Mouse Models Of Innate Immunity

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Mouse Models of Innate Immunity

Irving C. Allen
Mouse Models of Innate Immunity Book PDF

Author : Irving C. Allen
Publisher : Humana Press
Page : 258 pages
File Size : 53,6 Mb
Release : 2019-02-24
Category : Medical
ISBN : 1493991663

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Mouse Models of Innate Immunity by Irving C. Allen Pdf

This second edition presents methods and protocols to aid readers in the design and execution of experiments used to define critical elements associated with innate immune system function. New and updated chapters detail protocols on in vitro and ex vivo studies in key cell types associated with innate immunity and with in vivo protocols used to study immune system function in the mouse. Additionally, chapters describe methods to evaluate innate immune function and new protocols associated with autism, cancer, microfluidics platforms, and CRISPR systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols, Second Edition will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune system.

Mouse Models of Innate Immunity

Irving C. Allen
Mouse Models of Innate Immunity Book PDF

Author : Irving C. Allen
Publisher : Humana
Page : 0 pages
File Size : 45,6 Mb
Release : 2016-08-27
Category : Medical
ISBN : 1493960369

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Mouse Models of Innate Immunity by Irving C. Allen Pdf

The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.

The Innate Immune Response to Noninfectious Stressors

Massimo Amadori
The Innate Immune Response to Noninfectious Stressors Book PDF

Author : Massimo Amadori
Publisher : Academic Press
Page : 276 pages
File Size : 50,9 Mb
Release : 2016-02-23
Category : Medical
ISBN : 9780128019740

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The Innate Immune Response to Noninfectious Stressors by Massimo Amadori Pdf

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Janeway's Immunobiology

Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Janeway s Immunobiology Book PDF

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 40,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Advances in Human Immune System (HIS) Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy

Yasuyuki Saito,Alexandre P. A. Theocharides,Tim Willinger
Advances in Human Immune System HIS Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy Book PDF

Author : Yasuyuki Saito,Alexandre P. A. Theocharides,Tim Willinger
Publisher : Frontiers Media SA
Page : 253 pages
File Size : 43,5 Mb
Release : 2022-02-10
Category : Medical
ISBN : 9782889743186

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Advances in Human Immune System (HIS) Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy by Yasuyuki Saito,Alexandre P. A. Theocharides,Tim Willinger Pdf

Topic Editor Prof. Aimin Xu receives financial support from Servier Laboratories. The other Topic Editors declare no competing interests with regards to the Research Topic theme.

Innate Immunity

Jonathan Ewbank,Eric Vivier
Innate Immunity Book PDF

Author : Jonathan Ewbank,Eric Vivier
Publisher : Springer Science & Business Media
Page : 466 pages
File Size : 50,7 Mb
Release : 2008
Category : Medical
ISBN : 9781588297464

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Innate Immunity by Jonathan Ewbank,Eric Vivier Pdf

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Lung Innate Immunity and Inflammation

Scott Alper,William J. Janssen
Lung Innate Immunity and Inflammation Book PDF

Author : Scott Alper,William J. Janssen
Publisher : Humana Press
Page : 433 pages
File Size : 51,8 Mb
Release : 2018-07-09
Category : Science
ISBN : 1493985698

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Lung Innate Immunity and Inflammation by Scott Alper,William J. Janssen Pdf

This detailed book explores methods to isolate, characterize, and investigate key lung innate immune cells. Beginning with an overview, the volume then continues with methods for creating in vitro and in vivo model systems to study inflammatory lung diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lung Innate Immunity and Inflammation: Methods and Protocols aims to be a guidebook and will be of value and interest to researchers investigating innate immunity and inflammation in the lung as well as other organs and tissues.

Innate Antiviral Immunity

Karen Mossman
Innate Antiviral Immunity Book PDF

Author : Karen Mossman
Publisher : Humana
Page : 0 pages
File Size : 41,6 Mb
Release : 2018-08-03
Category : Medical
ISBN : 1493984268

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Innate Antiviral Immunity by Karen Mossman Pdf

