Translational Approaches To Unravelling Non Motor Symptoms Of Parkinson S Disease
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Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson's Disease by Anonim Pdf
Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms - psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.
Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease by Anonim Pdf
Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology serials Updated release includes the latest information on Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases
Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Autonomic Dysfunction in Parkinson's Disease by Cristian Falup-Pecurariu,Peter Jenner Pdf
Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction. Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson’s disease Each chapter covers a specific autonomic symptom: classification, assessment, treatment Presents the newest information on each autonomic symptom in Parkinson’s disease
Author : David Crosiers,Patrick Santens,K. Ray Chaudhuri Publisher : Frontiers Media SA Page : 90 pages File Size : 41,9 Mb Release : 2021-02-17 Category : Medical ISBN : 9782889664894
Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram Pdf
Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe
Author : K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe Publisher : Oxford University Press, USA Page : 517 pages File Size : 54,7 Mb Release : 2014 Category : Medical ISBN : 9780199684243
Non-Motor Symptoms of Parkinson's Disease by K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe Pdf
Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias by Jiehui Jiang,Kuangyu Shi,Fangyu Peng,Chih-Yu Hsu,Woon-Man Kung Pdf
The Case of the Frozen Addicts by J.W. Langston,J. Palfreman Pdf
In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks
Conn's Translational Neuroscience by P. Michael Conn Pdf
Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment
An examination of the link between the vigor with which we move and the value that the brain assigns to the goal of the movement. Why do we reflexively run toward people we love, but only walk toward others? In Vigor, Reza Shadmehr and Alaa Ahmed examine the link between how the brain assigns value to things and how it controls our movements. They find that brain regions thought to be principally involved in decision making also affect movement vigor--and that brain regions thought to be principally responsible for movement also bias patterns of decision making.
The Gut-Brain Axis by Niall Hyland,Catherine Stanton Pdf
The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, Second Edition presents the most advances on how the gut microbiome influences central nervous system and brain function introduced in the first edition. The book also describes how environmental influences which affect the microbiota, including, diet, exercise, and early-life, impact on the gut-brain axis. The second edition contains new chapters on metabolomics and the gut-brain-axis; dietary factors in the maintenance of a healthy brain ; the role of gut microbes in neurodegenerative disorders; the link between exercise and the gut-brain-axis; and infant Nutrition, the microbiome and neurodevelopment. In addition, the second edition presents coverage of mechanisms underlying neurological disease; approaches to investigate the role of the microbiome in brain and behavior, and 'next generation' probiotics and prebiotics. The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, Second Edition continues to be the “go-to resource for further exploration of the microbiota. Includes new chapters focused on metabolomics and the gut-brain axis; dietary polyphenols to maintain healthier brain measures and cognitive function; the role of gut microbes in Parkinson’s Disease; the microbiota-gut-brain axis in psychosis; exploration of exercise and the gut-brain axis; and coverage of pediatric nutrition Updated chapters reflect on the most recent advances on the role of the microbiome and gut-brain axis in early-life, aging, cognition, metabolism, neurodevelopmental disorders, as well as on the enteric nervous system Addresses the role of diet and the gut-brain axis across several chapters with unique author insights and perspectives Examines common mechanisms and pathways by which the microbiota may influence brain and behavior Discusses strategies to explore the contribution of the microbiome to the gut-brain axis; methods to enhance therapeutic strategies targeted toward the microbiota; and presents a case study demonstrating a rational screening approach to increase translational success
Insights into Human Neurodegeneration: Lessons Learnt from Drosophila by Mousumi Mutsuddi,Ashim Mukherjee Pdf
This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.
