Vaccine Adjuvants And Delivery Systems

Vaccine Adjuvants And Delivery Systems Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Vaccine Adjuvants And Delivery Systems book. This book definitely worth reading, it is an incredibly well-written.

Vaccine Adjuvants and Delivery Systems

Manmohan Singh
Vaccine Adjuvants and Delivery Systems Book PDF

Author : Manmohan Singh
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 49,8 Mb
Release : 2007-08-03
Category : Science
ISBN : 9780470134924

Get Book

Vaccine Adjuvants and Delivery Systems by Manmohan Singh Pdf

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

Manmohan Singh
Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines Book PDF

Author : Manmohan Singh
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 42,9 Mb
Release : 2013-03-03
Category : Medical
ISBN : 9781461453802

Get Book

Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines by Manmohan Singh Pdf

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Immunization

Ning Wang,Ting Wang
Immunization Book PDF

Author : Ning Wang,Ting Wang
Publisher : BoD – Books on Demand
Page : 124 pages
File Size : 55,5 Mb
Release : 2018-11-28
Category : Medical
ISBN : 9781789845389

Get Book

Immunization by Ning Wang,Ting Wang Pdf

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Darren R. Flower,Yvonne Perrie
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Book PDF

Author : Darren R. Flower,Yvonne Perrie
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 40,9 Mb
Release : 2012-12-09
Category : Medical
ISBN : 9781461450702

Get Book

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines by Darren R. Flower,Yvonne Perrie Pdf

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Subunit Vaccine Delivery

Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook
Subunit Vaccine Delivery Book PDF

Author : Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook
Publisher : Springer
Page : 433 pages
File Size : 54,5 Mb
Release : 2014-11-22
Category : Medical
ISBN : 9781493914173

Get Book

Subunit Vaccine Delivery by Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook Pdf

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Veterinary Vaccinology

Paul-Pierre Pastoret
Veterinary Vaccinology Book PDF

Author : Paul-Pierre Pastoret
Publisher : Elsevier Science & Technology
Page : 0 pages
File Size : 40,8 Mb
Release : 1997
Category : Animaux
ISBN : 0444819681

Get Book

Veterinary Vaccinology by Paul-Pierre Pastoret Pdf

Hardbound. Vaccination is widely recognised as one of the most efficient tools in public health, showing obvious cost-benefit advantages for all target populations involved.Vaccines in the veterinary field can contribute greatly to the welfare of domestic and wild animals and, indirectly, to environmental protection. The aim of animal vaccination will increasingly be to prevent dissemination of zoonoses (such as rabies, taeniosis, salmonellosis, etc.) rather than to protect the animal itself, especially when infection or infestation is not harmful to the reservoir (cysticercosis)At present there is insufficient overall understanding of some important aspects of veterinary vaccines. Literature on the subject exists, but often consists of either research communications or 'catalogue-type' descriptive works. This unique book fills a gap within the already available literature. The scope is broad and covers all aspects of vaccines and vaccination in the

Vaccine Design

Jessica R. Burdman
Vaccine Design Book PDF

Author : Jessica R. Burdman
Publisher : Plenum Publishing Corporation
Page : 1008 pages
File Size : 55,7 Mb
Release : 1995
Category : Drugs
ISBN : UOM:39015034444953

Get Book

Vaccine Design by Jessica R. Burdman Pdf

Immunological and formulation design considerations for subunit vaccines. Public health implications of emerging vaccine technologies. Preclinical safety assessment considerations in vaccine development. Regulatory considerations in vaccine design. Clinical considerations in vaccine trials with special reference to candidate HIV vaccines. Laboratory empiricism, clinical design, and social value: the rough road toward vaccine development. A compedium of vaccine adjuvants and excipients. Adjuvant properties of aluminum and calcium compounds. Structure and properties of aluminum-containing adjuvants. MF59: design and evaluation of a safe and potent adjuvant for human vaccines. Development of vaccines based on formulations containing nonionic block copolymers. Development of an emulsion-based muramyl dipeptide adjuvant formulation for vaccines. Liposomal presentation of antigens for human vaccines. Liposome design and vaccine development. Lipid matrix-based vaccines for mucosal and systemic immunization. Polymer microspheres for vaccine delivery. Vehicle for oral immunization. Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems. Nanoparticles as adjuvants for vaccines. Water-soluble phosphazene polymers for parenteral and mucosal vaccine delivery. Monophosphoryl lipid A as an adjuvant: past experiences and new directions. Structural and immunological characterization of the vaccine adjuvant QS-21. A novel generation of viral vaccines based on the ISCOM matrix. Vaccine adjuvants based on gamma inulin. A new approach to vaccine adjuvants: immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine. Stearyl tyrosine: an organic equivalent of aluminum-based immunoadjuvants. Cytokines as vaccine adjuvants: current status and potential applications. Cytokines as immunological adjuvants. Cytokine-containing liposomes as adjuvants for subunit vaccines. Haemophilus influenzae type b conjugate vaccines. Pneumococcal conjugate vaccines. Lyme vaccine enhancement: N-terminal acylation of a protein antigen and inclusion of a saponin adjuvant. Vaccine research and development for the prevention of filarial nematode infections. Retrovirus and retrotransposon particles as antigen presentation and delivery systems. Rationale and approaches to constructing preerythrocytic malaria vaccines. The MAP system: a flexible and unambiguous vaccine design of branched peptides. Design of experimental synthetic peptide immunogens for prevention of HIV-1 and HTLV-I retroviral infections. Design and testing of peptide-based cytotoxic T-cell-mediated immunotherapeutics to treat infectious diseases and cancer. Development of active specific immunotherapeutic agents based on cancer-associated mucins. Synthetic peptide vaccines for schistosomiasis. Synthetic hormone/growth factor subunit vaccine with application to antifertility and cancer.

Immunopotentiators in Modern Vaccines

Virgil Schijns,Derek O'Hagan
Immunopotentiators in Modern Vaccines Book PDF

Author : Virgil Schijns,Derek O'Hagan
Publisher : Academic Press
Page : 508 pages
File Size : 41,9 Mb
Release : 2016-11-02
Category : Science
ISBN : 9780128040959

Get Book

Immunopotentiators in Modern Vaccines by Virgil Schijns,Derek O'Hagan Pdf

Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

Practical Aspects of Vaccine Development

Parag Kolhe,Satoshi Ohtake
Practical Aspects of Vaccine Development Book PDF

Author : Parag Kolhe,Satoshi Ohtake
Publisher : Elsevier
Page : 386 pages
File Size : 54,5 Mb
Release : 2021-09-08
Category : Business & Economics
ISBN : 9780128143575

Get Book

Practical Aspects of Vaccine Development by Parag Kolhe,Satoshi Ohtake Pdf

Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Mucosal Vaccines

Hiroshi Kiyono
Mucosal Vaccines Book PDF

Author : Hiroshi Kiyono
Publisher : Elsevier
Page : 501 pages
File Size : 53,9 Mb
Release : 1996-10-23
Category : Medical
ISBN : 9780080537054

Get Book

Mucosal Vaccines by Hiroshi Kiyono Pdf

This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

Polymers in Nanomedicine

Shigeru Kunugi,Tetsuji Yamaoka
Polymers in Nanomedicine Book PDF

Author : Shigeru Kunugi,Tetsuji Yamaoka
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 43,9 Mb
Release : 2012-02-02
Category : Technology & Engineering
ISBN : 9783642278556

Get Book

Polymers in Nanomedicine by Shigeru Kunugi,Tetsuji Yamaoka Pdf

Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery, by Ernst Wagner Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine, by Takami Akagi, Masanori Baba and Mitsuru Akashi Biodegradable Polymeric Assemblies for Biomedical Materials, by Yuichi Ohya, Akihiro Takahashi and Koji Nagahama PEGylation Technology in Nanomedicine, by Yutaka Ikeda and Yukio Nagasaki Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions, by Kazuhiko Ishihara, Yan Xu and Tomohiro Konno Design of Biointerfaces for Regenerative Medicine, by Yusuke Arima, Koichi Kato, Yuji Teramura and Hiroo Iwata Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration, by Jeremy J. Mercuri and Dan T. Simionescu Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics, by Ranu K. Dutta, Prashant K. Sharma, Hisatoshi Kobayashi and Avinash C. Pandey

Vaccine Adjuvants

Derek T. O’Hagan
Vaccine Adjuvants Book PDF

Author : Derek T. O’Hagan
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 43,9 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592590834

Get Book

Vaccine Adjuvants by Derek T. O’Hagan Pdf

Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.

Immunization - Vaccine Adjuvant Delivery System and Strategies

Ning Wang
Immunization Vaccine Adjuvant Delivery System and Strategies Book PDF

Author : Ning Wang
Publisher : Unknown
Page : 122 pages
File Size : 52,5 Mb
Release : 2018
Category : Public aspects of medicine
ISBN : 1789845394

Get Book

Immunization - Vaccine Adjuvant Delivery System and Strategies by Ning Wang Pdf

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Inflammation, 4 Volume Set

Jean-Marc Cavaillon,Mervyn Singer
Inflammation 4 Volume Set Book PDF

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 48,7 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

Get Book

Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Micro- and Nanotechnology in Vaccine Development

Mariusz Skwarczynski,Istvan Toth
Micro and Nanotechnology in Vaccine Development Book PDF

Author : Mariusz Skwarczynski,Istvan Toth
Publisher : William Andrew
Page : 460 pages
File Size : 48,7 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9780323400299

Get Book

Micro- and Nanotechnology in Vaccine Development by Mariusz Skwarczynski,Istvan Toth Pdf

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines