Author : Jiang Chen,Xuming Tang,Hui Liu,Zhigang Ren
Publisher : Frontiers Media SA
Page : 403 pages
File Size : 44,9 Mb
Release : 2024-01-18
Category : Medical
ISBN : 9782832542897
The Role of Tumor Microenvironment in the Development, Treatment and Prognosis of Hepatocellular Carcinoma by Jiang Chen,Xuming Tang,Hui Liu,Zhigang Ren Pdf
Primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), and other rare tumors, is the third leading cause of cancer-related mortality. Of all primary liver cancer, HCC is the most common type. Evidence has accumulated that the tumor microenvironment (TME) plays a key role in fostering or restraining tumor development. The tumor microenvironment (TME), which includes molecular, cellular, extracellular matrix(ECM), and vascular signaling pathways, is a complex ecosystem. The interaction between the tumor microenvironment and cancer cells can enhance the malignant properties of tumors, including proliferation, angiogenesis, metastasis, and therapy resistance. In addition, the tumor microenvironment can also lead to abnormal angiogenesis and promote immunosuppression. HCC has been resistant to targeted therapy and immunotherapy. Therefore, further study of the tumor microenvironment of HCC may be helpful for the development of therapeutic methods for HCC.