinnery,Michael J. Keogh
Clinical Mitochondrial Medicine Book PDF

Author : Patrick F. Chinnery,Michael J. Keogh
Publisher : Cambridge University Press
Page : 229 pages
File Size : 53,6 Mb
Release : 2018-05-17
Category : Medical
ISBN : 9780521132985

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Clinical Mitochondrial Medicine by Patrick F. Chinnery,Michael J. Keogh Pdf

This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.

Mitochondria in Health and Disease

Carolyn D. Berdanier
Mitochondria in Health and Disease Book PDF

Author : Carolyn D. Berdanier
Publisher : CRC Press
Page : 640 pages
File Size : 40,5 Mb
Release : 2005-06-09
Category : Medical
ISBN : 9781420028843

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Mitochondria in Health and Disease by Carolyn D. Berdanier Pdf

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Mitochondria in Health and Diseases

Sabzali Javadov,Andrey V Kozlov,Amadou K S Camara
Mitochondria in Health and Diseases Book PDF

Author : Sabzali Javadov,Andrey V Kozlov,Amadou K S Camara
Publisher : Unknown
Page : 434 pages
File Size : 53,9 Mb
Release : 2020-09-04
Category : Electronic
ISBN : 3039363840

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Mitochondria in Health and Diseases by Sabzali Javadov,Andrey V Kozlov,Amadou K S Camara Pdf

Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Mitochondrial Medicine

Salvatore DiMauro,Michio Hirano,Eric A. Schon
Mitochondrial Medicine Book PDF

Author : Salvatore DiMauro,Michio Hirano,Eric A. Schon
Publisher : CRC Press
Page : 128 pages
File Size : 46,8 Mb
Release : 2019-11-26
Category : Electronic
ISBN : 0367446367

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Mitochondrial Medicine by Salvatore DiMauro,Michio Hirano,Eric A. Schon Pdf

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondrial Medicine

Volkmar Weissig,Marvin Edeas
Mitochondrial Medicine Book PDF

Author : Volkmar Weissig,Marvin Edeas
Publisher : Unknown
Page : 468 pages
File Size : 51,8 Mb
Release : 2021
Category : Electronic books
ISBN : 1071612700

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Mitochondrial Medicine by Volkmar Weissig,Marvin Edeas Pdf

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Mitochondrial Dysfunction

Lawrence H. Lash,Dean P. Jones
Mitochondrial Dysfunction Book PDF

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 40,9 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

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Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondrial Medicine

Salvatore DiMauro,Michio Hirano,Eric A. Schon
Mitochondrial Medicine Book PDF

Author : Salvatore DiMauro,Michio Hirano,Eric A. Schon
Publisher : CRC Press
Page : 368 pages
File Size : 45,5 Mb
Release : 2006-04-19
Category : Medical
ISBN : 1842142887

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Mitochondrial Medicine by Salvatore DiMauro,Michio Hirano,Eric A. Schon Pdf

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondrial Medicine

Volkmar Weissig,Marvin Edeas
Mitochondrial Medicine Book PDF

Author : Volkmar Weissig,Marvin Edeas
Publisher : Humana Press
Page : 480 pages
File Size : 53,7 Mb
Release : 2015-01-29
Category : Science
ISBN : 1493922580

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Mitochondrial Medicine by Volkmar Weissig,Marvin Edeas Pdf

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

Mitochondrial Medicine

Volkmar Weissig,Marvin Edeas
Mitochondrial Medicine Book PDF

Author : Volkmar Weissig,Marvin Edeas
Publisher : Humana
Page : 459 pages
File Size : 50,9 Mb
Release : 2021-06-13
Category : Science
ISBN : 1071612611

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Mitochondrial Medicine by Volkmar Weissig,Marvin Edeas Pdf

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Recent Advances in Mitocondrial Medicine and Coenzyme Q10

Anna Gvozdjáková,Germaine Cornelissen,Ram Bahadur Singh
Recent Advances in Mitocondrial Medicine and Coenzyme Q10 Book PDF

Author : Anna Gvozdjáková,Germaine Cornelissen,Ram Bahadur Singh
Publisher : Unknown
Page : 0 pages
File Size : 50,6 Mb
Release : 2018
Category : Mitochondrial pathology
ISBN : 1536131490

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Recent Advances in Mitocondrial Medicine and Coenzyme Q10 by Anna Gvozdjáková,Germaine Cornelissen,Ram Bahadur Singh Pdf

Recent Advances in Mitochondrial Medicine and Coenzyme Q10 (eds. Anna Gvozdjáková, Germaine Cornélissen, Ram B Singh) is an updated version of a book Mitochondrial Medicine (ed. A. Gvozdjáková) published by Springer, The Netherlands, in 2008. International contributors and world specialists in Mitochondrial Medicine and Coenzyme Q10 provide up-to-date knowledge in mitochondrial physiology, and review the role played by mitochondria in relation to diseases, diagnosies and therapies pertinent to various fields of medicine. This monograph covers topics related to mitochondrial physiology, mitochondrial sirtuins, supercomplexes, chronobiology, epigenetics, genetics, neurology, cardiology, nephrology, immunology, diabetology, oncology, and reproductive medicine. A chapter on the history of coenzyme Q10 focuses on the work of Prof. Frederick L Crane, discoverer of coenzyme Q10, who died in 2015. Current diagnostic methods of mitochondrial disturbances are reviewed, including a new non-invasive approach using high-resolution respirometry in human blood cells. The effectiveness of supplementary therapies of mitochondrial disturbances is examined for the case of natural antioxidants, melatonin, high protein diet, omega-3-PUFA, omega-6-PUFA, natural mineral water sources and polarized light. Targeting mitochondrial therapy involves coenzyme Q10 (ubiquinone, ubiquinol), prospective mitochondrial replacement therapy and mitochondrial transplantation. This book is intended for general medical practitioners and specialists in various fields of medicine, including neurologists, cardiologists, geneticists, nephrologists, diabetologists, lipidologists, immunologists, oncologists, pharmacists, biochemists and nutritionists. Pre- and post-graduate education physicians, pharmacists and biochemists will also benefit from material covered in this monograph.