Visualizing Immunity

Author : Dorian McGavern,Michael Dustin
Publisher : Springer Science & Business Media
Page : 299 pages
File Size : 53,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9783540938644

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Visualizing Immunity by Dorian McGavern,Michael Dustin Pdf

Researchers have used a variety of techniques over the past century to gain fun- mental insights in the field of immunology and, as technology has advanced, so too has the ability of researchers to delve deeper into the biological mechanics of immunity. The immune system is exceedingly complex and must patrol the entire body to protect us from foreign invaders. This requires the immune system to be highly mobile and adaptable - able to respond to diverse microbial challenges while maintaining the ability to distinguish self from a foreign invader. This latter feature is of great importance because the immune system is equipped with toxic mediators, and a failure in self/non-self discrimination can result in serious diseases. Fortunately, in most cases, the immune system operates within the framework of its elegant design and protects us from diverse microbial challenges without initiating disease. Because the immune system is not confined to a single tissue, a comprehensive understanding of immunity requires that research be conducted at the molecular, cellular, and systems level. Immune cells often find customized solutions to h- dling microbial insults that depend on the tissue(s) in which the pathogen is found.

Author : Dorian McGavern,Michael Dustin
Publisher : Springer
Page : 292 pages
File Size : 44,9 Mb
Release : 2010-12-02
Category : Medical
ISBN : 3540938656

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Visualizing Immunity by Dorian McGavern,Michael Dustin Pdf

Researchers have used a variety of techniques over the past century to gain fun- mental insights in the field of immunology and, as technology has advanced, so too has the ability of researchers to delve deeper into the biological mechanics of immunity. The immune system is exceedingly complex and must patrol the entire body to protect us from foreign invaders. This requires the immune system to be highly mobile and adaptable - able to respond to diverse microbial challenges while maintaining the ability to distinguish self from a foreign invader. This latter feature is of great importance because the immune system is equipped with toxic mediators, and a failure in self/non-self discrimination can result in serious diseases. Fortunately, in most cases, the immune system operates within the framework of its elegant design and protects us from diverse microbial challenges without initiating disease. Because the immune system is not confined to a single tissue, a comprehensive understanding of immunity requires that research be conducted at the molecular, cellular, and systems level. Immune cells often find customized solutions to h- dling microbial insults that depend on the tissue(s) in which the pathogen is found.

Author : William J. Liu,Peter Sun,Qihui Wang
Publisher : Frontiers Media SA
Page : 204 pages
File Size : 50,5 Mb
Release : 2023-04-12
Category : Medical
ISBN : 9782832520512

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Crystal clear: Visualizing the immune recognition for the mechanism and intervention by William J. Liu,Peter Sun,Qihui Wang Pdf

Author : Yoshiaki Toyama,Atsushi Miyawaki,Masaya Nakamura,Masahiro Jinzaki
Publisher : Springer Nature
Page : 292 pages
File Size : 47,7 Mb
Release : 2019-10-02
Category : Medical
ISBN : 9789811379086

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Make Life Visible by Yoshiaki Toyama,Atsushi Miyawaki,Masaya Nakamura,Masahiro Jinzaki Pdf

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Author : John Selby
Publisher : Bantam
Page : 228 pages
File Size : 51,9 Mb
Release : 1991
Category : Family & Relationships
ISBN : 0553349694

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Conscious Healing by John Selby Pdf

Recent medical research has determined a direct link between inner emotional and mental habits and the immune system. In the tradition of Creative Visualization, this book gives mind-body relaxation and visualization techniques designed to uplift the immune system, and to protect it from stress as wellas illness.d emotional balancing, proper nutrition, and meditation as aids in achieving long-term results.

Author : Katherine Rowell,Lindsay Betzendahl,Cambria Brown
Publisher : John Wiley & Sons
Page : 243 pages
File Size : 49,7 Mb
Release : 2020-11-10
Category : Computers
ISBN : 9781119680888

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Visualizing Health and Healthcare Data by Katherine Rowell,Lindsay Betzendahl,Cambria Brown Pdf

The only data visualization book written by and for health and healthcare professionals. In health and healthcare, data and information are coming at organizations faster than they can consume and interpret it. Health providers, payers, public health departments, researchers, and health information technology groups know the ability to analyze and communicate this vast array of data in a clear and compelling manner is paramount to success. However, they simply cannot find experienced people with the necessary qualifications. The quickest (and often the only) route to meeting this challenge is to hire smart people and train them. Visualizing Health and Healthcare Data: Creating Clear and Compelling Visualizations to "See how You're Doing" is a one-of-a-kind book for health and healthcare professionals to learn the best practices of data visualization specific to their field. It provides a high-level summary of health and healthcare data, an overview of relevant visual intelligence research, strategies and techniques to gather requirements, and how to build strong teams with the expertise required to create dashboards and reports that people love to use. Clear and detailed explanations of data visualization best practices will help you understand the how and the why. Learn how to build beautiful and useful data products that deliver powerful insights for the end user Follow along with examples of data visualization best practices, including table and graph design for health and healthcare data Learn the difference between dashboards, reports, multidimensional exploratory displays and infographics (and why it matters) Avoid common mistakes in data visualization by learning why they do not work and better ways to display the data Written by a top leader in the field of health and healthcare data visualization, this book is an excellent resource for top management in healthcare, as well as entry-level to experienced data analysts in any health-related organization.

