Vertebrate Sex Chromosomes

Author : Nobuo Takagi
Publisher : S. Karger AG (Switzerland)
Page : 352 pages
File Size : 50,5 Mb
Release : 2003
Category : Medical
ISBN : 3805576374

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Vertebrate Sex Chromosomes by Nobuo Takagi Pdf

During the last two decades of the 20th century, the study of chromosomes was enormously stimulated by the availability of various biological resources, valuable databases and new genetic and molecular biological techniques including PCR and fluorescent in situ hybridization. The simultaneous development of new and effective systems for targeting genes and gene transfer led to astonishing advances also in the study of vertebrate sex chromosomes. We now have considerable insight into their evolution, the dosage compensation mechanisms in mammals that involve chromosome-wide chromatin remodeling triggered by noncoding Xist RNA, and the unique properties of the human X chromosome which comprises many genes important for sex determination and reproduction. This thematic issue of Cytogenetic and Genome Research presents an excellent and highly authoritative compilation of current research findings related to vertebrate sex chromosomes. The contributions - all prepared by experts in the field - reflect both the technical advances and the enormous gain in knowledge achieved in recent years. Many of these papers also provide important historical perspectives while some contain insightful personal views of the authors. This special volume therefore represents a stimulating and critical state-of-the-art source of information for investigators and students in this fascinating field.

Author : Gerd Scherer,Michael Schmid
Publisher : Birkhäuser
Page : 210 pages
File Size : 54,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783034877817

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Genes and Mechanisms in Vertebrate Sex Determination by Gerd Scherer,Michael Schmid Pdf

Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.

Author : Alberto J. Solari
Publisher : CRC Press
Page : 340 pages
File Size : 41,8 Mb
Release : 1993-10-22
Category : Nature
ISBN : 0849345715

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Sex Chromosomes and Sex Determination in Vertebrates by Alberto J. Solari Pdf

The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs. The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.

Author : Anonim
Publisher : Academic Press
Page : 394 pages
File Size : 43,7 Mb
Release : 2019-04-16
Category : Science
ISBN : 9780128115046

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Sex Determination in Vertebrates by Anonim Pdf

Sex Determination, Volume 134, the latest release in the Current Topics in Developmental Biology series, contains current reviews in the field of vertebrate sex determination. It covers molecular pathways of sex determination in genetic and environmental species and encompasses both sex determination of somatic lineages and commitment of germ cells to male or female fate. Chapters in this new release cover, amongst other topics, Mapping the Sox9 Enhancer Elements, Epigenetic Regulation of Sex Determination, Evolution and Management of Sex Chromosomes, Regulation of Germ Cell Sex Identity in Medaka, Control of Sex Determination in Zebrafish, Sexually Dimorphic Germ Cell Identity in Mammals, and more. Contains reviews written by leading experts in each field Includes informative figures that illustrate principle points that are useful for teaching Written in a style that is clear and simple

Author : Anonim
Publisher : Unknown
Page : 111 pages
File Size : 43,5 Mb
Release : 1999
Category : Electronic
ISBN : OCLC:437106340

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Genes and Mechanisms in Vertebrate Sex Determination by Anonim Pdf

Author : Susumu Ohno
Publisher : Springer Science & Business Media
Page : 201 pages
File Size : 46,6 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642881787

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Sex Chromosomes and Sex-Linked Genes by Susumu Ohno Pdf

Natural selection operates among individual organisms which differ in their genetic constitution. The degree of hereditary variability within a species is greatly enhanced by cross-fertilization. Indeed, the mechanism of sexual reproduction occurred very early in evolution, for it is seen today even in bacteria. In Escherichia coli, fertilization occurs by passage of the single chromosome from the male into the female bacterium (LEDERBERG, 1959). In multicellular organisms, the separation of germ from soma, and the production of haploid gametes became mandatory. The gametes were of two types. One, extremely mobile, was designed to seek out and penetrate the other, which loaded with nutrients, received the mobile gamete and intiated the development of a new individual. The foundation for true bisexuality was thus laid. In the primitive state of bisexuality, whether an individual is to be a sperm-producing male or an egg-producing female appears to be decided rather haphazardly. In the worm, Banelia viridis, the minute males are parasites in the female. Larvae that become attached to the proboscis of an adult female become males, while unattached larvae sink to the bottom and become females (BALTZER, 1935). The more sophisticated state of bisexuality was initiated by setting aside a particular pair of chromosomes for specialization and making either the male or the female a heterogametic sex. Sex chromosomes as we know them were thus born.

Author : Ken Reed,Jennifer A. Marshall Graves
Publisher : Unknown
Page : 410 pages
File Size : 43,6 Mb
Release : 1993
Category : Mammals
ISBN : OCLC:1288479825

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Sex Chromosomes and Sex-determining Genes by Ken Reed,Jennifer A. Marshall Graves Pdf

Author : V. Lance
Publisher : S Karger Ag
Page : 0 pages
File Size : 49,8 Mb
Release : 2003
Category : Medical
ISBN : 3805576889

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Vertebrate Sex Determination by V. Lance Pdf

Author : R. Reinboth
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642660696

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Intersexuality in the Animal Kingdom by R. Reinboth Pdf

When Richard Goldschmidt' coined the term "intersexuality" in 1915, he intended it to apply to normally dioecious species which exhibit some kind of mixture between male and female characters. However, as knowledge of the bewildering variability present in the sexual orga nization of members of the animal kingdom has increased, the original meaning of the word has changed. Today many authors define inter sexuality as "the presence of both male and female characteristics, or of intermediate sexual characteristics, in a single individual".2 This more extensive and widely accepted concept justifies the title of our book •. Among all the anatomical and physiological features of living organisms the reproductive system has a unique importance for the perpetuation of the species. Conversely, reproductive processes are of little or no account for the viability of the individual. Therefore, within the framework of general biology reproduction has all too often been looked at solely from the point of view of genetics. Lively discussions about genotypic versus phenotypic sex determination long dominated the sci entific literature on sexuality in animals; this one-sided emphasis has tended to obscure many important facets of an organism's ability to reproduce. Recent developments in current biological research have brought the classic problem of sex differentiation into focus again, and the rapid progress being made in comparative endocrinology has added a new di mension to the study of reproductive biology.

Author : Nicole Valenzuela,Valentine A. Lance
Publisher : Smithsonian Institution Scholarly Press
Page : 204 pages
File Size : 43,5 Mb
Release : 2004
Category : Science
ISBN : UCSD:31822034180331

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Temperature-Dependent Sex Determination in Vertebrates by Nicole Valenzuela,Valentine A. Lance Pdf

Edited by the world's foremost authorities on the subject, with essays by leading scholars in the field, this work shows how the sex of reptiles and many fish is determined not by the chromosomes they inherit but by the temperature at which incubation takes place.

Author : Kristen J. Navara
Publisher : Springer
Page : 240 pages
File Size : 52,5 Mb
Release : 2018-02-01
Category : Science
ISBN : 9783319712710

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Choosing Sexes by Kristen J. Navara Pdf

There is extensive evidence that vertebrates of all classes have the ability to control the sexes of the offspring they produce. Despite dramatic differences in the mechanisms by which different taxa determine the initial sex of offspring, each group has found its own way of adjusting offspring sex ratios in response to social and environmental cues. For example, stress is a well-known modulator of offspring sex in members of all groups studied to date. Food availability, and limitation in particular, is another common cue that stimulates biases in offspring sex ratios in a wide variety of species. Offspring sex can be adjusted at the primary level, which occurs prior to conception, or at the secondary level, during embryonic development. While the mechanistic pathways that ultimately result in sex ratio biases and the developmental time-points sensitive to those mechanisms likely differ among taxa, the key involvement of steroid hormones in the process of sex ratio adjustment appears to be pervasive throughout. This book reviews the systems of sex determination at play in different vertebrate groups, summarizes the evidence that members of all vertebrate taxa can facultatively adjust offspring sex, and discusses when and how these adjustments can take place.

Author : Ettore Olmo
Publisher : S. Karger AG (Switzerland)
Page : 152 pages
File Size : 42,9 Mb
Release : 2010
Category : Genetic sex determination
ISBN : STANFORD:36105215525515

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Sex Determination and Differentiation in Reptiles by Ettore Olmo Pdf

Reptiles are a fascinating group for the study of sexual development because they exhibit a wide range of sex-determining mechanisms, from strict genetic sex determination (GSD) to strict thermal sex determination (TSD) and intermediate systems of GSD that are to various degrees overridden by environmental effects . This thematic issue presents the latest data on different aspects of sex determination in reptiles. Following an evolutionary perspective on why reptiles might be predisposed to evolve TSD, the papers in this issue explore in detail the different genetic and molecular mechanisms of sex determination and differentiation. They consider recent findings such as the discovery of new genes differentially expressed at male and female sex-determining temperatures, a new model of the role of aromatase, and the contribution of heat-shock proteins to TSD in the American alligator. Further studies examine the role played by sex allocation, the advantage of viviparity, and the effects of anthropogenic climate change on the sex ratio in TSD reptile populations. Providing a valuable overview for both students and researchers, this publication is essential reading for developmental and reproductive biologists, herpetologists, comparative endocrinologists, evolutionary biologists and geneticists.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences
Publisher : National Academies Press
Page : 287 pages
File Size : 45,6 Mb
Release : 2001-07-02
Category : Medical
ISBN : 9780309132978

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Exploring the Biological Contributions to Human Health by Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences Pdf

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Author : C. N. Armstrong,Alan John Marshall
Publisher : Unknown
Page : 502 pages
File Size : 49,8 Mb
Release : 1964
Category : Science
ISBN : UOM:39015000316755

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Intersexuality in Vertebrates Including Man by C. N. Armstrong,Alan John Marshall Pdf

Author : Ulrich Müller,Werner W. Franke
Publisher : Springer
Page : 24 pages
File Size : 46,5 Mb
Release : 1983
Category : Medical
ISBN : CORNELL:31924002073504

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Mechanisms of Gonadal Differentiation in Vertebrates by Ulrich Müller,Werner W. Franke Pdf