Xenobiotics And Inflammation

Author : Schook,Lashkin
Publisher : Academic Press
Page : 384 pages
File Size : 50,5 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323140362

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Xenobiotics and Inflammation by Schook,Lashkin Pdf

The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.

Author : D.J. Smith,William H. Gingerich,Maria G. Beconi-Barker
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461547037

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Xenobiotics in Fish by D.J. Smith,William H. Gingerich,Maria G. Beconi-Barker Pdf

Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.

Author : James J. Kocsis,David J. Jollow,Charlotte M. Witmer,Judd O. Nelson,Robert R. Snyder
Publisher : Springer Science & Business Media
Page : 1028 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468451344

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Biological Reactive Intermediates III by James J. Kocsis,David J. Jollow,Charlotte M. Witmer,Judd O. Nelson,Robert R. Snyder Pdf

This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 45,5 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author : Wen Xie
Publisher : Academic Press
Page : 294 pages
File Size : 48,7 Mb
Release : 2016-09-12
Category : Medical
ISBN : 9780128029633

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Drug Metabolism in Diseases by Wen Xie Pdf

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Author : Raman Mehrzad
Publisher : Academic Press
Page : 298 pages
File Size : 48,7 Mb
Release : 2022-09-24
Category : Medical
ISBN : 9780323909617

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Inflammation and Obesity by Raman Mehrzad Pdf

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients. Identifies the hidden physiological changes that accompany obesity, while also highlighting the challenge of managing obesity with a higher inflammatory response Discusses major hidden health risks of inflammation that accompany obesity, as well as management guidelines for obese patients Links the pathophysiology of inflammation and obesity to the therapeutic strategies that minimizes risk factors, thus opening new areas of research

Author : Reza Heidari,M. Mehdi Ommati
Publisher : Bentham Science Publishers
Page : 344 pages
File Size : 46,9 Mb
Release : 2023-03-31
Category : Medical
ISBN : 9789815124491

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Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases by Reza Heidari,M. Mehdi Ommati Pdf

Taurine, or 2aminoethanesulfonic acid, is one of the most abundant sulfurcontaining amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements. Topics covered in this reference include Synthesis of taurine and its dietary sources The Role of taurine in mitochondrial health Taurine as a neurotransmitter Beneficial effects of taurine in physiological systems such as the reproductive system, renal system, and the gastrointestinal tract Hepatoprotective and antiinflammatory properties of taurine The antiaging promise of taurine supplementation Role of taurine supplementation in obesity

Author : Robert R. Snyder,James J. Kocsis,I. Glenn Sipes,George F. Kalf,David J. Jollow,Helmut Greim,Terrence J. Monks,Charlotte M. Witmer
Publisher : Springer Science & Business Media
Page : 449 pages
File Size : 51,5 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781475794809

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Biological Reactive Intermediates V by Robert R. Snyder,James J. Kocsis,I. Glenn Sipes,George F. Kalf,David J. Jollow,Helmut Greim,Terrence J. Monks,Charlotte M. Witmer Pdf

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Author : José A. Agúndez,Kathrin Klein
Publisher : Frontiers E-books
Page : 198 pages
File Size : 41,8 Mb
Release : 2013-07-05
Category : Electronic
ISBN : 9782889191420

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Functional Polymorphisms of Xenobiotics Metabolizing Enzymes (XME) by José A. Agúndez,Kathrin Klein Pdf

Author : Huai Deng
Publisher : Springer Nature
Page : 211 pages
File Size : 53,8 Mb
Release : 2020-05-21
Category : Medical
ISBN : 9783030445997

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Nrf2 and its Modulation in Inflammation by Huai Deng Pdf

Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.

