The Role Of Evidence In Risk Characterization

Author : Peter M. Wiedemann,Holger Schütz
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 43,7 Mb
Release : 2008-07-29
Category : Business & Economics
ISBN : 3527320482

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The Role of Evidence in Risk Characterization by Peter M. Wiedemann,Holger Schütz Pdf

One of the few books to focus on the critical problem of the correct characterization of conflicting data for an adequate risk evaluation, this title comprehensively covers the different approaches in various research areas in the US and in Europe, while also considering the ethical implications of risk evaluation. In addition, special attention is paid to the sensitive topic of potential health risks through electromagnetic fields. Written by leading experts in the field, this is an indispensable resource for policy makers and professionals in health risk assessment.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Committee on Risk Assessment of Hazardous Air Pollutants
Publisher : National Academies Press
Page : 668 pages
File Size : 42,6 Mb
Release : 1994-01-01
Category : Science
ISBN : 9780309048941

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Science and Judgment in Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Committee on Risk Assessment of Hazardous Air Pollutants Pdf

The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Institutional Means for Assessment of Risks to Public Health
Publisher : National Academies Press
Page : 206 pages
File Size : 44,7 Mb
Release : 1983-02-01
Category : Medical
ISBN : 9780309033497

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Risk Assessment in the Federal Government by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Institutional Means for Assessment of Risks to Public Health Pdf

The regulation of potentially hazardous substances has become a controversial issue. This volume evaluates past efforts to develop and use risk assessment guidelines, reviews the experience of regulatory agencies with different administrative arrangements for risk assessment, and evaluates various proposals to modify procedures. The book's conclusions and recommendations can be applied across the entire field of environmental health.

Author : Peter M. Wiedemann,Holger Schütz
Publisher : John Wiley & Sons
Page : 239 pages
File Size : 51,9 Mb
Release : 2008-09-08
Category : Science
ISBN : 9783527622368

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The Role of Evidence in Risk Characterization by Peter M. Wiedemann,Holger Schütz Pdf

One of the few books to focus on the critical problem of the correct characterization of conflicting data for an adequate risk evaluation, this title comprehensively covers the different approaches in various research areas in the US and in Europe, while also considering the ethical implications of risk evaluation. In addition, special attention is paid to the sensitive topic of potential health risks through electromagnetic fields. Written by leading experts in the field, this is an indispensable resource for policy makers and professionals in health risk assessment.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
Publisher : National Academies Press
Page : 422 pages
File Size : 46,7 Mb
Release : 2009-03-24
Category : Political Science
ISBN : 9780309120463

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Science and Decisions by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA Pdf

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Risk Assessment Methodology
Publisher : National Academies Press
Page : 375 pages
File Size : 50,8 Mb
Release : 1993-02-01
Category : Science
ISBN : 9780309047869

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Issues in Risk Assessment by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Risk Assessment Methodology Pdf

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Possible Effects of Electromagnetic Fields on Biologic Systems
Publisher : National Academies Press
Page : 379 pages
File Size : 50,9 Mb
Release : 1997-03-18
Category : Science
ISBN : 9780309054478

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Possible Health Effects of Exposure to Residential Electric and Magnetic Fields by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Possible Effects of Electromagnetic Fields on Biologic Systems Pdf

Can the electric and magnetic fields (EMF) to which people are routinely exposed cause health effects? This volume assesses the data and draws conclusions about the consequences of human exposure to EMF. The committee examines what is known about three kinds of health effects associated with EMF: cancer, primarily childhood leukemia; reproduction and development; and neurobiological effects. This book provides a detailed discussion of hazard identification, dose-response assessment, exposure assessment, and risk characterization for each. Possible Health Effects of Exposure to Residential Electric and Magnetic Fields also discusses the tools available to measure exposure, common types of exposures, and what is known about the effects of exposure. The committee looks at correlations between EMF exposure and carcinogenesis, mutagenesis, neurobehavioral effects, reproductive and developmental effects, effects on melatonin and other neurochemicals, and effects on bone healing and stimulated cell growth.

Author : Deborah G. Mayo,Rachelle D. Hollander
Publisher : Oxford University Press
Page : 305 pages
File Size : 46,6 Mb
Release : 1994-02-17
Category : Science
ISBN : 9780195358322

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Acceptable Evidence by Deborah G. Mayo,Rachelle D. Hollander Pdf

Discussions of science and values in risk management have largely focused on how values enter into arguments about risks, that is, issues of acceptable risk. Instead this volume concentrates on how values enter into collecting, interpreting, communicating, and evaluating the evidence of risks, that is, issues of the acceptability of evidence of risk. By focusing on acceptable evidence, this volume avoids two barriers to progress. One barrier assumes that evidence of risk is largely a matter of objective scientific data and therefore uncontroversial. The other assumes that evidence of risk, being "just" a matter of values, is not amenable to reasoned critique. Denying both extremes, this volume argues for a more constructive conclusion: understanding the interrelations of scientific and value issues enables a critical scrutiny of risk assessments and better public deliberation about social choices. The contributors, distinguished philosophers, policy analysts, and natural and social scientists, analyze environmental and medical controversies, and assumptions underlying views about risk assessment and the scientific and statistical models used in risk management.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde
Publisher : National Academies Press
Page : 204 pages
File Size : 43,7 Mb
Release : 2011-05-31
Category : Science
ISBN : 9780309211963

