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Author : Ali A. Zarrin,Renato C. Monteiro
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 46,7 Mb
Release : 2021-02-09
Category : Medical
ISBN : 9782889664597
Topic Editor Dr. Monteiro is the co-founder of Inatherys. Topic Editor Dr. Zarrin declares no conflict of interest with regard to the Research Topic theme.
Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 55,5 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 53,6 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 40,9 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Adriano Rossi,Deborah A. Sawatzky
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 52,7 Mb
Release : 2008-03-17
Category : Medical
ISBN : 9783764375065
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Author : Qihui Shi,Wei Wei,Ziming Li
Publisher : Frontiers Media SA
Page : 124 pages
File Size : 54,5 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9782889744794
Topic Editor Qihui Shi is the scientific co-founder of JunHealth, a company aiming to developing single-cell sequencing technologies for clinical applications, and received research funding from BeiGene.
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 47,8 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 48,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 41,8 Mb
Release : 2024-06-30
Category : Electronic
ISBN : OCLC:1125727614
Author : Arseniy Yuzhalin,Anton Kutikhin
Publisher : Academic Press
Page : 361 pages
File Size : 41,7 Mb
Release : 2014-06-27
Category : Medical
ISBN : 9780128013335
Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer Categorizes and clarifies all interleukins based on their role in cancer Contains comprehensive and exhaustive information on each molecule
Author : Amy M. Fulton
Publisher : Springer Science & Business Media
Page : 181 pages
File Size : 54,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9781603272674
Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.
Author : Ane C.F. Nunes
Publisher : BoD – Books on Demand
Page : 249 pages
File Size : 55,8 Mb
Release : 2020-01-08
Category : Medical
ISBN : 9781789843576
Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection.
Author : Miyuki Azuma,Hideo Yagita
Publisher : Springer Nature
Page : 326 pages
File Size : 54,8 Mb
Release : 2019-11-22
Category : Medical
ISBN : 9789813297173
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Author : Anton G. Kutikhin,Arseniy E. Yuzhalin
Publisher : Frontiers Media SA
Page : 203 pages
File Size : 55,6 Mb
Release : 2015-10-08
Category : Electronic book
ISBN : 9782889196746
The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.
Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 47,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
