The Tumor Immunoenvironment

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The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 53,9 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Pawel Kalinski
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy Book PDF

Author : Pawel Kalinski
Publisher : Springer
Page : 264 pages
File Size : 41,7 Mb
Release : 2017-12-22
Category : Medical
ISBN : 9783319675770

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Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy by Pawel Kalinski Pdf

The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response

Petranel T. Ferrao,Erik W. Thompson,Andreas Behren,Robin L. Anderson
Cancer Plasticity and the Microenvironment Implications for Immunity and Therapy Response Book PDF

Author : Petranel T. Ferrao,Erik W. Thompson,Andreas Behren,Robin L. Anderson
Publisher : Frontiers Media SA
Page : 186 pages
File Size : 53,8 Mb
Release : 2019-11-01
Category : Electronic
ISBN : 9782889631155

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Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response by Petranel T. Ferrao,Erik W. Thompson,Andreas Behren,Robin L. Anderson Pdf

Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.

Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy

Patrik Andersson,Christian Ostheimer
Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy Book PDF

Author : Patrik Andersson,Christian Ostheimer
Publisher : Frontiers Media SA
Page : 316 pages
File Size : 50,5 Mb
Release : 2019-12-27
Category : Electronic
ISBN : 9782889631612

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Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy by Patrik Andersson,Christian Ostheimer Pdf

The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.

Tumor Microenvironment

Peter P. Lee,Francesco M. Marincola
Tumor Microenvironment Book PDF

Author : Peter P. Lee,Francesco M. Marincola
Publisher : Springer Nature
Page : 326 pages
File Size : 48,9 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9783030388621

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Tumor Microenvironment by Peter P. Lee,Francesco M. Marincola Pdf

This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

Interaction of Immune and Cancer Cells

Magdalena Klink
Interaction of Immune and Cancer Cells Book PDF

Author : Magdalena Klink
Publisher : Springer Science & Business Media
Page : 263 pages
File Size : 45,7 Mb
Release : 2013-11-26
Category : Medical
ISBN : 9783709113004

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Interaction of Immune and Cancer Cells by Magdalena Klink Pdf

The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology. ​

Tumor Immunology and Immunotherapy - Integrated Methods Part A

Anonim
Tumor Immunology and Immunotherapy Integrated Methods Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 43,8 Mb
Release : 2020-02-28
Category : Science
ISBN : 9780128188750

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Tumor Immunology and Immunotherapy - Integrated Methods Part A by Anonim Pdf

Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry, High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more. Authored by leaders in the field of enzymology Provides a comprehensiveness level of discussion on the field Presents a highly specialized group of topics that delve deep into new updates and future prospects

Tumor-Induced Immune Suppression

Dmitry I. Gabrilovich,Arthur Andrew Hurwitz
Tumor Induced Immune Suppression Book PDF

Author : Dmitry I. Gabrilovich,Arthur Andrew Hurwitz
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 55,7 Mb
Release : 2014-02-10
Category : Medical
ISBN : 9781489980564

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Tumor-Induced Immune Suppression by Dmitry I. Gabrilovich,Arthur Andrew Hurwitz Pdf

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.

Innate and Adaptive Immunity in the Tumor Microenvironment

Eitan Yefenof
Innate and Adaptive Immunity in the Tumor Microenvironment Book PDF

Author : Eitan Yefenof
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 42,6 Mb
Release : 2007-12-20
Category : Medical
ISBN : 9781402067501

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Innate and Adaptive Immunity in the Tumor Microenvironment by Eitan Yefenof Pdf

Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.

Tumor Immunology and Immunotherapy

Robert C. Rees
Tumor Immunology and Immunotherapy Book PDF

Author : Robert C. Rees
Publisher : Oxford University Press, USA
Page : 469 pages
File Size : 46,6 Mb
Release : 2014
Category : Medical
ISBN : 9780199676866

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Tumor Immunology and Immunotherapy by Robert C. Rees Pdf

A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Advances in Tumor Immunology and Immunotherapy

Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Advances in Tumor Immunology and Immunotherapy Book PDF

Author : Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 44,5 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9781461488095

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Advances in Tumor Immunology and Immunotherapy by Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa Pdf

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Tumor Ecosystem

Erwei Song
Tumor Ecosystem Book PDF

Author : Erwei Song
Publisher : Springer Nature
Page : 697 pages
File Size : 45,5 Mb
Release : 2023-07-20
Category : Medical
ISBN : 9789819911837

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Tumor Ecosystem by Erwei Song Pdf

This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.

In Situ Expression of Tumor Immunity

Isaac Witz
In Situ Expression of Tumor Immunity Book PDF

Author : Isaac Witz
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 50,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468436778

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In Situ Expression of Tumor Immunity by Isaac Witz Pdf

Because of several valid (and some invalid) reasons, the research field of tumor immunology has been declining in popularity. The Simplistic dogmas, articles of faith, and theories of the late 1960s and early 1970s on the immuno logical mechanisms of the host-tumor interrelationships have frequently been refuted by some of the new developments in cancer biology, cancer biochem istry, and immunology. Furthermore, some of the conventional assays used to monitor "tumor-host immune relations" did not always reflect the host's true clinical situation or his prognosis. Several approaches to immunological interven tion were less successful than expected. In addition, the concept of "immune surveillance," which was basic to many researchers in the field of cancer im munology, seemed to fall apart. Much of the criticism was based on results from solid, well-performed, and well-controlled experiments, but there was also un just criticism based on ill-conceived and badly performed studies, and on misin terpretations of experimental data. There are many misconceptions about the tumor-host relationship. It is very often assumed that tumor immunity, as expressed systemically, is truly reflected at the tumor site. Several studies reported in this volume and elsewhere indicate that such is not always the case. Certain immune effectors may be selectively prevented from reaching the tumor site or the close vicinity of the tumor cells because of mechanical or chemical barriers, whereas others may be selectively attracted to the site by chemotaxis or other mechanisms.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 42,8 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

General Principles of Tumor Immunotherapy

Howard L. Kaufman,Jedd D. Wolchok
General Principles of Tumor Immunotherapy Book PDF

Author : Howard L. Kaufman,Jedd D. Wolchok
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 45,7 Mb
Release : 2007-10-22
Category : Medical
ISBN : 9781402060861

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General Principles of Tumor Immunotherapy by Howard L. Kaufman,Jedd D. Wolchok Pdf

This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.