Vcd Spectroscopy For Organic Chemists

Author : Philip J. Stephens,Frank J. Devlin,James R. Cheeseman
Publisher : CRC Press
Page : 388 pages
File Size : 44,5 Mb
Release : 2012-06-25
Category : Science
ISBN : 9781439821718

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VCD Spectroscopy for Organic Chemists by Philip J. Stephens,Frank J. Devlin,James R. Cheeseman Pdf

Stimulated by the increasing importance of chiral molecules as pharmaceuticals and the need for enantiomerically pure drugs, techniques in chiral chemistry have been expanded and refined, especially in the areas of chromatography, asymmetric synthesis, and spectroscopic methods for chiral molecule structural characterization. In addition to synthetic chiral molecules, naturally occurring molecules, which are invariably chiral and generally enantiomerically enriched, are of potential interest as leads for new drugs. VCD Spectroscopy for Organic Chemists discusses the applications of vibrational circular dichroism (VCD) spectroscopy to the structural characterization of chiral organic molecules. The book provides all of the information about VCD spectroscopy that an organic chemist needs in order to make use of the technique. The authors, experts responsible for much of the existing literature in this field, discuss the experimental measurement of VCD and the theoretical prediction of VCD. In addition, they evaluate the advantages and limitations of the technique in determining molecular structure. Given the availability of commercial VCD instrumentation and quantum chemistry software, it became possible in the late 1990s for chemists to use VCD in elucidating the stereochemistries of chiral organic molecules. This book helps organic chemists become more aware of the utility of VCD spectroscopy and provides them with sufficient knowledge to incorporate the technique into their own research.

Author : James W. Cooper
Publisher : Unknown
Page : 408 pages
File Size : 41,6 Mb
Release : 1980-05-02
Category : Science
ISBN : UOM:39015016061189

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Spectroscopic Techniques for Organic Chemists by James W. Cooper Pdf

"Spectroscopy has become the organic chemist's most important tool in identifying compounds and studying their interactions. The arsenal of techniques available to the research chemist has, over the years, expanded from the familiar infrared, proton nmr and mass spectroscopy, to include the routine use of carbon-13 nmr spectroscopy and such modern methods of data acquisition as Fourier transform nmr, laser Raman spectroscopy, and UV spectroscopy. This book serves as an introduction to all of the major spectroscopic techniques, using over 200 actual spectra as examples, and providing a substantial number of problems and completely worked-through solutions that demonstrate how spectral techniques are applied to analytical problems. The book represents a significant departure from the scope of general spectroscopy texts. In addition to the usual chapters on infrared, proton nmr and mass spectroscopy, a number of increasingly important techniques have been included for the first time. Chapter 4, for instance, introduces not only the analysis of proton nmr spectra, but also describes iteration of theoretical nmr spectra for a best fit with observed experimental spectra using the popular LAOCOON III program. A complete FORTRAN listing for a conversational pendix I. Chapter 5 presents a non-mathematical description of Fourier transform nmr, including signal averaging, decoupling methods, quadrature detection, and the Fourier transform itself, and Chapter 6 goes on to describe Fourier transform techniques in carbon-13 spectroscopy. Chapter 7 introduces simple Huckel M.O. theory and the SHMO program for calculating the resonance stabilization of various systems, material which lays the groundwork for Chapter 8's discussion of ultraviolet spectroscopy using examples of ways in which energies can be correlated with SHMO parameters. A SHMO timesharing conversational program is listed in Appendix II. Finally, Chapter 10 outlines the organic chemical applications of laser Raman spectroscopy and the functional groups most easily identified using this method. Both organic chemists and graduate and advanced undergraduate students will find in the book's breadth of coverage an ideal introduction to the identification of organic compounds by spectroscopic means."- Publisher.

Author : S. A. Richards,J. C. Hollerton
Publisher : John Wiley & Sons
Page : 345 pages
File Size : 44,5 Mb
Release : 2010-12-07
Category : Science
ISBN : 9780470977224

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Essential Practical NMR for Organic Chemistry by S. A. Richards,J. C. Hollerton Pdf

This book describes the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation. It features a significant amount of vital chemical shift and coupling information but more importantly, it presents sound principles for the selection of the techniques relevant to the solving of particular types of problem, whilst stressing the importance of extracting the maximum available information from the simple 1-D proton experiment and of using this to plan subsequent experiments. Proton NMR is covered in detail, with a description of the fundamentals of the technique, the instrumentation and the data that it provides before going on to discuss optimal solvent selection and sample preparation. This is followed by a detailed study of each of the important classes of protons, breaking the spectrum up into regions (exchangeables, aromatics, heterocyclics, alkenes etc.). This is followed by consideration of the phenomena that we know can leave chemists struggling; chiral centres, restricted rotation, anisotropy, accidental equivalence, non-first-order spectra etc. Having explained the potential pitfalls that await the unwary, the book then goes on to devote chapters to the chemical techniques and the most useful instrumental ones that can be employed to combat them. A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.

