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Author : Edward F. Delagi
Publisher : Charles C. Thomas Publisher
Page : 580 pages
File Size : 50,9 Mb
Release : 1976
Category : Medical
ISBN : UOM:39015000862626
Author : P. Motta,A. Ruggeri
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461328315
In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.
Author : J. J. Longacre
Publisher : Unknown
Page : 538 pages
File Size : 53,6 Mb
Release : 1976
Category : Electronic
ISBN : 0398032548
Author : Peter Fratzl
Publisher : Springer Science & Business Media
Page : 516 pages
File Size : 47,8 Mb
Release : 2008-05-10
Category : Technology & Engineering
ISBN : 9780387739069
Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Author : E. Bonucci,P. Motta
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461314875
The calcified tissues have fundamental functions in the biology of organisms, not only because their strength, solidity, and elasticity permit movement and mechanical activities, and protect soft tissues against traumatic forces, but also on account of their role in mineral homeostasis. For this reason, extensive investigation in the last 30 years has provided much to explain the complex chemical and physical processes occurring in cells and matrices composing the skeleton, and their alterations in pathological conditions. The use of ultrastructural methods such as immunocytochemistry, scanning and transmission electron microscopy, cytoautoradiography, freeze/fracture etching, high voltage, etc. has proven to be of great value when applied to cells and matrix components of bone and cartilage, in spite of the technical difficulties due to the hardness of these tissues. However, available information on this subject is disseminated in a variety of scientific and medical articles. This volume is an attempt to collect together the most significant data on the ultrastructure of cartilage and bone in normalcy and pathology. Obviously, it cannot be a complete report of all these data, its principal aim being that of: a) giving a comprehensive statement of the results concerning the basic structures common to these tissues, especially collagen fibrils, noncollagenous proteins, and proteoglycans, and their relationships with the mineral substance (for which another volume of this series can also be consulted; see Ruggeri A. , Motta P. M. (eds.
Author : Miguel Angel Reina,José Antonio De Andrés,Admir Hadzic,Alberto Prats-Galino,Xavier Sala-Blanch,André A.J. van Zundert
Publisher : Springer
Page : 935 pages
File Size : 52,9 Mb
Release : 2014-11-26
Category : Medical
ISBN : 9783319095226
This is the first atlas to depict in high-resolution images the fine structure of the spinal canal, the nervous plexuses, and the peripheral nerves in relation to clinical practice. The Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine contains more than 1500 images of unsurpassed quality, most of which have never been published, including scanning electron microscopy images of neuronal ultrastructures, macroscopic sectional anatomy, and three-dimensional images reconstructed from patient imaging studies. Each chapter begins with a short introduction on the covered subject but then allows the images to embody the rest of the work; detailed text accompanies figures to guide readers through anatomy, providing evidence-based, clinically relevant information. Beyond clinically relevant anatomy, the book features regional anesthesia equipment (needles, catheters, surgical gloves) and overview of some cutting edge research instruments (e.g. scanning electron microscopy and transmission electron microscopy). Of interest to regional anesthesiologists, interventional pain physicians, and surgeons, this compendium is meant to complement texts that do not have this type of graphic material in the subjects of regional anesthesia, interventional pain management, and surgical techniques of the spine or peripheral nerves.
Author : Stephen M. King
Publisher : Academic Press
Page : 657 pages
File Size : 41,7 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780123820044
Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
Author : A. Bairati
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 55,7 Mb
Release : 2013-03-08
Category : Science
ISBN : 9781468476361
Knowledge in the field of the biology of the extracellular matrix, and in particular of collagen, has made considerable progress over the last ten years, especially in mammals, birds and ln man with respect to very important applied medical aspects. Basic knowledge in the animal kingdom overall has increased more slowly and haphazardly. We, therefore, considered it useful to organize a meeting specifically devoted to the study of the invertebrate and lower vertebrate collagens. The NATO Scientific Division financed an Advanced Research Workshop aimed at bringing together experts qualified in collagen biology (with morphological, biochemical and genetic specialization) with researchers who are currently studying collagenous tissues of invertebrates and lower vertebrates. The Medical-Biology Committee of the CNR-Rome and the University of Milan also supplied interest and support for the organization of this Meeting. The format of the workshop consisted in: 1) main lectures on the most recent aspects of collagen biology; 2) minireviews on the current knowledge of collagenous tissues in the various invertebrate phyla and in fish; 3) contributed papers on particular aspects of research in specific fields; 4) workshops on the methodology of studying collagen. As we had intended, the Workshop gave a comprehensive overview of acquired knowledge and of the present state of research actlvlty. It permitted wide interdisciplinary discussion, enabling collabora tions to be established and new research themes to be chosen. This volume contains the text of all the contributions presented at the Meeting, including posters.
