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Author : Tomasz Puzyn,Jerzy Leszczynski
Publisher : Royal Society of Chemistry
Page : 379 pages
File Size : 52,7 Mb
Release : 2012
Category : Science
ISBN : 9781849734530
This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques.
Author : Jerzy Leszczynski,Tomasz Puzyn
Publisher : Royal Society of Chemistry
Page : 378 pages
File Size : 43,5 Mb
Release : 2012-09-30
Category : Science
ISBN : 9781849735476
The expanding field of nanotechnology is now one of the most promising areas of science. However, because some nanoparticles can have a negative impact on human health and the environment, the design of novel materials must always be accompanied by a comprehensive risk assessment. Until now, the information on the methods available has been fragmented and incomplete. This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques. Topics covered include: benefits versus risks, carbon based nanomaterials, environmental detection and quantitative analysis, chemometric modelling, human exposure assessment, toxicity testing, nano-QSAR, risk assessment strategies, policy and regulatory frameworks.
Author : Nancy A. Monteiro-Riviere,C. Lang Tran
Publisher : CRC Press
Page : 516 pages
File Size : 43,5 Mb
Release : 2014-03-03
Category : Medical
ISBN : 9781482203875
Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines. Topics include The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies A roadmap for future research The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.
Author : Agnieszka Gajewicz,Tomasz Puzyn
Publisher : CRC Press
Page : 287 pages
File Size : 47,7 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9781000681420
The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of engineered nanoparticles, computational methods originally developed for regular (i.e., classic) chemicals cannot always be applied explicitly in nanotoxicology. Thus, the main idea of this book is to discuss the current state of the art and future needs in the development of computational modeling techniques for nanotoxicology. The book focuses on methodology. Among various in silico techniques, special attention is given to (i) computational chemistry (quantum mechanics, semi-empirical methods, density functional theory, molecular mechanics, molecular dynamics); (ii) nanochemoinformatic methods (quantitative structure–activity relationship modeling, grouping, read-across); and (iii) nanobioinformatic methods (genomics, transcriptomics, proteomics, metabolomics).
Author : Alok Dhawan,Diana Anderson,Rishi Shanker
Publisher : Royal Society of Chemistry
Page : 380 pages
File Size : 40,5 Mb
Release : 2017-11-13
Category : Science
ISBN : 9781782621584
This book fills the significant nanotoxicology and nanosafety knowledge gaps and covers a broad range of topics. It targets postgraduates, academics, and practicing industrialists.
Author : Matthew Hull,Diana Bowman
Publisher : William Andrew
Page : 463 pages
File Size : 55,9 Mb
Release : 2014-06-11
Category : Medical
ISBN : 9781455731909
Nanotechnology Environmental Health and Safety, Second Edition focuses not only on the impact of nanotechnology and the discipline of nanotoxicity, but also explains each of these disciplines through in the context of management requirements and via risk scenarios — providing an overview of regulation, risk management, and exposure. Contributors thoroughly explain environmental health and safety (EHS) issues, financial implications, foreseeable risks (e.g., exposure, dose, hazards of nanomaterials), occupational hygiene, and consumer protection. Key new chapters have been included covering eco-toxicity, nanomedicine, informatics, and future threats. New case studies have also been added, including a chapter on the impact of nanosilver on the environment, as well as an assessment of how well lessons have been learned from the past, such as in the case of asbestos. The book also makes a business case for the importance of proactive EHS management - essential reading for existing or prospective producers of nanoscale products. Practical guidance on risk management and mitigation across different legislative frameworks worldwide Reviews toxicological studies and industrial initiatives, supported by numerous case studies Includes extensive new material on the implications of nanotechnology for medicine, energy and food, as well as assessing future threats
Author : Lang Tran,Miguel A. Bañares,Robert Rallo
Publisher : Springer
Page : 360 pages
File Size : 46,6 Mb
Release : 2017-02-06
Category : Medical
ISBN : 9783319477541
In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.
