Venoms To Drugs

Author : Glenn F. King
Publisher : Royal Society of Chemistry
Page : 320 pages
File Size : 46,7 Mb
Release : 2015-01-27
Category : Science
ISBN : 9781782624370

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Venoms to Drugs by Glenn F. King Pdf

The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Author : P. Gopalakrishnakone,Gerardo A. Corzo,Elia Diego-Garcia,Maria Elena Lima
Publisher : Springer
Page : 0 pages
File Size : 45,7 Mb
Release : 2016-05-10
Category : Medical
ISBN : 9400763883

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Spider Venoms by P. Gopalakrishnakone,Gerardo A. Corzo,Elia Diego-Garcia,Maria Elena Lima Pdf

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Author : Jean-Marc Sabatier,Zhijian Cao,Jing-Lin Wang,Patrick Michael McNutt,Yuri N. Utkin,Herve Kovacic,Delavar Shahbazzadeh,Heike Wulff
Publisher : Frontiers Media SA
Page : 252 pages
File Size : 50,5 Mb
Release : 2021-07-09
Category : Science
ISBN : 9782889669912

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Venoms, Animal and Microbial Toxins by Jean-Marc Sabatier,Zhijian Cao,Jing-Lin Wang,Patrick Michael McNutt,Yuri N. Utkin,Herve Kovacic,Delavar Shahbazzadeh,Heike Wulff Pdf

Author : Michelle Yap,Cassandra M. Modahl,Steven R. Hall
Publisher : Frontiers Media SA
Page : 165 pages
File Size : 51,8 Mb
Release : 2024-02-23
Category : Science
ISBN : 9782832545232

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Experimental and computational aspects of bioactive proteins from animal venoms: An insight into pharmacological properties and drug discovery by Michelle Yap,Cassandra M. Modahl,Steven R. Hall Pdf

Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.

Author : Jeffrey K. Aronson
Publisher : Elsevier
Page : 7629 pages
File Size : 54,7 Mb
Release : 2015-10-15
Category : Medical
ISBN : 9780444537164

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Meyler's Side Effects of Drugs by Jeffrey K. Aronson Pdf

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company

Author : Anonim
Publisher : Unknown
Page : 754 pages
File Size : 48,6 Mb
Release : 1973
Category : Drugs
ISBN : MINN:31951002687047I

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Toxicity Bibliography by Anonim Pdf

Author : Hang Fai (Henry) Kwok
Publisher : MDPI
Page : 178 pages
File Size : 48,8 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783039211890

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Venom and Toxin as Targeted Therapy by Hang Fai (Henry) Kwok Pdf

Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Author : Katsuhiro Konno,Gandhi Rádis-Baptista
Publisher : MDPI
Page : 404 pages
File Size : 49,8 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9783039285402

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Arthropod Venom Components and Their Potential Usage by Katsuhiro Konno,Gandhi Rádis-Baptista Pdf

Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.

Author : Tom Piek
Publisher : Elsevier
Page : 580 pages
File Size : 41,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483263700

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Venoms of the Hymenoptera by Tom Piek Pdf

Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.

Author : Anonim
Publisher : Unknown
Page : 816 pages
File Size : 54,7 Mb
Release : 1969
Category : Blood coagulation disorders
ISBN : UIUC:30112064854976

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Hemostasis and Thrombosis by Anonim Pdf

Monthly, with annual cumulation. Recurring bibliography from MEDLARS data base. Index medicus format. Entries arranged under subject, review, and author sections. Subject, author indexes.

Author : Anonim
Publisher : Unknown
Page : 824 pages
File Size : 50,8 Mb
Release : 1969
Category : Blood coagulation disorders
ISBN : CORNELL:31924108421763

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Fibrinolysis, Thrombolysis, and Blood Clotting: a Bibliography by Anonim Pdf

Author : Stephen P. Mackessy
Publisher : CRC Press
Page : 681 pages
File Size : 49,6 Mb
Release : 2021-05-24
Category : Nature
ISBN : 9780429623622

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Handbook of Venoms and Toxins of Reptiles by Stephen P. Mackessy Pdf

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1304 pages
File Size : 52,7 Mb
Release : 1965
Category : Medicine
ISBN : IND:30000090423827

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Bernadette F. Rodak,George A. Fritsma,Kathryn Doig
Publisher : Elsevier Health Sciences
Page : 836 pages
File Size : 43,8 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9781416030065

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Hematology by Bernadette F. Rodak,George A. Fritsma,Kathryn Doig Pdf

Textbook explores key aspects of hematology from normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origin. Includes a revised section on hemostasis and thrombosis. Case studies and chapter summaries are included.

Author : Steve Peigneur
Publisher : MDPI
Page : 317 pages
File Size : 49,5 Mb
Release : 2018-05-04
Category : Drug
ISBN : 9783038428619

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Toxins in Drug Discovery and Pharmacology by Steve Peigneur Pdf

This book is a printed edition of the Special Issue "Toxins in Drug Discovery and Pharmacology" that was published in Toxins