Trends In Innate Immunity

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Trends in Innate Immunity

Arne Egesten,Axel Schmidt,Heiko Herwald
Trends in Innate Immunity Book PDF

Author : Arne Egesten,Axel Schmidt,Heiko Herwald
Publisher : Karger Medical and Scientific Publishers
Page : 221 pages
File Size : 41,6 Mb
Release : 2008
Category : Medical
ISBN : 9783805585484

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Trends in Innate Immunity by Arne Egesten,Axel Schmidt,Heiko Herwald Pdf

The last decade has witnessed the delineation of innate immunity - a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.

Innate Immunity in Health and Disease

Shailendra K. Saxena,Hridayesh Prakash
Innate Immunity in Health and Disease Book PDF

Author : Shailendra K. Saxena,Hridayesh Prakash
Publisher : BoD – Books on Demand
Page : 416 pages
File Size : 55,6 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9781838807658

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Innate Immunity in Health and Disease by Shailendra K. Saxena,Hridayesh Prakash Pdf

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Current Trends in Immunity and Respiratory Infections

Mieczyslaw Pokorski
Current Trends in Immunity and Respiratory Infections Book PDF

Author : Mieczyslaw Pokorski
Publisher : Springer
Page : 106 pages
File Size : 47,5 Mb
Release : 2018-09-21
Category : Medical
ISBN : 9783030016357

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Current Trends in Immunity and Respiratory Infections by Mieczyslaw Pokorski Pdf

The purpose of this book is to disseminate and deliberate on the latest knowledge concerning immunity and its role in protection and fight against microorganism invasion. The articles tackle both humoral and cellular immunity, and their interconnectivity. The former involves B cells that recognize invading pathogens and create the antibody-mediated response, which when memorized provides future immunity. The latter involves mostly T cells, exemplified by cytotoxic or killer cell destroying the pathogens, or helper cells stimulating B cells to produce antibodies to bind and neutralize the pathogens. T cells act through release of cytokines, interleukins, and other bioactive mediators. Neutrophils play a key role in innate immunity against bacterial infections. The process of NETosis is a recently unraveled sophisticated defense mechanism, consisting of the formation of neutrophil extracellular traps that catch, immobilize, and remove pathogens from the body. Dysfunction of immunity is indisputably conducive to the propensity for infections, particularly respiratory tract infections, as the airways are the first line of defense against invading pathogens. Pathogens can rapidly evolve and adapt to avoid detection by the immune system. The case in point is the influenza virus. The articles report on the epidemiology, diagnostics, serology, complications, and the process of acquired immunity due to vaccination against influenza and influenza-like infections in recent epidemic seasons. The book is a blend of medical research and practice. It is intended for academic scientists, research scholars, clinicians, family doctors, and healthcare professionals.

Innate Immunity

Jonathan Ewbank,Eric Vivier
Innate Immunity Book PDF

Author : Jonathan Ewbank,Eric Vivier
Publisher : Springer Science & Business Media
Page : 466 pages
File Size : 43,9 Mb
Release : 2008
Category : Medical
ISBN : 9781588297464

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Innate Immunity by Jonathan Ewbank,Eric Vivier Pdf

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Current Topics in Innate Immunity

John D. Lambris
Current Topics in Innate Immunity Book PDF

Author : John D. Lambris
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 54,5 Mb
Release : 2007-09-07
Category : Medical
ISBN : 9780387717678

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Current Topics in Innate Immunity by John D. Lambris Pdf

In the post genomic era, understanding of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. This volume covers natural killer cells, mast cells, phagocytes, toll-like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches.

