Diagnostic And Therapeutic Applications Of Exosomes In Cancer

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Diagnostic and Therapeutic Applications of Exosomes in Cancer

Mansoor M. Amiji,Rajagopal Ramesh
Diagnostic and Therapeutic Applications of Exosomes in Cancer Book PDF

Author : Mansoor M. Amiji,Rajagopal Ramesh
Publisher : Academic Press
Page : 400 pages
File Size : 48,6 Mb
Release : 2018-05-09
Category : Medical
ISBN : 9780128128046

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Diagnostic and Therapeutic Applications of Exosomes in Cancer by Mansoor M. Amiji,Rajagopal Ramesh Pdf

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer. Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment Brings together a team of highly regarded international authors who provide a full-rounded analysis Presents comprehensive coverage of the unique biophysical properties of exosomes Explores current and future possibilities

Mesenchymal Stem Cell Derived Exosomes

Yaoliang Tang,Buddhadeb Dawn
Mesenchymal Stem Cell Derived Exosomes Book PDF

Author : Yaoliang Tang,Buddhadeb Dawn
Publisher : Academic Press
Page : 288 pages
File Size : 54,6 Mb
Release : 2015-09-02
Category : Medical
ISBN : 9780128004975

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Mesenchymal Stem Cell Derived Exosomes by Yaoliang Tang,Buddhadeb Dawn Pdf

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Exosomes

Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble
Exosomes Book PDF

Author : Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble
Publisher : Academic Press
Page : 548 pages
File Size : 44,8 Mb
Release : 2019-10-16
Category : Science
ISBN : 9780128160541

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Exosomes by Larry Edelstein,John R. Smythies,Peter J. Quesenberry,Denis Noble Pdf

Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

Advanced Drug Delivery Systems in the Management of Cancer

Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Advanced Drug Delivery Systems in the Management of Cancer Book PDF

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 43,5 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Endocytosis and Signaling

Christophe Lamaze,Ian Prior
Endocytosis and Signaling Book PDF

Author : Christophe Lamaze,Ian Prior
Publisher : Springer
Page : 329 pages
File Size : 41,6 Mb
Release : 2018-08-10
Category : Science
ISBN : 9783319967042

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Endocytosis and Signaling by Christophe Lamaze,Ian Prior Pdf

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Biomarkers in Breast Cancer

Giampietro Gasparini,Daniel F. Hayes
Biomarkers in Breast Cancer Book PDF

Author : Giampietro Gasparini,Daniel F. Hayes
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 51,7 Mb
Release : 2008-01-17
Category : Medical
ISBN : 9781592599158

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Biomarkers in Breast Cancer by Giampietro Gasparini,Daniel F. Hayes Pdf

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Diagnosis and Treatment of Lung Cancer

Frank C. Detterbeck
Diagnosis and Treatment of Lung Cancer Book PDF

Author : Frank C. Detterbeck
Publisher : Saunders
Page : 512 pages
File Size : 55,5 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015049994703

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Diagnosis and Treatment of Lung Cancer by Frank C. Detterbeck Pdf

Access comprehensive, multidisciplinary guidance on the diagnosis and treatment of lung cancer! This new resource addresses the full range of clinical issues in diagnosis, staging, and treatment, as well as the latest scientific data and evidence-based guidelines. A user-friendlyorganization provides quick reference to data summaries, as well as more comprehensive and detailed information for readers who wish to explore topics in depth. Features contributions by authors from many different disciplines, to ensure a balanced approach. Addresses the clinical issues seen in practice, with the inclusion of basic science research topics that are likely to be put into clinical practice soon. Integrates evidence-based medicine throughout. Assesses the strength of all available dataenabling readers to weigh different arguments and make decisions based on medical issues, values, and the availability and efficacy of interventionsusing a data rating system. Addresses difficult, but clinically relevant issues for which limited data is available. Enables readers to quickly reference findings and data in data summary statements and summary tables.

