Transcriptional Control Of Neural Crest Development

Author : Brian L. Nelms,Patricia A. Labosky
Publisher : Morgan & Claypool Publishers
Page : 227 pages
File Size : 42,5 Mb
Release : 2010
Category : Science
ISBN : 9781615040483

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Transcriptional Control of Neural Crest Development by Brian L. Nelms,Patricia A. Labosky Pdf

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

Author : Nicole Le Douarin,Chaya Kalcheim
Publisher : Cambridge University Press
Page : 494 pages
File Size : 44,6 Mb
Release : 1999-11-28
Category : Medical
ISBN : 0521620104

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The Neural Crest by Nicole Le Douarin,Chaya Kalcheim Pdf

A 1999 edition of a highly successful book describing comprehensive research in the study of the neural crest.

Author : Maya Sieber-Blum
Publisher : World Scientific
Page : 169 pages
File Size : 41,6 Mb
Release : 2012
Category : Medical
ISBN : 9789814343800

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Neural Crest Stem Cells by Maya Sieber-Blum Pdf

Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.

Author : Thomas Lufkin
Publisher : Elsevier
Page : 278 pages
File Size : 49,7 Mb
Release : 2003-12-03
Category : Science
ISBN : 0080497357

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Murine Homeobox Gene Control of Embryonic Patterning and Organogenesis by Thomas Lufkin Pdf

The first homeobox gene was molecular cloned nearly two decades ago, and since that time tremendous progress has been made in our understanding of the distribution of homeobox genes in the genomes of many animal species and the common functional role the encoded homeodomains play in cell-type specification, morphogenesis and development. The amino acid sequence of the homeodomain, as well as the presence of other conserved protein domains, has allowed the classification of homeodomain-containing proteins (homeoproteins) into over thirty separate families (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). In many cases a single gene has been shown to fully direct the morphogenesis and development of a complex tissue, organ or even an entire body segment. Yet how this "master" regulatory ability of homeoproteins functions at the molecular level to a large degree still remains a mystery, in part owing to our limited understanding of the nature of both homeoprotein transcriptional cofactors and even more elusively, the downstream targets of homeoprotein function. In the reviews presented here it is limited primarily to what has been learned in vertebrate systems, principally focusing on the mouse, owing to the strengths of the technical approaches currently existing in murine developmental genetics that are not yet available to the same degree in other vertebrate species. Despite this mammalian predilection, a common thread to each of these reviews is the underlying importance of what has been learned about homeoprotein function in other animal species, particularly arthropods like Drosophila.

Author : John Barton Furness,Marcello Costa
Publisher : Unknown
Page : 312 pages
File Size : 46,9 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012463215

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The Enteric Nervous System by John Barton Furness,Marcello Costa Pdf

Author : Philippa H. Francis-West,Lesley Robson,Darrell J.R. Evans
Publisher : Springer Science & Business Media
Page : 217 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642555701

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Craniofacial Development The Tissue and Molecular Interactions That Control Development of the Head by Philippa H. Francis-West,Lesley Robson,Darrell J.R. Evans Pdf

Craniofacial development is a multistep and intricate process initially involving a number of inductive interactions that control neural and neural crest development, which are followed by a series of epithelial-mesenchymal interactions that control outgrowth, patterning, and skeletal differentiation. Certain aspects of craniofacial development are unique developmental processes in higher vertebrates. First, in higher vertebrates the cranial neural crest, in contrast to the trunk neural crest, gives rise to the skeletal structures. These skeletal elements include those comprising mem brane bone and secondary cartilage, which with the exception of the clavicle are tissue types found exclusively in the head in higher vertebrates. Second, with the exception of the tongue, the origin of the musculature is distinct from other regions of the body. The body and tongue muscles are formed from the segmented epithelial somites whilst the head musculature is formed from unsegmented paraxial and prechordal mesoderm. Furthermore, the signalling cascades that control myogenic differentia tion appear to be distinct as determined by gene expression and the response of myogenic cells to growth factors. Finally, the neurogenic placodes, which give rise to the sensory organs and some cranial ganglia, are only found in the head. Over recent years, there have been significant advances in our knowledge of the molecular proc esses that control craniofacial development in a number of animal models. This has given insight into the genes that control many aspects of head development from the initial induction of the head to the final stages of differentiation.

Author : Brian K. Hall
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 55,6 Mb
Release : 2013-03-14
Category : Science
ISBN : 9781475730647

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The Neural Crest in Development and Evolution by Brian K. Hall Pdf

A discussion of the neural crest and neural crest cells, dealing with their discovery, their embryological and evolutionary origins, their cellular derivatives - in both agnathan and jawed vertebrates or gnathostomes - and the broad topics of migration and differentiation in normal development. The book also considers what goes wrong when development is misdirected by mutations, or by exposure of embryos to exogenous agents such as drugs, alcohol, or excess vitamin A, and includes discussions of tumours and syndromes and birth defects involving neural crest cells.

Author : Paul Trainor
Publisher : Academic Press
Page : 488 pages
File Size : 51,8 Mb
Release : 2013-11-23
Category : Science
ISBN : 9780124045866

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Neural Crest Cells by Paul Trainor Pdf

Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association Provides timely, comprehensive synthesis of the current knowledge of neural crest cells Covers the evolution and development of neural crest cells Includes content on applications for tissue engineering, repair and regeneration

Author : Peter Thorogood,Cheryll Tickle
Publisher : Unknown
Page : 274 pages
File Size : 43,7 Mb
Release : 1988
Category : Bones
ISBN : UOM:39015013802106

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Craniofacial Development by Peter Thorogood,Cheryll Tickle Pdf

Author : Gerald Thiel
Publisher : John Wiley & Sons
Page : 505 pages
File Size : 51,5 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527607365

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Transcription Factors in the Nervous System by Gerald Thiel Pdf

This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases. With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.

Author : Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
Publisher : Univ of California Press
Page : 469 pages
File Size : 51,7 Mb
Release : 2011-04-11
Category : Science
ISBN : 9780520948822

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Epigenetics by Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D. Pdf

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

Author : Hans J. ten Donkelaar,Martin Lammens,Akira Hori
Publisher : Springer Science & Business Media
Page : 536 pages
File Size : 44,9 Mb
Release : 2006-09-07
Category : Medical
ISBN : 9783540346593

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Clinical Neuroembryology by Hans J. ten Donkelaar,Martin Lammens,Akira Hori Pdf

Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.

Author : Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming
Publisher : Oxford University Press
Page : 850 pages
File Size : 41,7 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9780190209421

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Mayo Clinic Medical Neurosciences by Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming Pdf

Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders

Author : Anonim
Publisher : Academic Press
Page : 362 pages
File Size : 42,8 Mb
Release : 2021-05-30
Category : Science
ISBN : 9780128168349

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Amphibian Models of Development and Disease by Anonim Pdf

Amphibian Models of Development and Disease, Volume 145 in the Current Topics in Developmental Biology series, highlights new advances in the field written by an international board of experts. New chapters in this release include Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, Proteomics and metabolomics for cell lineage analysis in frog embryos, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on Amphibian Models of Development and Disease

Author : Patrick P. L. Tam,W. James Nelson,Janet Rossant
Publisher : Unknown
Page : 0 pages
File Size : 50,6 Mb
Release : 2013
Category : Science
ISBN : 1936113244

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Mammalian Development by Patrick P. L. Tam,W. James Nelson,Janet Rossant Pdf

"A subject collection from Cold Spring Harbor perspectives in biology."