Author : Leandro N. de Castro,Fernando J. Von Zuben,Helder Knidel
Publisher : Springer
Page : 440 pages
File Size : 52,8 Mb
Release : 2007-08-28
Category : Computers
ISBN : 9783540739227

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Artificial Immune Systems by Leandro N. de Castro,Fernando J. Von Zuben,Helder Knidel Pdf

This book constitutes the refereed proceedings of the 6th International Conference on Artificial Immune Systems, ICARIS 2007, held in Santos, Brazil, August 2007. The papers are organized in topical sections on search and optimization, classification and clustering, anomaly detection and negative selection, robotics, control and electronics. Modeling papers, conceptual papers, and technical papers and general applications are also included.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 200 pages
File Size : 46,7 Mb
Release : 2012-01-05
Category : Science
ISBN : 9780309220392

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Chimpanzees in Biomedical and Behavioral Research by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research Pdf

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Author : Mark C. Leake
Publisher : Springer
Page : 362 pages
File Size : 41,6 Mb
Release : 2016-05-18
Category : Science
ISBN : 9783319321899

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Biophysics of Infection by Mark C. Leake Pdf

This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations.

Author : Ronald Hoffman,Edward J. Benz, Jr.,Leslie E. Silberstein,Helen Heslop,John Anastasi,Jeffrey Weitz
Publisher : Elsevier Health Sciences
Page : 2789 pages
File Size : 49,5 Mb
Release : 2013-01-01
Category : Medical
ISBN : 9781437729283

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Hematology by Ronald Hoffman,Edward J. Benz, Jr.,Leslie E. Silberstein,Helen Heslop,John Anastasi,Jeffrey Weitz Pdf

This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself. - Publisher.

Author : Ronald Hoffman,Edward J. Benz,Leslie E. Silberstein,Helen Heslop,Jeffrey Weitz,John Anastasi
Publisher : Elsevier Health Sciences
Page : 2789 pages
File Size : 41,7 Mb
Release : 2013-03-29
Category : Medical
ISBN : 9781455776887

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Hematology: Diagnosis and Treatment E-Book by Ronald Hoffman,Edward J. Benz,Leslie E. Silberstein,Helen Heslop,Jeffrey Weitz,John Anastasi Pdf

The Hematology: Diagnosis and Treatment eBook is the ideal mobile resource in hematology! It distills the most essential, practical information from Hematology: Basic Principles and Practice, 6th Edition - the comprehensive masterwork by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi - into a concise, clinically focused resource that's optimized for reference on any e-reader. Focusing on the dependable, state-of-the-art clinical strategies you need to optimally diagnose and manage the full range of blood diseases and disorders, this eBook is a must-have for every hematologist's mobile device! Apply the latest know-how on heparin-induced thrombocytopenia, stroke, acute coronary syndromes, hematologic manifestations of liver disease, hematologic manifestations of cancer, hematology in aging, and many other hot topics. Get quick, focused answers on the diagnosis and management of blood diseases - in a portable digital format that you can carry and consult anytime, anywhere. View abundant images that mirror the pivotal role hematopathology plays in the practice of modern hematology. Count on all the authority that has made Hematology: Basic Principles and Practice, 6th Edition, edited by Drs. Hoffman, Benz, Silberstein, Heslop, Weitz, and Anastasi, the go-to clinical reference for hematologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

Author : Irving C. Allen
Publisher : Humana
Page : 0 pages
File Size : 49,7 Mb
Release : 2016-08-27
Category : Medical
ISBN : 1493960369

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Mouse Models of Innate Immunity by Irving C. Allen Pdf

The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.

Author : Rodney P. Anderson,Linda Young
Publisher : John Wiley & Sons
Page : 766 pages
File Size : 52,5 Mb
Release : 2017-08-14
Category : Science
ISBN : 9781119443124

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Visualizing Microbiology by Rodney P. Anderson,Linda Young Pdf

Visualizing Microbiology, 1st Edition provides an introduction to microbiology for students who require the basic fundamentals of microbiology as a requirement for their major or course of study. The unique visual pedagogy of the Visualizing series provides a powerful combination of content, visuals, multimedia and videos ideal for microbiology. A dynamic learning platform encouraging engagement with real clinical content, Visualizing Microbiology also brings the narrative to life with integrated multimedia helping students see and understand the unseen in the world of microbiology.

Author : Pamela A. Kozlowski
Publisher : Springer Science & Business Media
Page : 204 pages
File Size : 51,6 Mb
Release : 2012-01-13
Category : Medical
ISBN : 9783642236921

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Mucosal Vaccines by Pamela A. Kozlowski Pdf

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Author : Ulrich Dobrindt,Jörg H. Hacker,Catharina Svanborg
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 55,9 Mb
Release : 2014-07-08
Category : Medical
ISBN : 9783642365607

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Between Pathogenicity and Commensalism by Ulrich Dobrindt,Jörg H. Hacker,Catharina Svanborg Pdf

This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals. The ongoing development of (meta-)genomic, transcriptomic, proteomic and bioinformatic analyses of pathogenic and commensal microorganisms and their host interaction provides a comprehensive introduction to the microbiological analysis of host-microbe interplay and its consequences for infection or commensalism.