The Role Of Dna Damage And Repair In Cell Aging

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The Role of DNA Damage and Repair in Cell Aging

B.A. Gilchrest,V.A. Bohr
The Role of DNA Damage and Repair in Cell Aging Book PDF

Author : B.A. Gilchrest,V.A. Bohr
Publisher : Elsevier
Page : 270 pages
File Size : 53,7 Mb
Release : 2001-03-09
Category : Science
ISBN : 044450494X

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The Role of DNA Damage and Repair in Cell Aging by B.A. Gilchrest,V.A. Bohr Pdf

Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

Aging of the Genome

Jan Vijg
Aging of the Genome Book PDF

Author : Jan Vijg
Publisher : OUP Oxford
Page : 384 pages
File Size : 44,6 Mb
Release : 2007-01-25
Category : Science
ISBN : 9780191524585

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Aging of the Genome by Jan Vijg Pdf

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

DNA Repair

Maddalena Mognato
DNA Repair Book PDF

Author : Maddalena Mognato
Publisher : BoD – Books on Demand
Page : 234 pages
File Size : 55,7 Mb
Release : 2019-06-05
Category : Medical
ISBN : 9781838807825

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DNA Repair by Maddalena Mognato Pdf

This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.

Aging, Sex, and DNA Repair

Bozzano G Luisa
Aging Sex and DNA Repair Book PDF

Author : Bozzano G Luisa
Publisher : Academic Press
Page : 395 pages
File Size : 53,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138772

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Aging, Sex, and DNA Repair by Bozzano G Luisa Pdf

Why organisms age and why sexual reproduction exists are major unsolved problems in biology. This book provides an integrated explanation of aging and sex based on current knowledge of DNA damage and repair. Discusses the universality of the problem of DNA damage Describes aging as a consequence of accumulated DNA damage Considers meiosis as an adaptation for DNA repair Discusses mating in eukaryotes as an adaptation for masking mutation

DNA Damage and Repair

Jac A. Nickoloff,Merl F. Hoekstra
DNA Damage and Repair Book PDF

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 1050 pages
File Size : 52,8 Mb
Release : 1998-08-12
Category : Science
ISBN : 9781592594559

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

DNA Repair

Allison E. Thomas
DNA Repair Book PDF

Author : Allison E. Thomas
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 53,7 Mb
Release : 2010
Category : DNA damage
ISBN : 1616689145

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DNA Repair by Allison E. Thomas Pdf

The preservation of expected life span and longevity, as well as the assurance of life succession among all species requires the integrity and faithful transcription of DNA. A dedicated machinery of DNA repair factors is responsible for reversing DNA damage across the genome. Efficient response to various effectors of DNA damage is also dependent on a complex network of sensors and mediators of stress signals which are upstream of DNA repair activation and together constitute components of the DNA damage response (DDR). This book reviews research on cell cycle checkpoints as essential mechanisms for safeguarding genome stability; nucleotide excision repair (NER) which recognises and removes bulky DNA damage that leads to DNA double-helix distortion and others.

Cell Aging: Molecular Mechanisms and Implications for Disease

Christian Behl,Christine Ziegler
Cell Aging Molecular Mechanisms and Implications for Disease Book PDF

Author : Christian Behl,Christine Ziegler
Publisher : Springer Science & Business Media
Page : 113 pages
File Size : 47,7 Mb
Release : 2013-12-18
Category : Science
ISBN : 9783642451799

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Cell Aging: Molecular Mechanisms and Implications for Disease by Christian Behl,Christine Ziegler Pdf

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Advances in DNA Damage and Repair

Miral Dizdaroglu,Ali Esat Karakaya
Advances in DNA Damage and Repair Book PDF

Author : Miral Dizdaroglu,Ali Esat Karakaya
Publisher : Springer Science & Business Media
Page : 528 pages
File Size : 52,8 Mb
Release : 1999-02-28
Category : Medical
ISBN : 0306460424

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Advances in DNA Damage and Repair by Miral Dizdaroglu,Ali Esat Karakaya Pdf

In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.

Chromosomal Instability and Aging

Fuki Hisama,Sherman M. Weissman,George M. Martin
Chromosomal Instability and Aging Book PDF

Author : Fuki Hisama,Sherman M. Weissman,George M. Martin
Publisher : CRC Press
Page : 598 pages
File Size : 40,9 Mb
Release : 2003-01-29
Category : Medical
ISBN : 9780824708566

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Chromosomal Instability and Aging by Fuki Hisama,Sherman M. Weissman,George M. Martin Pdf

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.

DNA Damage and Repair

Jac A. Nickoloff,Merl F. Hoekstra
DNA Damage and Repair Book PDF

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 650 pages
File Size : 53,8 Mb
Release : 1998-01-21
Category : Science
ISBN : UOM:39015040035902

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Continuing the tradition of presenting information on DNA damage and repair, this 3rd volume provides the latest reviews by leading researchers. They illuminate key aspects of DNA repair in mammalian systems and its relationship to human disease.

DNA

Payam Behzadi
DNA Book PDF

Author : Payam Behzadi
Publisher : BoD – Books on Demand
Page : 235 pages
File Size : 42,8 Mb
Release : 2021-05-19
Category : Medical
ISBN : 9781838810931

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DNA by Payam Behzadi Pdf

DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.

The DNA Damage Response: Implications on Cancer Formation and Treatment

Kum Kum Khanna,Yosef Shiloh
The DNA Damage Response Implications on Cancer Formation and Treatment Book PDF

Author : Kum Kum Khanna,Yosef Shiloh
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 47,9 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9789048125616

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The DNA Damage Response: Implications on Cancer Formation and Treatment by Kum Kum Khanna,Yosef Shiloh Pdf

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

SIRT6 Activities in DNA Damage Repair and Premature Aging

Shrestha Ghosh
SIRT6 Activities in DNA Damage Repair and Premature Aging Book PDF

Author : Shrestha Ghosh
Publisher : Springer Nature
Page : 151 pages
File Size : 43,9 Mb
Release : 2019-08-30
Category : Medical
ISBN : 9789813292673

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SIRT6 Activities in DNA Damage Repair and Premature Aging by Shrestha Ghosh Pdf

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.

How and why We Age

Leonard Hayflick
How and why We Age Book PDF

Author : Leonard Hayflick
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 1996
Category : Aging
ISBN : 0345401557

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How and why We Age by Leonard Hayflick Pdf

"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature

DNA Damage and Repair

A. Castellani
DNA Damage and Repair Book PDF

Author : A. Castellani
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 45,9 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781475750164

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DNA Damage and Repair by A. Castellani Pdf

The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such an exchange among scientists representing many fields of endeavor and many countries. The 37 manuscripts in this volume, presented by the invited spea kers during the four and half days of the Congress, encompass the field of DNA damage and repair. They cover biological systems ranging from mo lecules to humans and deal with damages and repair after treatment of cells with various types of radiations, chemicals, and exogenous and en dogenous oxidative damages. The Congress and its Proceedings are dedicated to two international leaders in the field of DNA damage and repair, Alexander Hollaender of the United States and Adriano Buzzati Traverso of Italy. Hollaender, who died in December 1986, was one of the first investigators to recognize the damage to DNA was important in cell killing and mutagenesis. His early work indicated that cells could recover from radiation injury.