Translational Autoimmunity Volume 5

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Translational Autoimmunity, Volume 5

Nima Rezaei
Translational Autoimmunity Volume 5 Book PDF

Author : Nima Rezaei
Publisher : Elsevier
Page : 420 pages
File Size : 42,8 Mb
Release : 2022-09-13
Category : Medical
ISBN : 9780323853903

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Translational Autoimmunity, Volume 5 by Nima Rezaei Pdf

Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing. Describes challenges in the diagnosis, management and treatment of autoimmune diseases Highlights major difficulties in the diagnosis and management of autoimmune diseases Reflects important remediable deficiencies in current management Meets the needs of basic scientists, clinicians and translational scientists and industry partners

Translational Autoimmunity, Volume 6

Nima Rezaei
Translational Autoimmunity Volume 6 Book PDF

Author : Nima Rezaei
Publisher : Elsevier
Page : 630 pages
File Size : 47,8 Mb
Release : 2023-02-20
Category : Medical
ISBN : 9780323984546

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Translational Autoimmunity, Volume 6 by Nima Rezaei Pdf

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren’s syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource. Gives an introduction on rheumatic diseases, from bench to bedside Describes diagnostic laboratory tests in rheumatic diseases Meets the needs of basic scientists, clinicians and translational scientists and industry partners Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases

Translational Autoimmunity, Volume 3

Nima Rezaei
Translational Autoimmunity Volume 3 Book PDF

Author : Nima Rezaei
Publisher : Academic Press
Page : 404 pages
File Size : 48,5 Mb
Release : 2022-04-01
Category : Medical
ISBN : 9780323854160

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Translational Autoimmunity, Volume 3 by Nima Rezaei Pdf

Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions. This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Covers clinical aspects of autoimmunity and translational immunology studies in autoimmunity in different clinical settings Meets the needs of basic scientists, clinicians, translational scientists and industry partners Supported by a systematic appraisal of the most recent evidence

Translational Autoimmunity, Volume 1

Nima Rezaei
Translational Autoimmunity Volume 1 Book PDF

Author : Nima Rezaei
Publisher : Academic Press
Page : 392 pages
File Size : 50,8 Mb
Release : 2021-10-22
Category : Medical
ISBN : 9780128232774

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Translational Autoimmunity, Volume 1 by Nima Rezaei Pdf

Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions. Includes coverage of basic immunology, the clinical aspects of autoimmunity, and translational immunology studies in autoimmunity Presents key concepts supported by a systematic appraisal of the most recent evidence Assists students at all the academic levels while also being applicable to scientists who work with autoimmunity Designed for learning, teaching, review, testing, practice and research

Translational Autoimmunity, Volume 4

Nima Rezaei
Translational Autoimmunity Volume 4 Book PDF

Author : Nima Rezaei
Publisher : Academic Press
Page : 460 pages
File Size : 44,9 Mb
Release : 2022-05-01
Category : Medical
ISBN : 9780323859769

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Translational Autoimmunity, Volume 4 by Nima Rezaei Pdf

As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fourth volume of Translational Immunology Series focuses on clinical and laboratory details of autoimmune diseases which are broadly categorized into two types of organ-specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Autoimmune rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis, autoimmune rheumatic diseases such as diabetes mellitus and thyroid diseases, autoimmune neurologic diseases such as multiple sclerosis, as well as autoimmune hepatobiliary diseases, autoimmune renal diseases and autoimmune cutaneous diseases as the subject of discussion in Translational Autoimmunity: Autoimmune Diseases in Different Organs. Comprises major parts that cover basic immunology, clinical aspects of autoimmunity, and translational immunology studies in autoimmunity Each and every key concept will be mentioned after an easy background is drawn and then, will be supported by a systematic appraisal of the most recent evidence Can help students at all the academic levels while applicable to scientists who work with autoimmunity Designed for learning, teaching, review and testing, practice, and research. Hence, it might be useful for students, teachers and instructors, physicians, and researchers

Translational Autoimmunity, Volume 2

Nima Rezaei
Translational Autoimmunity Volume 2 Book PDF

Author : Nima Rezaei
Publisher : Academic Press
Page : 488 pages
File Size : 54,8 Mb
Release : 2022-01-05
Category : Medical
ISBN : 9780323859752

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Translational Autoimmunity, Volume 2 by Nima Rezaei Pdf

Translational Autoimmunity: Treatment of Autoimmune Diseases, Volume Two in the Translational Immunology series, focuses on advances in therapeutic modalities in autoimmune diseases. Efficacy and safety of not only the current biologic therapies, but also novel drug targets are discussed. Therapeutic targeting of B regulatory cells, T regulatory cells, as well as the immunomodulation effects of nanoparticles and organisms are also covered, along with our understanding and future challenges of prognostic significance of treatments in autoimmune diseases. Covers the clinical aspects and treatment of autoimmunite diseases Meets the needs of basic scientists, clinicians and translational scientists and industry partners Mentions each and every key concept after background is drawn Supported by a systematic appraisal of the most recent evidence Helps students at all academic levels, but is also applicable to scientists who work with autoimmunity

