The Role Of Selenium In Health And Disease

Author : Catherine Méplan ,David J. Hughes
Publisher : MDPI
Page : 170 pages
File Size : 44,8 Mb
Release : 2020-12-06
Category : Science
ISBN : 9783039361465

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The Role of Selenium in Health and Disease by Catherine Méplan ,David J. Hughes Pdf

“Role of selenium in health and disease”. This book contains ten articles covering recent advances in our understanding of the relationship between the essential micronutrient selenium and human health and disease. Taken together, these articles strengthen the evidence showing that selenium, as a constituent of selenoproteins, is central to biological stress responses and mechanisms commonly altered in most complex disorders. Relevant to public health concerns, this book also emphasizes the U-shaped dose-response relationship between selenium concentration and disease risk across diverse populations from Europe [articles 2,3,6], the Middle East and North Africa [9], and Taiwan [5]. This highlights the importance of personalized nutrition strategies targeted at individuals with increased risk of disease and low selenium intake. The mechanisms by which selenium status, selenoprotein expression, and inherited genetic variations in the selenium pathway interact to affect molecular pathways involved in disease development are explored in human cohorts [2,3,5-7], and in animal [4] and in vitro models [8]. Furthermore, some reports identified novel potential biomarkers of disease risk and prognosis within the selenium pathway that could further our understanding of many chronic diseases [2,3]. Overall, this book broadens our understanding of the role of selenium in chronic diseases, and provides new directions for future preventative approaches.

Author : Catherine Méplan,David J. Hughes
Publisher : Unknown
Page : 170 pages
File Size : 55,6 Mb
Release : 2020
Category : Electronic
ISBN : 3039361473

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The Role of Selenium in Health and Disease by Catherine Méplan,David J. Hughes Pdf

“Role of selenium in health and disease”. This book contains ten articles covering recent advances in our understanding of the relationship between the essential micronutrient selenium and human health and disease. Taken together, these articles strengthen the evidence showing that selenium, as a constituent of selenoproteins, is central to biological stress responses and mechanisms commonly altered in most complex disorders. Relevant to public health concerns, this book also emphasizes the U-shaped dose-response relationship between selenium concentration and disease risk across diverse populations from Europe [articles 2,3,6], the Middle East and North Africa [9], and Taiwan [5]. This highlights the importance of personalized nutrition strategies targeted at individuals with increased risk of disease and low selenium intake. The mechanisms by which selenium status, selenoprotein expression, and inherited genetic variations in the selenium pathway interact to affect molecular pathways involved in disease development are explored in human cohorts [2,3,5-7], and in animal [4] and in vitro models [8]. Furthermore, some reports identified novel potential biomarkers of disease risk and prognosis within the selenium pathway that could further our understanding of many chronic diseases [2,3]. Overall, this book broadens our understanding of the role of selenium in chronic diseases, and provides new directions for future preventative approaches.

Author : Gerald F. Jr. Combs
Publisher : Elsevier
Page : 545 pages
File Size : 42,9 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323146531

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The Role of Selenium in Nutrition by Gerald F. Jr. Combs Pdf

The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.

Author : Bernhard Michalke
Publisher : Springer
Page : 522 pages
File Size : 47,7 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9783319953908

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Selenium by Bernhard Michalke Pdf

This book summarizes the fast-growing and current knowledge about selenium interaction with cancer, diabetes, neuro-degeneration, heart disease, muscle disorders, HIV and several more. A special focus will be placed on in-depth knowledge about gene expression, selenoprotein biosynthesis, seleno-metabolism--as well as the molecular pathways, physiological roles, and the molecular action of selenium including interaction with other elements and vitamins or as Se-nanoparticles. The reader will receive the newest information regarding redox status and redox regulatory systems, specifically in relation to different glutathione peroxidases and thioredoxin-reductases as well as about cellular bioavailability and cytotoxicity, de-balanced immune response, inflammation or dietary aspects.

Author : Dolph L. Hatfield,Ulrich Schweizer,Petra A. Tsuji,Vadim N. Gladyshev
Publisher : Springer
Page : 628 pages
File Size : 45,5 Mb
Release : 2016-09-15
Category : Medical
ISBN : 9783319412832

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Selenium by Dolph L. Hatfield,Ulrich Schweizer,Petra A. Tsuji,Vadim N. Gladyshev Pdf

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

Author : H. Draper
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 47,9 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475744484

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Advances in Nutritional Research by H. Draper Pdf

The third volume of Advances in Nutritional Research continues the precedent set in previous volumes of providing authoritative reviews on the current state of knowledge with respect to major topics of ongoing nutritional research. This series is designed to be of value to investigators engaged in fundamental research as well as to those involved in its application to problems in human and animal nutrition. This volume contains three chapters on recent developments in research on inorganic elements, including a review, by F. H. Nielsen, of the evidence for a requirement for additional trace elements; a conspectus, by C. E. Casey and K. M. Hambidge, on the occurrence of trace element deficiencies in man; and a description, by M. Janghorbani and V. R. Young, of new methods of assessing the bioavailability of minerals in the diet. There are also three chapters on current topics of lipid research. One (by F. D. Sauer) is devoted to the cardiopathic effects of certain dietary monoenoic fatty acids, another (by C. Galli) to the influence of diet on prostaglandin synthesis, and the third (by H. 0. Bang and J. Dyerberg) to an analysis of the role of the unusual polyunsaturated fatty acids found in marine oils in the prevention of ischemic heart disease.