Role of Exosomes in Biological Communication Systems

Faisal A. Alzahrani,Islam M. Saadeldin
Role of Exosomes in Biological Communication Systems Book PDF

Author : Faisal A. Alzahrani,Islam M. Saadeldin
Publisher : Springer Nature
Page : 373 pages
File Size : 49,6 Mb
Release : 2020-11-20
Category : Medical
ISBN : 9789811565991

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Role of Exosomes in Biological Communication Systems by Faisal A. Alzahrani,Islam M. Saadeldin Pdf

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Exosomes in Cardiovascular Diseases

Junjie Xiao,Sanda Cretoiu
Exosomes in Cardiovascular Diseases Book PDF

Author : Junjie Xiao,Sanda Cretoiu
Publisher : Springer
Page : 307 pages
File Size : 45,8 Mb
Release : 2017-09-19
Category : Science
ISBN : 9789811043970

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Exosomes in Cardiovascular Diseases by Junjie Xiao,Sanda Cretoiu Pdf

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Handbook of Research on Advancements in Cancer Therapeutics

Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Handbook of Research on Advancements in Cancer Therapeutics Book PDF

Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 45,6 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315

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Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Intercellular Communication in Cancer

Mustapha Kandouz
Intercellular Communication in Cancer Book PDF

Author : Mustapha Kandouz
Publisher : Unknown
Page : 128 pages
File Size : 43,6 Mb
Release : 2015
Category : Electronic
ISBN : 9401773815

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Intercellular Communication in Cancer by Mustapha Kandouz Pdf

Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own "kind" or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Exosomes and Microvesicles

Andrew F Hill
Exosomes and Microvesicles Book PDF

Author : Andrew F Hill
Publisher : Humana
Page : 0 pages
File Size : 54,9 Mb
Release : 2016-12-10
Category : Science
ISBN : 1493967266

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Exosomes and Microvesicles by Andrew F Hill Pdf

This volume covers methods for the analysis of extracellular vesicles (EV) that can be applied to isolated EVs from a wide variety of sources. This includes the use of electron microscopy, tunable resistance pulse sensing, and nanoparticle tracking analysis. The chapters in this book discuss EV cargoes containing proteins and genomic materials using a number of different approaches, and isolating EVs from platelets and neuronal cells and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, Exosomes and Microvesicles: Methods and Protocols is a valuable resource containing methodologies for anyone interested in researching EVs.

Cancer Cell Metabolism: A Potential Target for Cancer Therapy

Dhruv Kumar
Cancer Cell Metabolism A Potential Target for Cancer Therapy Book PDF

Author : Dhruv Kumar
Publisher : Springer
Page : 0 pages
File Size : 40,5 Mb
Release : 2021-02-14
Category : Medical
ISBN : 9811519935

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Cancer Cell Metabolism: A Potential Target for Cancer Therapy by Dhruv Kumar Pdf

This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.

Extracellular Vesicles and Their Importance in Human Health

Ana Gil De Bona,Jose Antonio Reales-Calderon
Extracellular Vesicles and Their Importance in Human Health Book PDF

Author : Ana Gil De Bona,Jose Antonio Reales-Calderon
Publisher : BoD – Books on Demand
Page : 172 pages
File Size : 43,9 Mb
Release : 2020-03-04
Category : Science
ISBN : 9781789239430

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Extracellular Vesicles and Their Importance in Human Health by Ana Gil De Bona,Jose Antonio Reales-Calderon Pdf

Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases.

Exploring Pancreatic Metabolism and Malignancy

Ganji Purnachandra Nagaraju,Aramati BM Reddy
Exploring Pancreatic Metabolism and Malignancy Book PDF

Author : Ganji Purnachandra Nagaraju,Aramati BM Reddy
Publisher : Springer Nature
Page : 268 pages
File Size : 55,5 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9789813293939

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Exploring Pancreatic Metabolism and Malignancy by Ganji Purnachandra Nagaraju,Aramati BM Reddy Pdf

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.