Author : Maria-Magdalena Cid,Jorge Bravo
Publisher : John Wiley & Sons
Page : 554 pages
File Size : 40,8 Mb
Release : 2015-04-20
Category : Science
ISBN : 9783527333363

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Structure Elucidation in Organic Chemistry by Maria-Magdalena Cid,Jorge Bravo Pdf

Intended for advanced readers, this is a review of all relevant techniques for structure analysis in one handy volume. As such, it provides the latest knowledge on spectroscopic and related techniques for chemical structure analysis, such as NMR, optical spectroscopy, mass spectrometry and X-ray crystallography, including the scope and limitation of each method. As a result, readers not only become acquainted with the techniques, but also the advantages of the synergy between them. This enables them to choose the correct analytical method for each problem, saving both time and resources. Special emphasis is placed on NMR and its application to absolute configuration determination and the analysis of molecular interactions. Adopting a practical point of view, the author team from academia and industry guarantees both solid methodology and applications essential for structure determination, equipping experts as well as newcomers with the tools to solve any structural problem.

Author : David W. Boykin
Publisher : CRC Press
Page : 332 pages
File Size : 42,5 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781000103090

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17 0 NMR Spectroscopy in Organic Chemistry by David W. Boykin Pdf

This book provides a comprehensive review of the application of 17O NMR spectroscopy to organic chemistry. Topics include the theoretical aspects of chemical shift, quadrupolar and J coupling; 17O enrichment; the effect of steric interactions on 17O chemical shifts of functional groups in flexible and rigid systems; the application of 17O NMR spectroscopy to hydrogen bonding investigations; mechanistic problems in organic and bioorganic chemistry; and 17O NMR spectroscopy of oxygen monocoordinated to carbon in alcohols, ethers, and derivatives. Recent results that show correlations between molecular geometry, determined by X-ray studies and estimated by molecular mechanics calculations, and 17O chemical shifts are also covered. 17O Spectroscopy in Organic Chemistry provides important reference information for organic chemists and other scientists interested in 17O NMR spectroscopy as a tool for obtaining new structural and chemical data about organic molecules.

Author : Nina Berova,Koji Nakanishi,Robert W. Woody
Publisher : John Wiley & Sons
Page : 916 pages
File Size : 52,5 Mb
Release : 2000-05-03
Category : Science
ISBN : 0471330035

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Circular Dichroism by Nina Berova,Koji Nakanishi,Robert W. Woody Pdf

Unter Zirkulardichroismus (CD) versteht man die spezifisch unterschiedliche Absorption von links- und rechtszirkular polarisiertem Licht durch bestimmte Moleküle. CD-Effekte lassen sich in Abhängigkeit von der Wellenlänge messen und spektroskopisch auswerten. Dieser Band erläutert Theorie und Anwendung der CD-Spektroskopie insbesondere für Biomoleküle. Ausführlich behandelt werden Anwendungen auf den Gebieten der organischen Stereochemie und der Biopolymere. Geschrieben von anerkannten Spezialisten! (06/00)

Author : Ian Fleming,Dudley H. Williams
Publisher : Unknown
Page : 128 pages
File Size : 49,7 Mb
Release : 2019
Category : Organic compounds
ISBN : 3030182533

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Spectroscopic Methods in Organic Chemistry by Ian Fleming,Dudley H. Williams Pdf

This book is a well-established guide to the interpretation of the mass, ultraviolet, infrared and nuclear magnetic resonance spectra of organic compounds. It is designed for students of organic chemistry taking a course in the application of these techniques to structure determination. The text also remains useful as a source of data for organic chemists to keep on their desks throughout their career. In the seventh edition, substantial portions of the text have been revised reflecting knowledge gained during the author's teaching experience over the last seven years. The chapter on NMR has been divided into two separate chapters covering the 1D and 2D experiments. The discussion is also expanded to include accounts of the physics at a relatively simple level, following the development of the magnetization vectors as each pulse sequence is introduced. The emphasis on the uses of NMR spectroscopy in structure determination is retained. Worked examples and problem sets are included on a chapter level to allow students to practise their skills by determining the chemical structures of unknown compounds.

Author : Laurence A. Nafie
Publisher : John Wiley & Sons
Page : 373 pages
File Size : 51,8 Mb
Release : 2011-07-12
Category : Science
ISBN : 9781119977537

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Vibrational Optical Activity by Laurence A. Nafie Pdf

This unique book stands as the only comprehensive introduction to vibrational optical activity (VOA) and is the first single book that serves as a complete reference for this relatively new, but increasingly important area of molecular spectroscopy. Key features: A single-source reference on this topic that introduces, describes the background and foundation of this area of spectroscopy. Serves as a guide on how to use it to carry out applications with relevant problem solving. Depth and breadth of the subject is presented in a logical, complete and progressive fashion. Although intended as an introductory text, this book provides in depth coverage of this topic relevant to both students and professionals by taking the reader from basic theory through to practical and instrumental approaches.

Author : A. D. Kinghorn,H. Falk,J. Kobayashi
Publisher : Springer
Page : 602 pages
File Size : 53,9 Mb
Release : 2014-11-17
Category : Science
ISBN : 9783319052755

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Progress in the Chemistry of Organic Natural Products 100 by A. D. Kinghorn,H. Falk,J. Kobayashi Pdf

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Author : Ian Fleming,Dudley Williams
Publisher : Springer Nature
Page : 438 pages
File Size : 48,5 Mb
Release : 2020-01-17
Category : Science
ISBN : 9783030182526

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Spectroscopic Methods in Organic Chemistry by Ian Fleming,Dudley Williams Pdf

This book is a well-established guide to the interpretation of the mass, ultraviolet, infrared and nuclear magnetic resonance spectra of organic compounds. It is designed for students of organic chemistry taking a course in the application of these techniques to structure determination. The text also remains useful as a source of data for organic chemists to keep on their desks throughout their career. In the seventh edition, substantial portions of the text have been revised reflecting knowledge gained during the author's teaching experience over the last seven years. The chapter on NMR has been divided into two separate chapters covering the 1D and 2D experiments. The discussion is also expanded to include accounts of the physics at a relatively simple level, following the development of the magnetization vectors as each pulse sequence is introduced. The emphasis on the uses of NMR spectroscopy in structure determination is retained. Worked examples and problem sets are included on a chapter level to allow students to practise their skills by determining the chemical structures of unknown compounds.

Author : Darcy C. Burns,William F. Reynolds
Publisher : Royal Society of Chemistry
Page : 238 pages
File Size : 48,5 Mb
Release : 2018-09-26
Category : Science
ISBN : 9781782625391

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Optimizing NMR Methods for Structure Elucidation by Darcy C. Burns,William F. Reynolds Pdf

This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the minimum possible time. It covers the latest pulse sequences, acquisition and processing methods, practical areas not covered in most texts e.g. detailed consideration of the relative advantages and disadvantages of different pulse sequences, choosing acquisition and processing parameters to get the best possible data in the least possible time, pitfalls to avoid and how to minimize the risks of getting wrong structures. Useful in industrial, pharma or research environments, this reference book is for anyone involved with organic chemistry research and, in particular, natural products research requiring advice for getting the best results from the NMR facilities.

Author : Nina Berova,Prasad L. Polavarapu,Koji Nakanishi,Robert W. Woody
Publisher : John Wiley & Sons
Page : 884 pages
File Size : 42,8 Mb
Release : 2012-03-27
Category : Science
ISBN : 9781118012925

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Comprehensive Chiroptical Spectroscopy, Volume 2 by Nina Berova,Prasad L. Polavarapu,Koji Nakanishi,Robert W. Woody Pdf

This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.

Author : Caio Lima Firme
Publisher : CRC Press
Page : 438 pages
File Size : 43,8 Mb
Release : 2019-08-28
Category : Science
ISBN : 9781351205788

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Introductory Organic Chemistry and Hydrocarbons by Caio Lima Firme Pdf

A novel proposal for teaching organic chemistry based on a broader and simplified use of quantum chemistry theories and notions of some statistical thermodynamic concepts aiming to enrich the learning process of the organic molecular properties and organic reactions. A detailed physical chemistry approach to teach organic chemistry for undergraduate students is the main aim of this book. A secondary objective is to familiarize undergraduate students with computational chemistry since most of illustrations of optimized geometries (plus some topological graphs) and information is from quantum chemistry outputs which will also enable students to obtain a deeper understanding of organic chemistry.

Author : L. D. Field,S. Sternhell,John R. Kalman
Publisher : Unknown
Page : 304 pages
File Size : 40,9 Mb
Release : 1995-12-26
Category : Science
ISBN : STANFORD:36105018313846

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Organic Structures from Spectra by L. D. Field,S. Sternhell,John R. Kalman Pdf

Offers a realistic approach to solving problems used by organic chemists. Covering all the major spectroscopic techniques, it provides a graded set of problems that develop and consolidate students' understanding of organic spectroscopy. This edition contains more elementary problems and a modern approach to NMR spectra.

Author : George C. Levy,Gordon L. Nelson
Publisher : Unknown
Page : 248 pages
File Size : 52,5 Mb
Release : 1972
Category : Science
ISBN : UCSD:31822013898457

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Carbon-13 Nuclear Magnetic Resonance for Organic Chemists by George C. Levy,Gordon L. Nelson Pdf