Viral Mechanisms Of Immunosuppression

Author : Steven Specter,Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468455830

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Virus-Induced Immunosuppression by Steven Specter,Mauro Bendinelli,Herman Friedman Pdf

It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.

Author : Mark A. Wainberg,Medical Research Council (Canada),Canada. National Advisory Committee on AIDS.
Publisher : New York : A.R. Liss
Page : 312 pages
File Size : 52,5 Mb
Release : 1985
Category : Health & Fitness
ISBN : UCAL:B4531083

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Viral Mechanisms of Immunosuppression by Mark A. Wainberg,Medical Research Council (Canada),Canada. National Advisory Committee on AIDS. Pdf

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 50,9 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Norbert Gilmore
Publisher : Unknown
Page : 284 pages
File Size : 45,6 Mb
Release : 1985
Category : Electronic
ISBN : OCLC:784997852

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Viral Mechanisms of Immunosuppression by Norbert Gilmore Pdf

Author : R. Ahmed,Irvin Chen
Publisher : Wiley-Blackwell
Page : 754 pages
File Size : 52,6 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015041993448

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Persistent Viral Infections by R. Ahmed,Irvin Chen Pdf

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author : Anonim
Publisher : Unknown
Page : 284 pages
File Size : 42,7 Mb
Release : 1985
Category : Immunological deficiency syndromes
ISBN : OCLC:11840404

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Viral Mechanisms of Immunosuppression by Anonim Pdf

Author : Neal Nathanson,Rafi Ahmed
Publisher : Unknown
Page : 240 pages
File Size : 55,6 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015053761865

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Viral Pathogenesis and Immunity by Neal Nathanson,Rafi Ahmed Pdf

This text provides a coherent and concise introduction to the field of viral pathogenesis and immunity. The text is divided into four sections which highlight the fundamental principles within this field of study. Section 1, Essentials of Viral Pathogenesis, describes the sequential events in viral infection, the localization of viral infections and the variety of virus-cell interactions. Section 2, Host Responses to Viral Infection, examines immune responses including virus-induced immunopathology and immunosuppression. Section 3, Virus-Host Interactions, covers virulence, viral persistence, virus-induced oncogenesis and host susceptibility. Section 4, Prevention of Viral Infections, explains the key principles of vaccine development.

Author : Kim A. Brogden,Janet M. Guthmiller
Publisher : Unknown
Page : 460 pages
File Size : 44,5 Mb
Release : 2002
Category : Bacteria
ISBN : UOM:39015055170446

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Polymicrobial Diseases by Kim A. Brogden,Janet M. Guthmiller Pdf

Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.

Author : M. Saveria Campo
Publisher : Elsevier Science & Technology
Page : 0 pages
File Size : 55,7 Mb
Release : 2002
Category : Antigen-antibody reactions
ISBN : 0444511296

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Virus Escape from Immunosurveillance by M. Saveria Campo Pdf

Viruses must be able to overcome the host immune response to replicate themselves and produce infectious progeny. Although eventually the host immune response succeeds in eliminating viruses and virus-infected cells, viruses have evolved a variety of mechanisms to escape immuno surveillance and survive in a hostile environment. In addition to rapid antigenic variation (HIV), latent infection (herpesvirus) or modality of life cycle (papillomaviruses), these mechanisms include the production of viral proteins which actively fight the host immune response. The reviews in this book, written by authors of international renown, deal with the immuno modulators and inhibitors encoded by a variety of viruses, from the poxviruses, which are very well known in this respect, to the papillomaviruses, whose evasion from the host immune response has just begun being elucidated. In addition to being scientifically stimulating, the reviews, by highlighting the countermeasures operated by viruses to fight the host immune response, point the way to new potential anti-viral strategies.

Author : Norbert Gilmore,Mark A. Wainberg
Publisher : Unknown
Page : 302 pages
File Size : 40,8 Mb
Release : 1985-08
Category : Electronic
ISBN : 0471844004

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Viral Mechanisms of Immunosuppression by Norbert Gilmore,Mark A. Wainberg Pdf

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 48,8 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186

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Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Author : Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson
Publisher : Academic Press
Page : 366 pages
File Size : 46,7 Mb
Release : 2015-12-30
Category : Science
ISBN : 9780128011744

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Viral Pathogenesis by Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson Pdf

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Author : Alexander Choukèr
Publisher : Springer Nature
Page : 756 pages
File Size : 52,5 Mb
Release : 2019-11-27
Category : Medical
ISBN : 9783030169961

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Stress Challenges and Immunity in Space by Alexander Choukèr Pdf

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Hans-Georg Rammensee,Jutta Bachmann,Stefan Stevanovic
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 49,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783662221624

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MHC Ligands and Peptide Motifs by Hans-Georg Rammensee,Jutta Bachmann,Stefan Stevanovic Pdf

This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.

Author : Maria S. Salvato
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530282

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The Arenaviridae by Maria S. Salvato Pdf

In this volume, a distinguished international group of contributors present the latest molecular, organismal, and epidemiological research on arenaviruses. Their work will broaden both the clinician's and the researcher's knowledge of basic mechanisms of immunological tolerance, viral immunosuppression, the nature of protective immune responses to vaccination, and viral effects on cell functions.