Author : Regina Brigelius-Flohe,Helmut Sies
Publisher : CRC Press
Page : 430 pages
File Size : 41,8 Mb
Release : 2015-08-14
Category : Medical
ISBN : 9781482251272

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Diversity of Selenium Functions in Health and Disease by Regina Brigelius-Flohe,Helmut Sies Pdf

Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to its medical use, and particularly to chemoprevention of cancer. It covers how Se is integrated into selenoproteins, selenium compounds with individual functions and dual functions, and unexpected links to Se such as with diabetes. The text ends with a discussion of polymorphisms and mutations in genes of selenoproteins. The chapters elucidate why studies undertaken to prevent diseases with selenium ended with disappointing outcomes and often with the opposite result, i.e. disease promotion. They show that benefit, failure, or side effects depend on: The chemical form and dose of selenium The selenium status of the individual ingesting selenium The capacity of selenium form to serve as a source for selenoprotein biosynthesis The function of selenoproteins reacting to a change in the selenium status The stage of the disease (mainly cancer) at the time point of intervention The genetic background of individuals to be treated Bringing together the accumulated evidence regarding selenium biochemistry, the book covers aspects not found in available general monographs. The narrow focus on medical uses of Se helps resolve the present confusion about potential benefits and hazards of selenium in human health. The book gives you a solid scientific basis for optimum use of selenium in preventing or treating human diseases and answering the questions: Why is selenium essential? How much is required? What are the health consequences of low selenium and can selenium reduce cancer risk?

Author : Conor Reilly
Publisher : Springer Science & Business Media
Page : 353 pages
File Size : 43,6 Mb
Release : 2013-03-09
Category : Technology & Engineering
ISBN : 9781475764949

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Selenium in Food and Health by Conor Reilly Pdf

This book provides readers with a clear and reliable account of the extraordinary story of selenium and its role in human health. It is written in a readable and user-friendly manner, and takes into account the considerable amount of fresh information that has been published over the past decade. The book if for the reader who wants to make an informed judgment about the competing claims for and against Selenium’s value as a nutritional supplement.

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee on Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Dietary Antioxidants and Related Compounds
Publisher : National Academies Press
Page : 530 pages
File Size : 42,8 Mb
Release : 2000-08-27
Category : Medical
ISBN : 9780309069496

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Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee on Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Dietary Antioxidants and Related Compounds Pdf

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.

Author : Barbara R. Cardoso,Cristiane Cominetti,Lucia A. Seale
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 50,5 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9782889744701

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Selenium, Human Health and Chronic Disease by Barbara R. Cardoso,Cristiane Cominetti,Lucia A. Seale Pdf

Author : Raymond F. Burk
Publisher : Springer
Page : 221 pages
File Size : 49,8 Mb
Release : 2011-10-04
Category : Science
ISBN : 1461225930

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Selenium in Biology and Human Health by Raymond F. Burk Pdf

Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.

Author : Dolph L. Hatfield,Marla J. Berry,Vadim N. Gladyshev
Publisher : Springer Science & Business Media
Page : 596 pages
File Size : 43,7 Mb
Release : 2011-11-13
Category : Science
ISBN : 9781461410256

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Selenium by Dolph L. Hatfield,Marla J. Berry,Vadim N. Gladyshev Pdf

Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publisher : National Academies Press
Page : 765 pages
File Size : 40,9 Mb
Release : 1989-01-01
Category : Medical
ISBN : 9780309039949

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Diet and Health by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health Pdf

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Author : Gerhard N. Schrauzer
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461246060

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Selenium by Gerhard N. Schrauzer Pdf

The papers and reviews in the present volume are in part regular contributions submitted for publication in Biological Trace Element Research, and in part invited papers from participants of the International Symposium "Present Status and Perspectives of Sele nium in Biology and Medicine," held on May 2 and 3, 1987, at the Eu ropean Academy, Nonnweiler /Trier, FRG. The Symposium focused on ecological and biomedical aspects of selenium with emphasis on the manifestations of selenium deficiency in different countries, the distribution of selenium in human organs and body fliuds, the roles of selenium in health and disease, its anti carcinogenic action, effects of supplementation, and therapeutic applications. Organized jointly by the International Association of Bioinor ganic Scientists and BioSynopsia, a Nonprofit Subsidiary of the Tech nology Center, Stuttgart, the scientific board consisted of Professors W. Hartfiel, Bonn, FRG, G.N. Schrauzer, La Jolla, CA, USA, and H. Zumkley, Muenster, FRG.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 50,7 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.