Transmucosal Absorption Enhancers In The Drug Delivery Field

Transmucosal Absorption Enhancers In The Drug Delivery Field Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Transmucosal Absorption Enhancers In The Drug Delivery Field book. This book definitely worth reading, it is an incredibly well-written.

Transmucosal Absorption Enhancers in the Drug Delivery Field

Luca Casettari,Sam Maher,Lisbeth Illum
Transmucosal Absorption Enhancers in the Drug Delivery Field Book PDF

Author : Luca Casettari,Sam Maher,Lisbeth Illum
Publisher : MDPI
Page : 406 pages
File Size : 55,6 Mb
Release : 2020-01-07
Category : Medical
ISBN : 9783039218486

Get Book

Transmucosal Absorption Enhancers in the Drug Delivery Field by Luca Casettari,Sam Maher,Lisbeth Illum Pdf

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Transmucosal Absorption Enhancers in the Drug Delivery Field

Lisbeth Illum,Sam Maher,Luca Casettari
Transmucosal Absorption Enhancers in the Drug Delivery Field Book PDF

Author : Lisbeth Illum,Sam Maher,Luca Casettari
Publisher : Unknown
Page : 406 pages
File Size : 42,8 Mb
Release : 2020
Category : Medicine (General)
ISBN : 3039218492

Get Book

Transmucosal Absorption Enhancers in the Drug Delivery Field by Lisbeth Illum,Sam Maher,Luca Casettari Pdf

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Oral Mucosal Drug Delivery and Therapy

Michael J. Rathbone,Sevda Senel,Indiran Pather
Oral Mucosal Drug Delivery and Therapy Book PDF

Author : Michael J. Rathbone,Sevda Senel,Indiran Pather
Publisher : Springer
Page : 289 pages
File Size : 46,9 Mb
Release : 2015-03-13
Category : Medical
ISBN : 9781489975584

Get Book

Oral Mucosal Drug Delivery and Therapy by Michael J. Rathbone,Sevda Senel,Indiran Pather Pdf

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.

Enhancement in Drug Delivery

Elka Touitou,Brian W. Barry
Enhancement in Drug Delivery Book PDF

Author : Elka Touitou,Brian W. Barry
Publisher : CRC Press
Page : 656 pages
File Size : 45,7 Mb
Release : 2006-11-27
Category : Medical
ISBN : 0849332036

Get Book

Enhancement in Drug Delivery by Elka Touitou,Brian W. Barry Pdf

Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes for promoting absorption that is especially valuable to those involved with the development of pharmaceutical, cosmetic, bioengineered, and medical products, as well as graduate students looking to study this intriguing field and those professionals involved with patents and regulatory issues. Organized by routes of administration, the book is divided into eight major sections: oral, rectal, buccal/sublingual, dermal/transdermal, nasal, vaginal/uterine, ocular, and brain. It offers fundamental as well specialized information including current findings on— · Surfactant use to accelerate macromolecule input · Targeted gastrointestinal delivery and enhanced absorption of lipophilic drugs · Permeation issues in rectal absorption · Chemical means of enhancement · Carriers for enhanced delivery to and across the skin · Methods associated with breaching the skin · Promoted buccal and sublingual absorption · Emerging ocular, nasal, vaginal, and uterine delivery systems · Carriers for overcoming the blood brain barrier Those investigators primarily involved with one specific route of delivery will be able to learn of helpful concepts and find additional stimulation from reading the approaches others have used within and outside their own spheres of activity. Readers are likely to find the same enhancer tested for various administration routes and in diverse experimental models. By understanding the properties and behavior of the enhancers operating within such systems, they may well find the inspiration needed to develop appropriate enhancing delivery methods for new applications.

Drug Delivery Approaches

Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Drug Delivery Approaches Book PDF

Author : Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Page : 466 pages
File Size : 46,6 Mb
Release : 2021-08-31
Category : Medical
ISBN : 9781119772736

Get Book

Drug Delivery Approaches by Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts Pdf

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Nasal Drug Delivery

Yashwant V. Pathak,Hemant K. S. Yadav
Nasal Drug Delivery Book PDF

Author : Yashwant V. Pathak,Hemant K. S. Yadav
Publisher : Springer Nature
Page : 426 pages
File Size : 50,9 Mb
Release : 2023-03-17
Category : Science
ISBN : 9783031231124

Get Book

Nasal Drug Delivery by Yashwant V. Pathak,Hemant K. S. Yadav Pdf

This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems. In recent years, interest in using nasal passage as drug absorption site has received increased attention from formulation scientists. Nasal passages, even though a small surface area of the body as compared to other absorption passage such as Gastrointestinal tract or skin, show significant possibility for drug absorption at a quicker rate. There is also a possibility of delivering drugs to the brain using this passage and targeting drugs through the nasal passage. The book has 19 chapters addressing various aspects of nasal drug delivery systems such as an overview of anatomy and physiology of the nasal passage from a drug delivery point of view to global market opportunities for nasal drug delivery. In between, it addresses various aspects of nasal drug delivery. There are very few titles exclusively dedicated to nasal drug delivery, covering the formulation and developmental aspects, and addressing the challenges and solutions. The primary audiences for the book are graduate students in field of medicine, pharmacy and also various researchers who are working in the area of nasal drug delivery in addition to students who are specializing in field of medicine in ENT. This book provides comprehensive information on all the aspects related to the nasal drug delivery of various drug molecules.