Author : Xijun Wang,Aihua Zhang,Hui Sun
Publisher : Academic Press
Page : 408 pages
File Size : 53,6 Mb
Release : 2015-07-15
Category : Medical
ISBN : 9780128031186
Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications Edited by the leading experts of research related to Chinmedomics
Author : W G P Mair,F M S Tomé
Publisher : Elsevier
Page : 260 pages
File Size : 51,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483280998
Atlas of the Ultrastructure of Diseased Human Muscle provides a general view of the ultrastructure of normal and diseased human muscle. This book contains five chapters that illustrate the changes that take place in common pathological conditions and outline the patterns of change, which occur in particular diseases. Chapter 1 describes the ultrastructure of normal striated muscle and the extra-ocular and cardiac muscle. This chapter also deals with skeletal and cardiac muscle of the human fetus. Chapter 2 examines the changes in the ultrastructure of muscle fibers, including changes in myofibrils, mitochondria, lipid bodies, plasma, and basement membranes. Chapters 3 and 4 evaluate the changes in blood capillaries, interstitial tissue of muscle, nerves, motor end plates, and muscle spindles. Chapter 5 discusses the ultrastructural changes in various muscle diseases, such as denervation atrophy of muscle, muscular dystrophies, polymyositis, and congenital myopathies.
Author : L. T. Threadgold
Publisher : Elsevier
Page : 540 pages
File Size : 46,8 Mb
Release : 2017-05-03
Category : Science
ISBN : 9781483147017
The Ultrastructure of the Animal Cell examines the ultrastructure of the animal cell, with emphasis on the chemical, biochemical, and physiological aspects of the cell. Discussions are organized around the interphase cell and cell division and cover topics ranging from the general structure and molecular models of cell membranes to the ultrastructure of the nucleus and the cytosome. Changes in cell ultrastructure during embryogenesis, differentiation, and secretion are also considered. This monograph is divided into nine chapters and opens with an introduction to the principles and techniques of electron microscopy. The next section is about the interphase cell and first presents an overview of the animal cell before proceeding with an analysis of the ultrastructure of the nucleus and the cytosome, paying particular attention to the plasma membrane and associated structures; the hyaloplasm; endoplasmic reticulum; the Golgi complex; and mitochondria. The changes that occur in the ultrastructure of the cell during embryogenesis, differentiation, and secretion are also described. The last section focuses on cell division and the ultrastructure of the dividing cell. This text will be a useful resource for cell biologists, biochemists, and physiologists, as well as students and teachers of biology, biochemistry, and physiology.
Author : Dr Helena S Azevedo,Dr João F Mano,Dr João Borges
Publisher : Royal Society of Chemistry
Page : 788 pages
File Size : 46,5 Mb
Release : 2021-06-11
Category : Science
ISBN : 9781788017572
Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.
Author : Morten Karsdal
Publisher : Academic Press
Page : 272 pages
File Size : 52,6 Mb
Release : 2016-07-29
Category : Science
ISBN : 9780128098998
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
Author : Brian Eyden,S. Sankar Banerjee,Yongxin Ru,Paweł Liberski
Publisher : Springer Science & Business Media
Page : 692 pages
File Size : 43,8 Mb
Release : 2014-02-12
Category : Medical
ISBN : 9783642391682
The Ultrastructure of Human Tumours: Applications in Diagnosis and Research describes the core features as seen by transmission electron microscopy, defining the different types of cellular differentiation in tumours; this is relevant for tumour nomenclature and diagnosis, which, in turn, are important for tumour pathologists in their collaboration with oncologists for the treatment of cancer patients. The book is divided into 8 chapters. Following an introduction on technique and procedure, there are chapters on epithelial tumours, melanocytic lesions, soft-tissue and related tumours, lymphoma and leukaemia, CNS neoplasms and neuroendocrine and neuronal tumours. Each chapter includes an introductory text that puts the ultrastructural features in the context of classical pathology. The book includes many new findings and interpretations from well-known tumours, as well as ultrastructural information on several newly described tumour entities not dealt with in existing tumour ultrastructure monographs. The book will especially be of value to tumour pathologists who need to solve problem cases with the aid of electron microscopy, but also to cancer research and tissue engineering scientists working to develop anti-cancer and stem-cell-based therapies. However, even those without access to electron microscopy may also benefit from this book, since many of the images provide an ‘explanation’ of the appearances of cells, tissues and tumours familiar to pathologists and scientists from light microscopy. In this respect, it is hoped that this book will stimulate the wider use of electron microscopy in pathology. The book is comprehensively referenced, 680 pages long and lavishly illustrated with 757 figures. Dr. Brian Eyden is Consultant Clinical Scientist and Dr. S. Sankar Banerjee Consultant Histopathologist in the Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK; Dr. Yongxin Ru is Director of the Department of Electron Microscopy, Institute of Hematology and Blood Diseases Hospital, Tianjin, China; Paweł Liberski is Professor in the Department of Molecular Pathology and Neuropathology, Medical University Łódź, Poland.
Author : Marilyn J. Cipolla
Publisher : Biota Publishing
Page : 82 pages
File Size : 43,7 Mb
Release : 2016-07-28
Category : Medical
ISBN : 9781615047239
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.