Innate Immunity: Resistance and Disease-Promoting Principles

G. Hartmann,H. Wagner
Innate Immunity Resistance and Disease Promoting Principles Book PDF

Author : G. Hartmann,H. Wagner
Publisher : Karger Medical and Scientific Publishers
Page : 140 pages
File Size : 46,6 Mb
Release : 2013-06-05
Category : Science
ISBN : 9783318023473

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Innate Immunity: Resistance and Disease-Promoting Principles by G. Hartmann,H. Wagner Pdf

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Innate Immunity of Plants, Animals and Humans

Holger Heine
Innate Immunity of Plants Animals and Humans Book PDF

Author : Holger Heine
Publisher : Springer
Page : 266 pages
File Size : 53,8 Mb
Release : 2008
Category : Medical
ISBN : UOM:39015074253801

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Innate Immunity of Plants, Animals and Humans by Holger Heine Pdf

All living organisms are in a constant battle against their environment. Since uncontained microorganisms would simply overgrow all higher animals, the evolution of multicellular organisms required adequate and efficient defense mechanisms to protect their own integrity and to ensure their own survival. These defense mechanisms, encompassing receptor proteins that sense the presence of pathogens and effector molecules that are involved in controlling them, are the elemental parts of the innate immune system. For many species, the innate immune system is the sole active defense system. Long thought to be an unspecific immune response, the discovery of the Toll-like receptors and their ligands finally revealed just how specific the innate immune response actually is. This book wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.

Current Topics in Innate Immunity II

John D. Lambris,George Hajishengallis
Current Topics in Innate Immunity II Book PDF

Author : John D. Lambris,George Hajishengallis
Publisher : Springer
Page : 354 pages
File Size : 40,7 Mb
Release : 2013-10-25
Category : Medical
ISBN : 1461429528

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Current Topics in Innate Immunity II by John D. Lambris,George Hajishengallis Pdf

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.

Treating Infectious Diseases in a Microbial World

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Treating Infectious Diseases in a Microbial World Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 52,6 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689

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Treating Infectious Diseases in a Microbial World by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials Pdf

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Crossroads Between Innate and Adaptive Immunity V

Stephen P. Schoenberger,Peter D. Katsikis,Bali Pulendran
Crossroads Between Innate and Adaptive Immunity V Book PDF

Author : Stephen P. Schoenberger,Peter D. Katsikis,Bali Pulendran
Publisher : Springer
Page : 154 pages
File Size : 51,5 Mb
Release : 2016-10-22
Category : Medical
ISBN : 3319372289

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Crossroads Between Innate and Adaptive Immunity V by Stephen P. Schoenberger,Peter D. Katsikis,Bali Pulendran Pdf

This volume presents a collection of reviews derived from work presented at the Aegean Conference: “5th Crossroads Between Innate and Adaptive Immunity”. This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive Immunity, a necessary step in the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive Immunity, and maximized scientific interchange through lecture presentations, poster sessions and informal discussions.

Mouse Models of Innate Immunity

Irving Coy Allen
Mouse Models of Innate Immunity Book PDF

Author : Irving Coy Allen
Publisher : Unknown
Page : 225 pages
File Size : 45,5 Mb
Release : 2013
Category : Animal models in research
ISBN : 1627034811

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Mouse Models of Innate Immunity by Irving Coy Allen Pdf

The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.

The Science and Applications of Synthetic and Systems Biology

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
The Science and Applications of Synthetic and Systems Biology Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 54,7 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Toll-Like Receptors (TLRs) and Innate Immunity

Stefan Bauer,Gunther Hartmann
Toll Like Receptors TLRs and Innate Immunity Book PDF

Author : Stefan Bauer,Gunther Hartmann
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 47,8 Mb
Release : 2007-12-11
Category : Medical
ISBN : 9783540721673

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Toll-Like Receptors (TLRs) and Innate Immunity by Stefan Bauer,Gunther Hartmann Pdf

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Chimpanzees in Biomedical and Behavioral Research

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Chimpanzees in Biomedical and Behavioral Research Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 200 pages
File Size : 48,7 Mb
Release : 2012-01-05
Category : Science
ISBN : 9780309220392

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Chimpanzees in Biomedical and Behavioral Research by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research Pdf

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Human Cytomegalovirus

Thomas E. Shenk,Mark F. Stinski
Human Cytomegalovirus Book PDF

Author : Thomas E. Shenk,Mark F. Stinski
Publisher : Springer Science & Business Media
Page : 477 pages
File Size : 49,7 Mb
Release : 2008-05-09
Category : Medical
ISBN : 9783540773498

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Human Cytomegalovirus by Thomas E. Shenk,Mark F. Stinski Pdf

This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.