Drug Delivery Technology

Prashant L. Pingale
Drug Delivery Technology Book PDF

Author : Prashant L. Pingale
Publisher : Walter de Gruyter GmbH & Co KG
Page : 432 pages
File Size : 40,7 Mb
Release : 2022-03-21
Category : Science
ISBN : 9783110746891

Get Book

Drug Delivery Technology by Prashant L. Pingale Pdf

Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.

Drug Absorption Studies

Carsten Ehrhardt,Kwang-Jin Kim
Drug Absorption Studies Book PDF

Author : Carsten Ehrhardt,Kwang-Jin Kim
Publisher : Springer Science & Business Media
Page : 711 pages
File Size : 55,7 Mb
Release : 2007-12-22
Category : Medical
ISBN : 9780387749013

Get Book

Drug Absorption Studies by Carsten Ehrhardt,Kwang-Jin Kim Pdf

This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.

Drug Delivery and Targeting

Anya M. Hillery,Andrew W. Lloyd,James Swarbrick
Drug Delivery and Targeting Book PDF

Author : Anya M. Hillery,Andrew W. Lloyd,James Swarbrick
Publisher : CRC Press
Page : 448 pages
File Size : 47,9 Mb
Release : 2003-09-02
Category : Medical
ISBN : 9780203302767

Get Book

Drug Delivery and Targeting by Anya M. Hillery,Andrew W. Lloyd,James Swarbrick Pdf

The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including: *Methods to optimize therapeutic efficacy, and the related commercial implications *Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination *Attempts to minimize toxicity or alter immunogenicity *Methods to achieve rate-controlled drug release and effective drug targeting *Novel and established routes of delivery *Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy This volume is indispensable for pharmaceutical students, scientists and researchers.

Drug Bioavailability

Han van de Waterbeemd,Bernard Testa
Drug Bioavailability Book PDF

Author : Han van de Waterbeemd,Bernard Testa
Publisher : John Wiley & Sons
Page : 649 pages
File Size : 48,7 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9783527623877

Get Book

Drug Bioavailability by Han van de Waterbeemd,Bernard Testa Pdf

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process. No other publication offers the same level of treatment on this crucial topic in modern drug development.

Oral Mucosal Drug Delivery

Michael J. Rathbone
Oral Mucosal Drug Delivery Book PDF

Author : Michael J. Rathbone
Publisher : CRC Press
Page : 462 pages
File Size : 51,7 Mb
Release : 1996-05-23
Category : Medical
ISBN : 0824797442

Get Book

Oral Mucosal Drug Delivery by Michael J. Rathbone Pdf

Offering comprehensive coverage of the latest developments concerning every important aspect of drug delivery to or via the oral cavity, this state-of-the-art reference examines the problems, limitations, and advantages of the oral cavity as a site for drug delivery, as well as the design, fabrication, optimization, and assessment of a wide range of local and systemic oral mucosal drug delivery systems.

Direct Nose-to-Brain Drug Delivery

Chandrakantsing Pardeshi,Eliana B. Souto
Direct Nose to Brain Drug Delivery Book PDF

Author : Chandrakantsing Pardeshi,Eliana B. Souto
Publisher : Academic Press
Page : 556 pages
File Size : 51,7 Mb
Release : 2021-06-16
Category : Business & Economics
ISBN : 9780128225233

Get Book

Direct Nose-to-Brain Drug Delivery by Chandrakantsing Pardeshi,Eliana B. Souto Pdf

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

Drug Delivery

Anya M Hillery,Kinam Park
Drug Delivery Book PDF

Author : Anya M Hillery,Kinam Park
Publisher : CRC Press
Page : 634 pages
File Size : 44,8 Mb
Release : 2016-09-15
Category : Medical
ISBN : 9781482217742

Get Book

Drug Delivery by Anya M Hillery,Kinam Park Pdf

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Novel Platforms for Drug Delivery Applications

Sangita Das,Sabu Thomas,Partha Pratim Das
Novel Platforms for Drug Delivery Applications Book PDF

Author : Sangita Das,Sabu Thomas,Partha Pratim Das
Publisher : Woodhead Publishing
Page : 695 pages
File Size : 49,5 Mb
Release : 2022-11-08
Category : Medical
ISBN : 9780323913782

Get Book

Novel Platforms for Drug Delivery Applications by Sangita Das,Sabu Thomas,Partha Pratim Das Pdf

Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ?-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety implications. This book offers an interdisciplinary approach to this fast-moving topic, bridging the disciplines of materials science and pharmacology. Provides an up-to-date single resource on novel drug delivery platforms, a rapidly evolving field of research Covers a broad range of materials, systems and release mechanisms, including in vivo and in vitro studies Describes the synthesis, properties, formulation and application of various novel drug delivery systems

Oral Delivery of Insulin

T.A. Sonia,Chandra P. Sharma
Oral Delivery of Insulin Book PDF

Author : T.A. Sonia,Chandra P. Sharma
Publisher : Elsevier
Page : 290 pages
File Size : 47,7 Mb
Release : 2014-12-11
Category : Medical
ISBN : 9781908818683

Get Book

Oral Delivery of Insulin by T.A. Sonia,Chandra P. Sharma Pdf

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field