Tumor Angiogenesis

Author : Sophia Ran
Publisher : BoD – Books on Demand
Page : 310 pages
File Size : 51,8 Mb
Release : 2012-02-17
Category : Medical
ISBN : 9789535100096

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Tumor Angiogenesis by Sophia Ran Pdf

Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.

Author : Domenico Ribatti
Publisher : Springer Science & Business Media
Page : 126 pages
File Size : 55,7 Mb
Release : 2008-12-16
Category : Medical
ISBN : 9781402095634

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History of Research on Tumor Angiogenesis by Domenico Ribatti Pdf

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

Author : Dieter Marmé,Norbert Fusenig
Publisher : Springer Science & Business Media
Page : 845 pages
File Size : 54,5 Mb
Release : 2007-12-05
Category : Medical
ISBN : 9783540331773

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Tumor Angiogenesis by Dieter Marmé,Norbert Fusenig Pdf

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Author : Ruben R. Gonzalez-Perez,Bo R. Rueda
Publisher : CRC Press
Page : 462 pages
File Size : 43,6 Mb
Release : 2013-05-09
Category : Medical
ISBN : 9781466580985

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Tumor Angiogenesis Regulators by Ruben R. Gonzalez-Perez,Bo R. Rueda Pdf

The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and other metabolic disorders can influence the development and growth of cancer. It is of significant interest not only to oncologists but also to a wide range of medical practitioners and researchers.

Author : Francis S. Markland,Stephen Swenson,Radu Minea
Publisher : John Wiley & Sons
Page : 353 pages
File Size : 50,8 Mb
Release : 2010-06-08
Category : Science
ISBN : 9783527320912

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Tumor Angiogenesis by Francis S. Markland,Stephen Swenson,Radu Minea Pdf

Themen dieses Bandes sind die molekularen Mechanismen der Tumor-Angiogenese, die Suche nach einschlägigen Targets für die Wirkstoffforschung und die Entwicklung von Kombinationstherapien mit bereits existierenden Ansätzen. Die ideale Informationsquelle für Studenten, Ärzte und Forscher in der Pharmaindustrie!

Author : Domenico Ribatti,Francesco Pezzella
Publisher : Academic Press
Page : 198 pages
File Size : 51,5 Mb
Release : 2020-01-21
Category : Science
ISBN : 9780128194942

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Tumor Vascularization by Domenico Ribatti,Francesco Pezzella Pdf

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Author : William D. Figg,Judah Folkman
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 42,9 Mb
Release : 2008-05-24
Category : Medical
ISBN : 9780387715186

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Angiogenesis by William D. Figg,Judah Folkman Pdf

Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

Author : Matthias Kirsch,Peter McL. Black
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 40,7 Mb
Release : 2004-02-29
Category : Medical
ISBN : 1402077041

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Angiogenesis in Brain Tumors by Matthias Kirsch,Peter McL. Black Pdf

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field

Author : Shaker Mousa,Paul Davis
Publisher : Academic Press
Page : 210 pages
File Size : 42,8 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9780128026731

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Anti-Angiogenesis Strategies in Cancer Therapies by Shaker Mousa,Paul Davis Pdf

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 42,9 Mb
Release : 2012
Category : Electronic
ISBN : 9535167952

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Tumor Angiogenesis by Anonim Pdf

Author : Domenico Ribatti
Publisher : Springer Nature
Page : 216 pages
File Size : 55,7 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9781071627037

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Tumor Angiogenesis Assays by Domenico Ribatti Pdf

This second edition provides new and updated methods and protocols for studying tumor angiogenesis in vitro and in vivo. Chapters detail morphological aspects of tumor angiogenesis, aortic ring, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Tumor Angiogenesis Assays: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about this important and developing field.

Author : Hans-Inge Peterson
Publisher : CRC Press
Page : 320 pages
File Size : 41,9 Mb
Release : 2020-04-15
Category : Medical
ISBN : 9781000083552

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Tumor Blood Circulation by Hans-Inge Peterson Pdf

First Published in 1979, this book offers a full, insight into the relationship between malignant tumors and blood flow. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Author : I.D. Goldberg,E.R. Rosen
Publisher : Birkhäuser
Page : 437 pages
File Size : 42,8 Mb
Release : 2013-03-12
Category : Science
ISBN : 9783034890069

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Regulation of Angiogenesis by I.D. Goldberg,E.R. Rosen Pdf

We now know that excessive angiogenesis contributes to the development of a variety of disease processes, including cancer, chronic inflammatory disease, and diabetic retinopathy. On the other hand, insufficient angiogenesis may impair wound healing and organ repair. This volume describes recent advances in understanding the molecular regulation of angiogenesis. Subjects covered include important pro-angiogenic growth factors (e.g., vascular endothelial growth factor/vascular permeability factor, scatter factor/hepatocyte growth factor) and their receptors; angiogenesis inhibitors (e.g., thrombospondin-1, angiostatin); extracellular matrix factors (e.g., laminin) and specific vascular integrins (avb3 and avb5) that regulate angiogenesis; the roles of fibrin and the fibrinolytic system in angiogenesis; physical factors that regulate angiogenesis (hypoxia, pH); mechanisms by which specific cell types (macrophages, pericytes) regulate angiogenesis; and lymphangiogenesis, a subject often ignored in volumes of this type. Several chapters are also devoted to the prognostic and therapeutic implications of tumor angiogenesis, a subject of great interest to clinicians. Reflecting the latest advances in this exciting and expanding field, this comprehensive and authoritative monograph will prove invaluable to cell biologists, cancer researchers and pharmacologists.

Author : Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Publisher : Springer
Page : 505 pages
File Size : 48,5 Mb
Release : 2014-05-27
Category : Science
ISBN : 9782817804668

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Molecular Mechanisms of Angiogenesis by Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin Pdf

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Author : Domenico Ribatti
Publisher : Academic Press
Page : 112 pages
File Size : 51,6 Mb
Release : 2017-08-18
Category : Science
ISBN : 9780128140215

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In Vivo Models to Study Angiogenesis by Domenico Ribatti Pdf

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant