Chromosomal Instability And Aging

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Chromosomal Instability and Aging

Fuki Hisama,Sherman M. Weissman,George M. Martin
Chromosomal Instability and Aging Book PDF

Author : Fuki Hisama,Sherman M. Weissman,George M. Martin
Publisher : CRC Press
Page : 598 pages
File Size : 46,8 Mb
Release : 2003-01-29
Category : Medical
ISBN : 9780824708566

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Chromosomal Instability and Aging by Fuki Hisama,Sherman M. Weissman,George M. Martin Pdf

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.

Chromosomal Instability and Aging

Fuki Hisama,Sherman M. Weissman,George M. Martin
Chromosomal Instability and Aging Book PDF

Author : Fuki Hisama,Sherman M. Weissman,George M. Martin
Publisher : CRC Press
Page : 600 pages
File Size : 48,9 Mb
Release : 2003-01-29
Category : Medical
ISBN : 1135546657

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Chromosomal Instability and Aging by Fuki Hisama,Sherman M. Weissman,George M. Martin Pdf

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.

Genome Stability

Igor Kovalchuk,Olga Kovalchuk
Genome Stability Book PDF

Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : Academic Press
Page : 762 pages
File Size : 50,9 Mb
Release : 2021-07-17
Category : Science
ISBN : 9780323856805

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Genome Stability by Igor Kovalchuk,Olga Kovalchuk Pdf

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Aging of the Genome

Jan Vijg
Aging of the Genome Book PDF

Author : Jan Vijg
Publisher : OUP Oxford
Page : 384 pages
File Size : 51,7 Mb
Release : 2007-01-25
Category : Science
ISBN : 9780191524585

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Aging of the Genome by Jan Vijg Pdf

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Cytogenomics

Thomas Liehr
Cytogenomics Book PDF

Author : Thomas Liehr
Publisher : Academic Press
Page : 430 pages
File Size : 42,8 Mb
Release : 2021-05-25
Category : Science
ISBN : 9780128235805

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Cytogenomics by Thomas Liehr Pdf

Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Chromosomal Abnormalities

Marcelo Larramendy,Sonia Soloneski
Chromosomal Abnormalities Book PDF

Author : Marcelo Larramendy,Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 206 pages
File Size : 52,6 Mb
Release : 2017-08-30
Category : Medical
ISBN : 9789535134732

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Chromosomal Abnormalities by Marcelo Larramendy,Sonia Soloneski Pdf

This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.

Telomeres and Telomerase in Cancer

Keiko Hiyama
Telomeres and Telomerase in Cancer Book PDF

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 52,8 Mb
Release : 2009-03-18
Category : Medical
ISBN : 9781603278799

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Telomeres and Telomerase in Cancer by Keiko Hiyama Pdf

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

DNA Replication Stress

Robert M. Brosh Jr.
DNA Replication Stress Book PDF

Author : Robert M. Brosh Jr.
Publisher : MDPI
Page : 368 pages
File Size : 55,9 Mb
Release : 2019-08-27
Category : Science
ISBN : 9783039213894

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DNA Replication Stress by Robert M. Brosh Jr. Pdf

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS

Chromosome Abnormalities and Genetic Counseling

R.J. MKinlay Gardner,Grant R Sutherland,Lisa G. Shaffer
Chromosome Abnormalities and Genetic Counseling Book PDF

Author : R.J. MKinlay Gardner,Grant R Sutherland,Lisa G. Shaffer
Publisher : OUP USA
Page : 650 pages
File Size : 53,6 Mb
Release : 2012
Category : Medical
ISBN : 9780195375336

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Chromosome Abnormalities and Genetic Counseling by R.J. MKinlay Gardner,Grant R Sutherland,Lisa G. Shaffer Pdf

Advances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.

DNA Repair

Maddalena Mognato
DNA Repair Book PDF

Author : Maddalena Mognato
Publisher : BoD – Books on Demand
Page : 234 pages
File Size : 40,6 Mb
Release : 2019-06-05
Category : Medical
ISBN : 9781838807825

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DNA Repair by Maddalena Mognato Pdf

This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.

Chromosome Biology

Rudi Appels,R. Morris,Bikram S. Gill,C. E. May
Chromosome Biology Book PDF

Author : Rudi Appels,R. Morris,Bikram S. Gill,C. E. May
Publisher : Springer Science & Business Media
Page : 405 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461554097

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Chromosome Biology by Rudi Appels,R. Morris,Bikram S. Gill,C. E. May Pdf

Chromosome biology has been brought to a golden age by phenomenal advanced in molecular genetics and techniques. This is true in the plant arena, and it is becoming increasingly true in animal studies, where chromosomes are more difficult to work with. With advanced knowledge of transformation, scientists can tell exactly where a new element enters a chromosome. Conversely, molecular biologists can make large mistakes if they do not understand the behavior of chromosomes. Written by internationally recognized experts in the field, this book is the most authoritative work on the subject to date. Students of genetics, crop science and plant breeding, entomology, animal science, and related fields will benefit from this comprehensive and practical textbook.

How and why We Age

Leonard Hayflick
How and why We Age Book PDF

Author : Leonard Hayflick
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 1996
Category : Aging
ISBN : 0345401557

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How and why We Age by Leonard Hayflick Pdf

"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature

The Causes and Consequences of Chromosomal Aberrations

Ilan R. Kirsch
The Causes and Consequences of Chromosomal Aberrations Book PDF

Author : Ilan R. Kirsch
Publisher : CRC Press
Page : 556 pages
File Size : 41,8 Mb
Release : 1992-12-21
Category : Science
ISBN : 0849388937

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The Causes and Consequences of Chromosomal Aberrations by Ilan R. Kirsch Pdf

The Causes and Consequences of Chromosomal Aberrations explores one of the most dramatic examples of genomic instability-chromosomal aberrations. It describes some of the more recent techniques used to map genes within the human genome, study chromosomal aberrations at the cellular level, and define the organization of the interphase nucleus. General overviews are provided to build a conceptual framework for understanding the generality and specificity of chromosomal aberrations. The Causes and Consequences of Chromosomal Aberrations also explores the role of recombinases and topoisomerases in the development of chromosomal aberrations. It contains studies of chromosomal aberrations, which offer separate instructive treatises on specific malignancies. The Causes and Consequences of Chromosomal Aberrations is useful to medical and graduate students, physicians, molecular biologists, and cytogeneticists. It will benefit anyone interested in the concepts, contributions, and development in the field of molecular cytogenetics.

Nephrology and Public Health Worldwide

G.B. Silva Junior,A. Ferreiro Fuentes,M. Nangaku,G. Remuzzi,C. Ronco
Nephrology and Public Health Worldwide Book PDF

Author : G.B. Silva Junior,A. Ferreiro Fuentes,M. Nangaku,G. Remuzzi,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Page : 369 pages
File Size : 50,8 Mb
Release : 2021-11-02
Category : Medical
ISBN : 9783318069372

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Nephrology and Public Health Worldwide by G.B. Silva Junior,A. Ferreiro Fuentes,M. Nangaku,G. Remuzzi,C. Ronco Pdf

Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.

Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling

Dominik Wodarz,Natalia Komarova
Computational Biology Of Cancer Lecture Notes And Mathematical Modeling Book PDF

Author : Dominik Wodarz,Natalia Komarova
Publisher : World Scientific
Page : 266 pages
File Size : 51,5 Mb
Release : 2005-01-24
Category : Science
ISBN : 9789814481878

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Computational Biology Of Cancer: Lecture Notes And Mathematical Modeling by Dominik Wodarz,Natalia Komarova Pdf

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.