Author : H. Baharvand
Publisher : John Wiley & Sons
Page : 438 pages
File Size : 52,9 Mb
Release : 2015-03-30
Category : Science
ISBN : 9781118540619
Stem Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nano-scaffolds, nano tissue engineering, applications of nanotechnology in stem cell tracking and molecular imaging, nano-devices, as well as stem cell nano-engineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields.
Author : Ratna Tantra
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 47,7 Mb
Release : 2016-03-24
Category : Science
ISBN : 9781118753842
Introduces basic knowledge for nanomaterial characterization focusing on key properties and the different analytical techniques available Provides a quick reference to different analytical methods for a given property highlighting their pros and cons Presents numerous case studies, ranging from characterizing nanomaterials in coffee creamer suspension to measurement of airborne dust exposure levels Provides an introduction to other topics that are strongly related to nanomaterial characterization e.g. synthesis, reference material and metrology Includes state of the art techniques: scanning tunneling microscopy under extreme conditions, novel strategy for biological characterization and methods to visualize multidimensional characterization data
Author : Arpana Parihar,Raju Khan,Ashok Kumar,Ajeet Kumar Kaushik,Hardik Gohel
Publisher : Academic Press
Page : 620 pages
File Size : 43,6 Mb
Release : 2022-07-13
Category : Medical
ISBN : 9780323998000
Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools
Author : Mar Viana
Publisher : Springer
Page : 236 pages
File Size : 46,7 Mb
Release : 2016-04-28
Category : Science
ISBN : 9783319239194
This volume provides an overview of the determinants of the release of and exposure to airborne nanoparticles. Whether intentionally manufactured or unintentionally generated during industrial processes, the release of nanoparticles can result in significant worker exposure, which must be dealt with adequately by means of dedicated risk assessments to ensure workplace health and safety. The book extensively discusses a number of measurement and modelling strategies available for this purpose. It also reviews the health hazardous potential of nano-sized particles and fibres, and follows the flow of engineered nanomaterials from production and use to disposal and the environment. It appeals to a wide readership, from specialists already working in the field to newcomers aiming to gain insights into this topic.
Author : Suvardhan Kanchi,Nidhi Sharotri,Rajasekhar Chokkareddy,Deepali Sharma,Falah H. Hussein
Publisher : Royal Society of Chemistry
Page : 435 pages
File Size : 55,6 Mb
Release : 2024-03-25
Category : Medical
ISBN : 9781837670826
The book focuses on how sustainable nanomaterials can help with various aspects of infectious diseases, including prevention, diagnosis, and treatment, as well as the characteristics that materials should possess in order to enter clinical trials.
Author : Enyi Ye,Zibiao Li
Publisher : Royal Society of Chemistry
Page : 359 pages
File Size : 55,8 Mb
Release : 2022-01-26
Category : Science
ISBN : 9781839162381
This book covers the photothermal effect of different categories of light-absorbing nanomaterials.
Author : Chandrabhan Verma,Chaudhery Mustansar Hussain,Eno Ebenso
Publisher : Royal Society of Chemistry
Page : 315 pages
File Size : 53,6 Mb
Release : 2022-05-09
Category : Science
ISBN : 9781839164118
This book provides readers with an overview of the properties and applications of nanomaterials and nanocomposites as corrosion inhibitors.
Author : Dastmalchi, Siavoush
Publisher : IGI Global
Page : 367 pages
File Size : 44,9 Mb
Release : 2016-05-11
Category : Medical
ISBN : 9781522503637
As the pharmaceutical industry continues to advance, new techniques in drug design are emerging. In order to deliver optimum care to patients, the development of innovative pharmacological techniques has become a widely studied topic. Applied Case Studies and Solutions in Molecular Docking-Based Drug Design is a pivotal reference source for the latest scholarly research on the progress of pharmaceutical design and computational approaches in the field of molecular docking. Highlighting innovative research perspectives and real-world applications, this book is ideally designed for professionals, researchers, practitioners, and medical chemists actively involved in computational chemistry and pharmaceutical sciences.