This book explores methods to study the complex and evolving interplay between a virus and its host that range from model systems to the detection of chemical molecules. The collection starts with the application of humanized mice and zebrafish as model organisms to study virus-host interactions and induction of innate immune responses. Subsequent chapters outline diverse methods to detect small interfering RNAs, microRNAs, and virus-derived dsRNA from a variety of cells, tissues, and organisms, as well as to interrogating the cytosolic RNA and DNA sensing pathways, including using RNA PAMPs as molecular tools, purification of cGAMP from virus particles and infected cells, and mechanisms to visualize the subcellular localization and activation of the adaptor proteins MAVS and STING. Cutting-edge methods, including high-throughput and genome-wide CRISPR/Cas9 screens, chromosome conformation capture, and whole-exome sequencing, are described to identify novel mediators, pathways, and variants underlying host susceptibility. Given the importance of studying these pathways and players under physiologic conditions, methods describing the isolation of primary mouse sensory neurons and group 2 innate lymphoid cells are also provided. Finally, this collection comes full circle back to the whole organism level and concludes with epidemiological methods to investigate virus-host interactions and the induction of innate immunity. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Innate Antiviral Immunity: Methods and Protocols spans a diverse array of approaches to study and elucidate the intricacies of this vital area of study. The chapter 'Morphological Separation of Clustered Nuclei in Histological Images' is published open access under a CC BY 4.0 license at link.springer.com.

Antibody Fc:

Margaret Ackerman,Falk Nimmerjahn
Antibody Fc Book PDF

Author : Margaret Ackerman,Falk Nimmerjahn
Publisher : Academic Press
Page : 358 pages
File Size : 50,7 Mb
Release : 2013-08-06
Category : Medical
ISBN : 9780123948182

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Antibody Fc: by Margaret Ackerman,Falk Nimmerjahn Pdf

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

MIF Family Cytokines in Innate Immunity and Homeostasis

Richard Bucala,Jürgen Bernhagen
MIF Family Cytokines in Innate Immunity and Homeostasis Book PDF

Author : Richard Bucala,Jürgen Bernhagen
Publisher : Springer
Page : 246 pages
File Size : 42,7 Mb
Release : 2017-06-12
Category : Science
ISBN : 9783319523545

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MIF Family Cytokines in Innate Immunity and Homeostasis by Richard Bucala,Jürgen Bernhagen Pdf

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

The Mouse in Biomedical Research

Anonim
The Mouse in Biomedical Research Book PDF

Author : Anonim
Publisher : Academic Press
Page : 392 pages
File Size : 47,6 Mb
Release : 2006-12-19
Category : Science
ISBN : 0123694582

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The Mouse in Biomedical Research by Anonim Pdf

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

The Laboratory Mouse

Peggy J. Danneman,Mark A. Suckow,Cory Brayton
The Laboratory Mouse Book PDF

Author : Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publisher : CRC Press
Page : 247 pages
File Size : 42,8 Mb
Release : 2012-09-25
Category : Medical
ISBN : 9781439854228

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The Laboratory Mouse by Peggy J. Danneman,Mark A. Suckow,Cory Brayton Pdf

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a

Toll-Like Receptors (TLRs) and Innate Immunity

Stefan Bauer,Gunther Hartmann
Toll Like Receptors TLRs and Innate Immunity Book PDF

Author : Stefan Bauer,Gunther Hartmann
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 51,9 Mb
Release : 2007-12-11
Category : Medical
ISBN : 9783540721673

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Toll-Like Receptors (TLRs) and Innate Immunity by Stefan Bauer,Gunther Hartmann Pdf

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Lung Innate Immunity and Inflammation

Scott Alper,William J. Janssen
Lung Innate Immunity and Inflammation Book PDF

Author : Scott Alper,William J. Janssen
Publisher : Humana
Page : 433 pages
File Size : 54,6 Mb
Release : 2019-07-23
Category : Science
ISBN : 1493993291

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Lung Innate Immunity and Inflammation by Scott Alper,William J. Janssen Pdf

This detailed book explores methods to isolate, characterize, and investigate key lung innate immune cells. Beginning with an overview, the volume then continues with methods for creating in vitro and in vivo model systems to study inflammatory lung diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lung Innate Immunity and Inflammation: Methods and Protocols aims to be a guidebook and will be of value and interest to researchers investigating innate immunity and inflammation in the lung as well as other organs and tissues.

Innate Immunity in Health and Disease

Shailendra K. Saxena,Hridayesh Prakash
Innate Immunity in Health and Disease Book PDF

Author : Shailendra K. Saxena,Hridayesh Prakash
Publisher : BoD – Books on Demand
Page : 416 pages
File Size : 52,8 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9781838807658

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Innate Immunity in Health and Disease by Shailendra K. Saxena,Hridayesh Prakash Pdf

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.