Therapeutic Application Of Nitric Oxide In Cancer And Inflammatory Disorders

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Nitric Oxide in Health and Disease

Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané
Nitric Oxide in Health and Disease Book PDF

Author : Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané
Publisher : Elsevier
Page : 366 pages
File Size : 46,8 Mb
Release : 2023-04-13
Category : Computers
ISBN : 9780443133435

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Nitric Oxide in Health and Disease by Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané Pdf

Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Lucia Morbidelli,Benjamin Bonavida
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Book PDF

Author : Lucia Morbidelli,Benjamin Bonavida
Publisher : Academic Press
Page : 372 pages
File Size : 53,6 Mb
Release : 2019-02-09
Category : Medical
ISBN : 9780128172797

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders by Lucia Morbidelli,Benjamin Bonavida Pdf

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Nitric Oxide (NO) and Cancer

Benjamin Bonavida
Nitric Oxide NO and Cancer Book PDF

Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Page : 510 pages
File Size : 52,7 Mb
Release : 2010-06-16
Category : Medical
ISBN : 9781441914323

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Nitric Oxide (NO) and Cancer by Benjamin Bonavida Pdf

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disease

Valentina Rapozzi,Luigi Xodo,Benjamin Bonavida
Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disease Book PDF

Author : Valentina Rapozzi,Luigi Xodo,Benjamin Bonavida
Publisher : Academic Press
Page : 0 pages
File Size : 55,9 Mb
Release : 2024-09-15
Category : Computers
ISBN : 0443223548

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Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disease by Valentina Rapozzi,Luigi Xodo,Benjamin Bonavida Pdf

Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Diseases: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. In six parts It discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical, nitric oxide, and their applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments, and different inflammatory diseases which continue to require novel treatments. It is a valuable resource for cancer researchers, oncologists, graduate students, and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. It is highly useful for both scientists and clinicians as well as pharmaceutical companies involved in the development of new anticancer/anti-inflammatory agents.

Nitric Oxide and Cancer: Pathogenesis and Therapy

Benjamin Bonavida
Nitric Oxide and Cancer Pathogenesis and Therapy Book PDF

Author : Benjamin Bonavida
Publisher : Springer
Page : 308 pages
File Size : 48,7 Mb
Release : 2015-05-12
Category : Medical
ISBN : 9783319136110

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Nitric Oxide and Cancer: Pathogenesis and Therapy by Benjamin Bonavida Pdf

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Pathophysiology and Clinical Applications of Nitric Oxide

Gabor M. Rubanyi
Pathophysiology and Clinical Applications of Nitric Oxide Book PDF

Author : Gabor M. Rubanyi
Publisher : CRC Press
Page : 378 pages
File Size : 48,9 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303726

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Pathophysiology and Clinical Applications of Nitric Oxide by Gabor M. Rubanyi Pdf

Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Nitric Oxide (Donor/Induced) in Chemosensitization

Benjamin Bonavida
Nitric Oxide Donor Induced in Chemosensitization Book PDF

Author : Benjamin Bonavida
Publisher : Academic Press
Page : 250 pages
File Size : 48,9 Mb
Release : 2017-06-28
Category : Medical
ISBN : 9780128110218

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Nitric Oxide (Donor/Induced) in Chemosensitization by Benjamin Bonavida Pdf

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Nitric Oxide and Inflammation

Daniela Salvemini,Timothy R. Billiar,Yoram Vodovotz
Nitric Oxide and Inflammation Book PDF

Author : Daniela Salvemini,Timothy R. Billiar,Yoram Vodovotz
Publisher : Springer
Page : 308 pages
File Size : 54,7 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9783034882415

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Nitric Oxide and Inflammation by Daniela Salvemini,Timothy R. Billiar,Yoram Vodovotz Pdf

Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.

Nitric Oxide Synthase

Seyed Soheil Saeedi Saravi
Nitric Oxide Synthase Book PDF

Author : Seyed Soheil Saeedi Saravi
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 40,5 Mb
Release : 2017-05-17
Category : Science
ISBN : 9789535131632

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Nitric Oxide Synthase by Seyed Soheil Saeedi Saravi Pdf

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Anonim
Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 296 pages
File Size : 46,9 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323905565

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Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy by Anonim Pdf

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

The Role of Nitric Oxide in Type 2 Diabetes

Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran
The Role of Nitric Oxide in Type 2 Diabetes Book PDF

Author : Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran
Publisher : Bentham Science Publishers
Page : 386 pages
File Size : 44,6 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9789815079821

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The Role of Nitric Oxide in Type 2 Diabetes by Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran Pdf

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease Book PDF

Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 42,7 Mb
Release : 2007-08-06
Category : Medical
ISBN : 9780387464015

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The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia Pdf

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Anticancer Therapeutics

Sotiris Missailidis
Anticancer Therapeutics Book PDF

Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Page : 424 pages
File Size : 54,7 Mb
Release : 2008-10-13
Category : Science
ISBN : 9780470697030

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Anticancer Therapeutics by Sotiris Missailidis Pdf

Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

Nitric Oxide

Louis J. Ignarro
Nitric Oxide Book PDF

Author : Louis J. Ignarro
Publisher : Academic Press
Page : 1017 pages
File Size : 43,5 Mb
Release : 2000-09-13
Category : Science
ISBN : 0080525032

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Nitric Oxide by Louis J. Ignarro Pdf

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Herbal Medicine

Iris F. F. Benzie,Sissi Wachtel-Galor
Herbal Medicine Book PDF

Author : Iris F. F. Benzie,Sissi Wachtel-Galor
Publisher : CRC Press
Page : 500 pages
File Size : 49,7 Mb
Release : 2011-03-28
Category : Health & Fitness
ISBN : 9781439807163

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Herbal Medicine by Iris F. F. Benzie,Sissi Wachtel-Galor Pdf

The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef