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Author : VijayaKumar Sukumaran,Venkatesh Sundararajan
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 41,5 Mb
Release : 2022-08-03
Category : Medical
ISBN : 9782889764976
Author : Belma Turan,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 47,7 Mb
Release : 2014-01-08
Category : Science
ISBN : 9781461493174
Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.
Author : Lu Cai,Ying Xin,Jamie Lynn Young,Rajesh Mohanraj
Publisher : Frontiers Media SA
Page : 127 pages
File Size : 52,9 Mb
Release : 2022-11-14
Category : Medical
ISBN : 9782832505410
Author : Wilbert S. Aronow,Takashi Murashita
Publisher : BoD – Books on Demand
Page : 187 pages
File Size : 41,9 Mb
Release : 2019-12-18
Category : Medical
ISBN : 9781789852752
Inflammatory Heart Diseases presents comprehensive information on pericardial diseases, cardiomyopathies, and atherosclerotic cardiovascular diseases. Chapters are written by experts in the field and cover such topics as advanced concepts in pericardial disease, pericardial disease in the elderly, inflammation and diabetic cardiomyopathy, medical imaging in myocarditis, and the role of lifestyle in development of coronary heart disease, among others.
Author : Gianfranco Sinagra,Marco Merlo,Bruno Pinamonti
Publisher : Springer
Page : 241 pages
File Size : 52,8 Mb
Release : 2019-05-17
Category : Medical
ISBN : 9783030138646
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Author : Hao Zhou,Rui Guo,Amanda Lochner,Russel J. Reiter,Hsueh-Hsiao Wang
Publisher : Frontiers Media SA
Page : 199 pages
File Size : 48,6 Mb
Release : 2022-11-01
Category : Science
ISBN : 9782832505540
The heart is a strong muscular pump that enables tissue and organ perfusion. Therefore, a continuous supply of fresh blood is vital for cardiac function. In coronary artery disease, plaques or thrombi induce rapid occlusion, which restricts blood flow to the heart. The primary effect of coronary artery disease is substantial cardiomyocyte death, which prevents the heart from effectively pumping blood to vital organs.
Author : Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 53,6 Mb
Release : 2021-03-04
Category : Medical
ISBN : 9782889665563
Author : Lu Cai,Ying Xin,Jamie Lynn Young,Rajesh Mohanraj
Publisher : Frontiers Media SA
Page : 127 pages
File Size : 50,8 Mb
Release : 2024-02-20
Category : Medical
ISBN : 9782832545119
Author : Kaan Kırali
Publisher : BoD – Books on Demand
Page : 472 pages
File Size : 54,8 Mb
Release : 2017-04-12
Category : Medical
ISBN : 9789535130390
Cardiomyopathies are the most featured cardiac pathologies in the twenty-first century, that threaten public health and burden healthcare budgets. This book is composed of the main topics on pathophysiology, general forms and specific types of cardiomyopathies and it also introduces new research in the field. Specific forms with or without genetic inheritance are discussed separately to attract the readers' attention on these topics. Well-known medical follow-up strategies occur ineffective at the end-stage heart failure, however, new surgical approaches can be an alternative for these patients to get a chance at the last crossroad and to improve their life quality and survival and also to gain or prolong time until possible heart transplantation.
Author : H. Böhles,A. C. Sewell
Publisher : CRC Press
Page : 188 pages
File Size : 55,8 Mb
Release : 2004
Category : Cardiomyopathy
ISBN : 3887631048
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
Author : Xiaoqiang Tang,Md. Shenuarin Bhuiyan,InKyeom Kim
Publisher : Frontiers Media SA
Page : 219 pages
File Size : 43,6 Mb
Release : 2021-12-06
Category : Science
ISBN : 9782889718139
Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publisher : Springer
Page : 154 pages
File Size : 54,6 Mb
Release : 2018-05-12
Category : Science
ISBN : 9783319744704
This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Author : Celestino Sardu,Claudio de Lucia,Laurent Metzinger,Coert J. Zuurbier
Publisher : Frontiers Media SA
Page : 122 pages
File Size : 48,9 Mb
Release : 2019-05-15
Category : Electronic
ISBN : 9782889458516
Author : Junjie Xiao,Sanda Cretoiu
Publisher : Springer
Page : 307 pages
File Size : 42,7 Mb
Release : 2017-09-19
Category : Science
ISBN : 9789811043970
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
Author : Peter P. Toth,Vasudevan A. Raghavan
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 47,5 Mb
Release : 2012-10-14
Category : Medical
ISBN : 9781455747115
Chronic overconsumption of sugar and fat elevates plasma levels of insulin and free fatty acids, a process referred to as glucolipotoxicity. This phenomenon may lead to heart failure. This issue explores in depth the relationship between glucolipotoxicity and heart failure.