Translational Inflammation

Anonim
Translational Inflammation Book PDF

Author : Anonim
Publisher : Academic Press
Page : 294 pages
File Size : 51,8 Mb
Release : 2018-11-24
Category : Medical
ISBN : 9780128138335

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Translational Inflammation by Anonim Pdf

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

DNA Methylation and Complex Human Disease

Michel Neidhart
DNA Methylation and Complex Human Disease Book PDF

Author : Michel Neidhart
Publisher : Academic Press
Page : 552 pages
File Size : 54,5 Mb
Release : 2015-08-11
Category : Science
ISBN : 9780127999203

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DNA Methylation and Complex Human Disease by Michel Neidhart Pdf

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

The Epigenetics of Autoimmune Diseases

Moncef Zouali
The Epigenetics of Autoimmune Diseases Book PDF

Author : Moncef Zouali
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 48,7 Mb
Release : 2009-04-01
Category : Medical
ISBN : 0470743565

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The Epigenetics of Autoimmune Diseases by Moncef Zouali Pdf

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

Mosaic of Autoimmunity

Carlo Perricone,Yehuda Shoenfeld
Mosaic of Autoimmunity Book PDF

Author : Carlo Perricone,Yehuda Shoenfeld
Publisher : Academic Press
Page : 728 pages
File Size : 40,8 Mb
Release : 2019-02-15
Category : Medical
ISBN : 9780128143070

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Mosaic of Autoimmunity by Carlo Perricone,Yehuda Shoenfeld Pdf

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Protein Deimination in Human Health and Disease

Anthony P. Nicholas,Sanjoy K. Bhattacharya
Protein Deimination in Human Health and Disease Book PDF

Author : Anthony P. Nicholas,Sanjoy K. Bhattacharya
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 49,5 Mb
Release : 2013-12-03
Category : Medical
ISBN : 9781461483175

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Protein Deimination in Human Health and Disease by Anthony P. Nicholas,Sanjoy K. Bhattacharya Pdf

Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes. Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others. Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.

Autoimmune Neurology

Anonim
Autoimmune Neurology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 48,9 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467

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Autoimmune Neurology by Anonim Pdf

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Immunogenetics: A Molecular and Clinical Overview

Muneeb U. Rehman,Azher Arafah,Md. Niamat Ali,Shafat Ali
Immunogenetics A Molecular and Clinical Overview Book PDF

Author : Muneeb U. Rehman,Azher Arafah,Md. Niamat Ali,Shafat Ali
Publisher : Academic Press
Page : 412 pages
File Size : 41,7 Mb
Release : 2021-11-30
Category : Medical
ISBN : 9780323903356

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Immunogenetics: A Molecular and Clinical Overview by Muneeb U. Rehman,Azher Arafah,Md. Niamat Ali,Shafat Ali Pdf

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner

Translational Methods for Multiple Sclerosis Research

Sergiu Groppa,Sven G. Meuth
Translational Methods for Multiple Sclerosis Research Book PDF

Author : Sergiu Groppa,Sven G. Meuth
Publisher : Humana
Page : 335 pages
File Size : 48,8 Mb
Release : 2021-08-03
Category : Medical
ISBN : 1071612123

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Translational Methods for Multiple Sclerosis Research by Sergiu Groppa,Sven G. Meuth Pdf

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Intolerant Bodies

Warwick Anderson,Ian R. Mackay
Intolerant Bodies Book PDF

Author : Warwick Anderson,Ian R. Mackay
Publisher : JHU Press
Page : 265 pages
File Size : 43,5 Mb
Release : 2014-11-15
Category : Medical
ISBN : 9781421415345

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Intolerant Bodies by Warwick Anderson,Ian R. Mackay Pdf

A history of autoimmunity that validates the experience of patients while challenging assumptions about the distinction between the normal and the pathological. Winner of the NSW Premier's History Award of the Arts NSW Autoimmune diseases, which affect 5 to 10 percent of the population, are as unpredictable in their course as they are paradoxical in their cause. They produce persistent suffering as they follow a drawn-out, often lifelong, pattern of remission and recurrence. Multiple sclerosis, lupus, rheumatoid arthritis, and type 1 diabetes—the diseases considered in this book—are but a handful of the conditions that can develop when the immune system goes awry. Intolerant Bodies is a unique collaboration between Ian Mackay, one of the prominent founders of clinical immunology, and Warwick Anderson, a leading historian of twentieth-century biomedical science. The authors narrate the changing scientific understanding of the cause of autoimmunity and explore the significance of having a disease in which one’s body turns on itself. The book unfolds as a biography of a relatively new concept of pathogenesis, one that was accepted only in the 1950s. In their description of the onset, symptoms, and course of autoimmune diseases, Anderson and Mackay quote from the writings of Charles Dickens, Edgar Allan Poe, Joseph Heller, Flannery O’Connor, and other famous people who commented on or grappled with autoimmune disease. The authors also assess the work of the dedicated researchers and physicians who have struggled to understand the mysteries of autoimmunity. Connecting laboratory research, clinical medicine, social theory, and lived experience, Intolerant Bodies reveals how doctors and patients have come to terms, often reluctantly, with this novel and puzzling mechanism of disease causation.