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Pdf

Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

Author : Anonim
Publisher : Unknown
Page : 94 pages
File Size : 40,7 Mb
Release : 1998
Category : Health risk assessment
ISBN : UOM:39015043186363

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EPA 630/R by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 52,7 Mb
Release : 1988
Category : Electronic
ISBN : OCLC:1389523975

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U.S. EnvironmentaL Protection Agency by Anonim Pdf

Author : Institute of Medicine,Food and Nutrition Board
Publisher : National Academies Press
Page : 81 pages
File Size : 45,7 Mb
Release : 1999-04-07
Category : Medical
ISBN : 9780309173230

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Dietary Reference Intakes by Institute of Medicine,Food and Nutrition Board Pdf

The model for risk assessment of nutrients used to develop tolerable upper intake levels (ULs) is one of the key elements of the developing framework for Dietary Reference Intakes (DRIs). DRIs are dietary reference values for the intake of nutrients and food components by Americans and Canadians. The U.S. National Academy of Sciences recently released two reports in the series (IOM, 1997, 1998). The overall project is a comprehensive effort undertaken by the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes (DRI Committee) of the Food and Nutrition Board (FNB), Institute of Medicine, National Academy of Sciences in the United States, with active involvement of Health Canada. The DRI project is the result of significant discussion from 1991 to 1996 by the FNB regarding how to approach the growing concern that one set of quantitative estimates of recommended intakes, the Recommended Dietary Allowances (RDAs), was scientifically inappropriate to be used as the basis for many of the uses to which it had come to be applied.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates
Publisher : National Academies Press
Page : 208 pages
File Size : 51,8 Mb
Release : 2009-01-19
Category : Nature
ISBN : 9780309128414

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Phthalates and Cumulative Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates Pdf

People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

Author : National Research Council,Division on Engineering and Physical Sciences,Board on Infrastructure and the Constructed Environment,Committee for Oversight and Assessment of U.S. Department of Energy Project Management
Publisher : National Academies Press
Page : 102 pages
File Size : 40,5 Mb
Release : 2005-03-25
Category : Transportation
ISBN : 9780309095181

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The Owner's Role in Project Risk Management by National Research Council,Division on Engineering and Physical Sciences,Board on Infrastructure and the Constructed Environment,Committee for Oversight and Assessment of U.S. Department of Energy Project Management Pdf

Effective risk management is essential for the success of large projects built and operated by the Department of Energy (DOE), particularly for the one-of-a-kind projects that characterize much of its mission. To enhance DOE's risk management efforts, the department asked the NRC to prepare a summary of the most effective practices used by leading owner organizations. The study's primary objective was to provide DOE project managers with a basic understanding of both the project owner's risk management role and effective oversight of those risk management activities delegated to contractors.

Author : M. Brown,M Stringer
Publisher : Elsevier
Page : 320 pages
File Size : 41,9 Mb
Release : 2002-09-26
Category : Technology & Engineering
ISBN : 9781855736689

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Microbiological Risk Assessment in Food Processing by M. Brown,M Stringer Pdf

Microbiological risk assessment (MRA) is one of the most important recent developments in food safety management. Adopted by Codex Alimentarius and many other international bodies, it provides a structured way of identifying and assessing microbiological risks in food. Edited by two leading authorities, and with contributions by international experts in the field, Microbiological risk assessment provides a detailed coverage of the key steps in MRA and how it can be used to improve food safety.The book begins by placing MRA within the broader context of the evolution of international food safety standards.Part one introduces the key steps in MRA methodology. A series of chapters discusses each step, starting with hazard identification and characterisation before going on to consider exposure assessment and risk characterisation. Given its importance, risk communication is also covered. Part two then considers how MRA can be implemented in practice. There are chapters on implementing the results of a microbiological risk assessment and on the qualitative and quantitative tools available in carrying out a MRA. It also discusses the relationship of MRA to the use of microbiological criteria and another key tool in food safety management, Hazard Analysis and Critical Control Point (HACCP) systems.With its authoritative coverage of both principles and key issues in implementation, Microbiological risk assessment in food processing is a standard work on one of the most important aspects of food safety management. Provides a detailed coverage of the key steps in microbiological risk assessment (MRA) and how it can be used to improve food safety Places MRA within the broader context of the evolution of international food safety standards Introduces the key steps in MRA methodology, considers exposure assessment and risk characterisation, and covers risk communication