Total Synthesis Of Bioactive Natural Products

Author : Sasadhar Majhi,Bhubaneswar Mandal
Publisher : World Scientific
Page : 469 pages
File Size : 40,7 Mb
Release : 2023-04-25
Category : Science
ISBN : 9789811268700

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Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products by Sasadhar Majhi,Bhubaneswar Mandal Pdf

Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.

Author : GOUTAM. BRAHMACHARI
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2022
Category : Electronic
ISBN : 3527333401

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TOTAL SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS. by GOUTAM. BRAHMACHARI Pdf

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 350 pages
File Size : 52,8 Mb
Release : 2019-04-27
Category : Science
ISBN : 9780081028230

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Total Synthesis of Bioactive Natural Products by Goutam Brahmachari Pdf

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Author : Tao Wang,Satoru Tamura,Toshio Morikawa
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 45,6 Mb
Release : 2020-10-23
Category : Science
ISBN : 9782889660865

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Discovery and Total Synthesis of Bio-functional Natural Products from Traditional Medicinal Plants by Tao Wang,Satoru Tamura,Toshio Morikawa Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Shinsuke Inuki
Publisher : Springer Science & Business Media
Page : 106 pages
File Size : 54,6 Mb
Release : 2011-11-23
Category : Science
ISBN : 4431540431

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Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by Shinsuke Inuki Pdf

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Author : Pei-Qiang Huang,Zhu-Jun Yao,Richard P. Hsung
Publisher : John Wiley & Sons
Page : 512 pages
File Size : 53,9 Mb
Release : 2018-07-20
Category : Science
ISBN : 9781118940204

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Efficiency in Natural Product Total Synthesis by Pei-Qiang Huang,Zhu-Jun Yao,Richard P. Hsung Pdf

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Author : Goutam Brahmachari
Publisher : World Scientific
Page : 695 pages
File Size : 46,9 Mb
Release : 2012
Category : Science
ISBN : 9789814335379

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Bioactive Natural Products by Goutam Brahmachari Pdf

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Author : Anonim
Publisher : Elsevier
Page : 470 pages
File Size : 54,5 Mb
Release : 2016-06-20
Category : Science
ISBN : 9780444636102

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Studies in Natural Products Chemistry by Anonim Pdf

Studies in Natural Products Chemistry, Volume 48, provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development. The series covers all aspects of the science, along with the synthesis, testing, and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, the book presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry. Provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures Focuses on the chemistry of bioactive natural products and their exciting new applications in the pharmaceutical industry Presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products Contains contributions by leading authorities in the field

Author : Xiao-Tian Liang,Wei-Shuo Fang
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 44,9 Mb
Release : 2006-03-17
Category : Science
ISBN : 9780471739333

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Medicinal Chemistry of Bioactive Natural Products by Xiao-Tian Liang,Wei-Shuo Fang Pdf

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

Author : John ApSimon,David Jonathan Goldsmith
Publisher : Unknown
Page : 552 pages
File Size : 55,7 Mb
Release : 1973
Category : Chemistry, Organic
ISBN : PSU:000021822902

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The Total Synthesis of Natural Products by John ApSimon,David Jonathan Goldsmith Pdf

Author : Shazia Anjum,Elena Soriano,José Luis Marco-Contelles
Publisher : Elsevier Inc. Chapters
Page : 538 pages
File Size : 53,9 Mb
Release : 2013-06-25
Category : Science
ISBN : 9780128084687

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Studies in Natural Products Chemistry by Shazia Anjum,Elena Soriano,José Luis Marco-Contelles Pdf

Molecular rearrangements occupy center stage in the development of organic synthesis and, consequently, in the impressive achievements that have resulted in the total synthesis of many complex natural products in the last decades. The purpose of this chapter, in this volume of a book series dedicated to the Studies in Natural Product Chemistry, is to show a set of selected and organized molecular rearrangements based on a personal choice of expertise related to the synthesis of complex bioactive molecules. Our selection addresses [3,3]-sigmatropic rearrangements, which continue to provide excellent opportunities for reaching high chemical diversity, operating in efficient synthetic schemes. [3,3]-Sigmatropic rearrangements, such as the Cope and Claisen rearrangements, are among the most basic and useful transformations in synthetic organic chemistry. This is possibly due to the fact that these rearrangements are efficient methods for the synthesis of quaternary, sterically hindered chiral centers, and for the stereoselective formation of carbon–carbon and carbon–heteroatom bonds. In addition, [3,3]-sigmatropic rearrangements can be easily integrated in, and adapted to, cascade processes as a simple method to prepare complex molecules in atom-efficient reactions. Consequently, in the context of [3,3]-sigmatropic rearrangements, we focus on the transformations of propargylic esters, whose rearrangements, in different experimental conditions, have been largely exploited for the synthesis of interesting key and useful intermediates. The rearrangements can be promoted by protic acids, Lewis acids, and noble metals such as Pt, Au, or Cu salts, or complexes that have recently emerged as the most popular and potent electrophilic activators of alkynes toward a number of nucleophilic agents, under homogeneous conditions.

Author : Jie Jack Li,E.J. Corey
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 47,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783642340659

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Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Author : John ApSimon
Publisher : Wiley-Interscience
Page : 720 pages
File Size : 44,8 Mb
Release : 2009-09-22
Category : Science
ISBN : 9780470129593

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The Total Synthesis of Natural Products by John ApSimon Pdf

The Total Synthesis of Natural Products Volume Seven Edited by John ApSimon This volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macrocyclic lactones. 1988 (0 471-88076-0) 480 pp. The Total Synthesis of Natural Products Volume Six Edited by John ApSimon Volume Six considers the total synthesis of triterpenes, carbohydrates, aromatic steroids, pyrrole pigments, and genes. 1984 (0 471-09900-7) 304 pp. The Total Synthesis of Natural Products Volume Five Edited by John ApSimon This present volume considers the total syntheses of sesquiterpenes, reflecting, in part, the heightened research activity in this area. 1983 (0 471-09808-6) 560 pp. The Total Synthesis of Natural Products Volume Four Edited by John ApSimon The fourth volume in this successful series offers synthetic approaches to a wide variety of natural products, including the synthesis of cannabinoids, natural inophores, insect pheromones, monoterpenes, and prostaglandins. 1981 (0 471-05460-7) 624 pp. The Total Synthesis of Natural Products Volume Three Edited by John ApSimon 1977 (0 471-02392-2) 576 pp. The Total Synthesis of Natural Products Volume Two Edited by John ApSimon 1973 (0 471-03252-2) 768 pp. The Total Synthesis of Natural Products Volume One Edited by John ApSimon 1973 (0 471-03251-4) 624 pp.

Author : John ApSimon
Publisher : John Wiley & Sons
Page : 548 pages
File Size : 52,9 Mb
Release : 2009-09-22
Category : Science
ISBN : 9780470129616

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The Total Synthesis of Natural Products, Volume 9 by John ApSimon Pdf

This, the ninth volume of The Total Synthesis of Natural Products series, consists of a single chapter by K. Mori examining the total synthesis of insect pheromones.

Author : Stephen Hanessian
Publisher : Pergamon
Page : 324 pages
File Size : 41,9 Mb
Release : 1983
Category : Science
ISBN : UOM:39015015993028

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Total Synthesis of Natural Products, the "Chiron" Approach by Stephen Hanessian Pdf