The Role Of Modern Neuro Oncology In The Treatment Of Primary Cns Tumors And Brain And Spinal Metastases
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The Role of Modern Neuro-oncology in the Treatment of Primary CNS Tumors, and Brain and Spinal Metastases by Marcos Vinicius Calfat Maldaun,Sujit Prabhu,Claudio Tatsui,Luis Souhami Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Central Nervous System Metastases by Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti Pdf
This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Brain Metastases by Jeffrey J. Raizer,Lauren E. Abrey Pdf
Brain metastases are the most dreaded complication of systemic cancer, affecting some 170,000 people a year, a far greater incidence than primary brain tumors. This book presents current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neurosurgeons, radiation oncologists, medical oncologists, and neuron-oncologists, and as an overview for physicians in training.
Neuro-Oncology E-Book by Jeremy Rees,Patrick Y Wen Pdf
Neuro-Oncology—a new title in the Blue Books of Practical Neurology series—is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist. Access comprehensive coverage of treatment for adult and pediatric conditions—including tumors of the spinal cord as well as the brain. Find coverage of recent advances easily thanks to the emphasis on the latest clinical and laboratory findings and their implications for clinical management and treatment. Apply the possibilities and outcomes of neuro-oncologic surgery within the context of neurologic practice. Address the neurologic complications of cancer and its treatment as well as of primary and secondary tumors. Tap into the global perspectives of experts from all around the world for a multi-disciplinary approach to practice.
Author : Patrick Y Wen,Eudocia Quant Lee Publisher : Elsevier Health Sciences Page : 128 pages File Size : 48,7 Mb Release : 2018-08-07 Category : Medical ISBN : 9780323614030
Neuro-oncology, An Issue of Neurologic Clinics E-Book by Patrick Y Wen,Eudocia Quant Lee Pdf
This issue of Neurologic Clinics, edited by Drs. Patrick Y. Wen and Eudocia Quant Lee, will focus on Neuro-oncology. Topiocs include, but are not limited to, Epidemiology of brain tumors, Molecular pathogenesis of brain tumors, Changes in WHO classification of brain tumors, Neurologic and medical management of brain tumors, Grade 2 and 3 Gliomas, Glioblastoma, Benign brain tumors, Primary CNS lymphoma and neurologic complications of systemic lymphoma, Pediatric brain tumors, Brain metastases, Metastatic complications of cancer, Neurologic complications of radiation therapy, Neurologic complications of systemic anticancer therapies, Neurocognitive complaints in cancer patients, and Paraneoplastic syndromes.
Brain and Spinal Tumors by Lee Roy Morgan,Feyzi Birol Sarica Pdf
Numerous new concepts and procedures are reviewed and discussed in this book and allude to the transport of drugs to the brain. New radiation concepts are also presented, plus management of toxicities associated with both treatment modalities. It is the goal of this book to provide information and data that will be useful for both researchers and practitioners to develop new approaches for the management of CNS malignancies.
Author : Lee Roy Morgan Publisher : BoD – Books on Demand Page : 216 pages File Size : 41,5 Mb Release : 2017-03-23 Category : Medical ISBN : 9789535130512
New Approaches to the Management of Primary and Secondary CNS Tumors by Lee Roy Morgan Pdf
Several new concepts are reviewed and discussed in this book and allude to the transport of drugs bound to red blood cells into the vascular blood-brain barrier and into cancer cells. Such a transport system is novel and of potential therapeutic potential. It is the goal of this book to provide information and data that will be useful for others to develop new approaches for the management of CNS malignancies.
Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen
Author : Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen Publisher : Springer Science & Business Media Page : 568 pages File Size : 54,7 Mb Release : 2010-12-15 Category : Medical ISBN : 9781607611660
Primary Central Nervous System Tumors by Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen Pdf
This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are comprised of treatment-oriented chapters covering the spectrum of gliomas and rarer tumor types. Each of these chapters presents multi-disciplinary therapeutic approaches and addresses specific disease concerns. Throughout, the authors incorporate the cutting-edge advances in molecular biology and genomics that are revolutionizing neuro-oncology. The result is an important clinical resource which provides evidence-based data and interpretation essential to intelligent therapeutic decision making.
Oxford Textbook of Neuro-Oncology by Tracy Batchelor,Ryo Nishikawa,Nancy Tarbell,Michael Weller Pdf
Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neuro-Oncology covers the pathophysiology, diagnosis, classification, and management of tumours of the nervous system. The book provides a comprehensive overview of tumour subtypes, in accordance with WHO classifications, along with management plans for adult and paediatric populations. The international team of co-editors ensures that expert commentaries on existing and wide-reaching diagnostic and treatment guidelines (including NCCN and ESMO) are accessible by a global audience.
Author : Roger J. Packer,David Schiff Publisher : John Wiley & Sons Page : 272 pages File Size : 51,9 Mb Release : 2012-04-30 Category : Medical ISBN : 9780470655757
Neuro-oncology by Roger J. Packer,David Schiff Pdf
The aim of the Neurology in Practice series is to provide a clinical 'in the office' or 'at the bedside' guide to effective patient care for neurologists in practice and in training. The tone will be practical, not academic. The working assumption is that readers want to know what (and what not) might or should be done, without over emphasis on the why. That said, it is important to review the crucial basic science necessary for effective diagnosis and management, and to provide reminders in the context of the practical chapters. The books will not be heavily referenced, in line with a more practical approach. This allows for smoother reading (and also relieves the burden of comprehensive citing from authors). Key evidence (clinical trials, Cochrane or other meta analyses) should be summarized in 'Evidence at a Glance' boxes and key references such as reviews, major papers can be provided in the 'selected bibliography' at the end of each chapter. Practical guidance will be provided through: the use of algorithms and guidelines where they are appropriate 'Tips and Tricks' boxes – hints on improving outcomes perhaps via practical technique, patient questioning etc 'Caution' warning boxes – hints on avoiding problems, perhaps via contraindications 'Science Revisited' – quick reminder of the basic science principles necessary for understanding
Neuro-oncology by A. Twijnstra,A. Keyser,B. W. Ongerboer de Visser Pdf
Intended to bridge the borderland between neurology and oncology, this book covers malignant primary and secondary central nervous system tumours. The contents consist of a number of interrelated chapters devoted to epidemiology, neuropathology, treatment and non-metastatic complications.
Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1 by Nima Rezaei,Sara Hanaei Pdf
Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
Central Nervous System Tumors by Feyzi Birol Sarica Pdf
Central nervous system (CNS) tumors are a heterogeneous group consisting of more than 100 tumor types originating from the brain, cerebellum, brain stem, spinal cord, and meninges. Despite the positive developments of recent years, especially in the treatment of high-grade brain tumors, treatment outcomes have not yet reached an acceptable level. However, due to advances in clinical and experimental studies, the genetic and molecular structures of many high-grade CNS tumors are now better understood. The World Health Organization’s 2021 Classification of CNS Tumors has aided the understanding of the genetic, molecular and immunological structures of these tumors as well as their interactions with their microenvironment. Targeted therapies and vaccines developed with immunotherapy protocols are promising developments. This book explores the natural history of CNS tumors and discusses relevant treatment protocols.