Author : James R. Hebert,Lorne J Hofseth
Publisher : Academic Press
Page : 928 pages
File Size : 51,6 Mb
Release : 2022-04-28
Category : Health & Fitness
ISBN : 9780128221655

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Diet, Inflammation, and Health by James R. Hebert,Lorne J Hofseth Pdf

Diet, Inflammation, and Health introduces concepts of inflammation, the role of acute inflammatory responses in good health, and the association of chronic systemic inflammation with mental distress, cognitive decline, and chronic diseases, ranging from diabetes to cardiovascular diseases, stroke, and cancer. The book also describes the pathophysiology of inflammation and its effects on insulin insensitivity and blunted immune response to carcinogenesis. Researchers and allied health care professionals working in dietetics and medicine, as well as students studying related fields will benefit from this reference and its recommendations on areas where future research is needed. Addresses the role of acute inflammatory responses in achieving and maintaining good health Covers the association of chronic system inflammation with various conditions and diseases Describes the effect of inflammation on mechanisms ranging from insulin insensitivity and immune response to carcinogenesis

Author : Larry P. Tilley,Francis W. K. Smith, Jr.,Meg M. Sleeper,Benjamin M. Brainard
Publisher : John Wiley & Sons
Page : 1728 pages
File Size : 43,6 Mb
Release : 2021-03-11
Category : Medical
ISBN : 9781119513155

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Blackwell's Five-Minute Veterinary Consult by Larry P. Tilley,Francis W. K. Smith, Jr.,Meg M. Sleeper,Benjamin M. Brainard Pdf

The very latest information on diseases and clinical problems in dogs and cats Blackwell's Five-Minute Veterinary Consult: Canine and Feline, 7th Edition provides up-to-date information on feline and canine disease in the familiar, popular, and trusted 5-Minute Veterinary Consult format. This reference puts all the necessary information regarding common diseases and conditions in dogs and cats at the reader’s fingertips. Covering 845 specific disorders, Blackwell’s Five-Minute Veterinary Consult is the most comprehensive and timely reference on canine and feline medicine available today. It is carefully designed for fast and easy access to vital and accurate information. The companion website allows the reader to access more than 350 downloadable client education handouts, as well as images and video clips. The book makes it easy to find essential details on: 845 different diseases and conditions, from amebiasis to zinc toxicosis Diagnosis Common treatments and prognoses Blackwell’s Five-Minute Veterinary Consult: Canine and Feline is the leading quick-access reference for veterinary practitioners and students everywhere.

Author : Thomas Kaufmann,W. Wei-Lynn Wong
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 44,9 Mb
Release : 2020-05-21
Category : Electronic
ISBN : 9782889636952

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Connecting the Dots Between Inflammation and the Inner Workings of Programmed Cell Death by Thomas Kaufmann,W. Wei-Lynn Wong Pdf

Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependent necroptosis, resulting in a necrotic phenotype, and pyroptosis. Interestingly, key components of the necroptotic pathway are actively suppressed by apoptotic caspases, and this interconnection allows a switch in cell death modalities with greatly impact on the host’s immune response. Recent findings link mitochondria and/or MOMP to non-apoptotic forms of PCD, including ferroptosis and necroptosis, putting this organelle even more in the center of cellular death. This article collection highlights the exciting potential and as yet undiscovered regulation of programmed cell death that can impact the immune system and its response.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 51,9 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Camino Gestal,Santiago Pascual,Ángel Guerra,Graziano Fiorito,Juan M. Vieites
Publisher : Springer
Page : 234 pages
File Size : 52,9 Mb
Release : 2019-03-07
Category : Science
ISBN : 9783030113308

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Handbook of Pathogens and Diseases in Cephalopods by Camino Gestal,Santiago Pascual,Ángel Guerra,Graziano Fiorito,Juan M. Vieites Pdf

The aim of this open access book is to facilitate the identification and description of the different organs as well as pathogens and diseases affecting the most representative species of cephalopods focussed on Sepia officinalis, Loligo vulgaris and Octopus vulgaris. These species are valuable ‘morphotype’ models and belong to the taxonomic groups Sepioidea, Myopsida and Octopoda, which include most of the species with a high market value and aquaculture potential. The study is based on photographs at macroscopic and histological level in order to illustrate the role of the most important pathogens and related diseases from the view of a pathological diagnosis. The reader is able to familiarize with functional anatomy, necropsy and general histology of adults and paralarvae, as well as with the identification of different pathogens and pathologies. This work is thus an invaluable guide for the diagnosis of cephalopod diseases. Besides including pathogens for non-European cephalopod species, it also provides a useful contribution encouraging marine pathologists, parasitologists, veterinarians and those involved in fishery sanitary assessments, aquarium maintenance and aquaculture practices aiming to increase their knowledge about the pathology of cephalopods.