A Glance At Advances In The Techniques And Methodologies Of Cancer Gene Therapy

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A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy.

Dr.Hakim Saboowala
A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy Book PDF

Author : Dr.Hakim Saboowala
Publisher : Dr.Hakim Saboowala
Page : 57 pages
File Size : 55,7 Mb
Release : 2020-05-06
Category : Medical
ISBN : 8210379456XXX

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A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. by Dr.Hakim Saboowala Pdf

A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. Cancer is the second leading cause of mortality worldwide after cardiovascular diseases, predominantly due to the lack of early symptoms and early diagnosis, and high relapse rate after radical surgery and conventional therapies. Therefore, novel approaches such as gene therapy have raised hope to significantly improve the survival rate of patients with cancers. Thus it would be worth at this stage providing an up-to-date information concerning gene therapy including: · Improved vectors, · Suicide genes, · Cancer suppressor genes, · Anti-tumor angiogenesis, · Gene silencing, · Oncolytic virotherapy, and · Gene-editing technology. Whilst specific issues still exist before gene therapy can completely cure cancers, an effort has been made in this Booklet to highlight the potential of gene therapy in cancer treatment and expect to see continuous breakthroughs in techniques therapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Cancer Gene Therapy

David T. Curiel,Joanne T. Douglas
Cancer Gene Therapy Book PDF

Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 55,6 Mb
Release : 2007-11-03
Category : Medical
ISBN : 9781592597857

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Cancer Gene Therapy by David T. Curiel,Joanne T. Douglas Pdf

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Gene-Based Therapies for Cancer

Jack A. Roth
Gene Based Therapies for Cancer Book PDF

Author : Jack A. Roth
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 50,6 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9781441961020

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Gene-Based Therapies for Cancer by Jack A. Roth Pdf

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Gene Therapy of Solid Cancers

Wolfgang Walther,Ulrike Stein
Gene Therapy of Solid Cancers Book PDF

Author : Wolfgang Walther,Ulrike Stein
Publisher : Humana
Page : 0 pages
File Size : 55,7 Mb
Release : 2016-10-09
Category : Medical
ISBN : 1493955926

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Gene Therapy of Solid Cancers by Wolfgang Walther,Ulrike Stein Pdf

This volume provides insight into recent developments on experimental and clinical strategies for cancer gene therapy. Gene Therapy of Solid Cancers: Methods and Protocols guides readers through protocols on gene therapeutic strategies in combination with helpful technical notes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, Gene Therapy of Solid Cancers: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Gene Therapy of Cancer

Wolfgang Walther,Ulrike S. Stein
Gene Therapy of Cancer Book PDF

Author : Wolfgang Walther,Ulrike S. Stein
Publisher : Humana Press
Page : 738 pages
File Size : 53,8 Mb
Release : 2009-08-14
Category : Medical
ISBN : 1603279431

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Gene Therapy of Cancer by Wolfgang Walther,Ulrike S. Stein Pdf

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. "Gene Therapy of Cancer: Methods and Protocols, Second Edition" fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, "Gene Therapy of Cancer: Methods and Protocols, Second Edition" is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.

Gene Therapy for Cancer

Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Gene Therapy for Cancer Book PDF

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 49,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Global Epidemiology of Cancer

Jahangir Moini,Nicholas G. Avgeropoulos,Craig Badolato
Global Epidemiology of Cancer Book PDF

Author : Jahangir Moini,Nicholas G. Avgeropoulos,Craig Badolato
Publisher : John Wiley & Sons
Page : 676 pages
File Size : 45,6 Mb
Release : 2022-03-22
Category : Medical
ISBN : 9781119817185

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Global Epidemiology of Cancer by Jahangir Moini,Nicholas G. Avgeropoulos,Craig Badolato Pdf

GLOBAL EPIDEMIOLOGY OF CANCER Cancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are key factors that each government and population must be aware of. Advances in the study of cancer occur on a regular basis, and this book provides the latest insights about relationships between the disease and stem cells, tumorigenesis, molecular interactions, pathways, channels, and immunity. Global Epidemiology of Cancer: Diagnosis and Treatment meets the needs of readers by providing current information about epidemiology (including molecular epidemiology), diagnosis, and treatment. Providing logical, step-by-step information on various cancers, this book consolidates all of the most up-to-date information and data from verified studies on all different types of cancers in the United States and throughout the world. Chapters are presented so that each includes an overview, clinical manifestations, epidemiology, pathophysiology, etiology and risk factors, diagnosis, treatment, prevention, and prognosis. Global Epidemiology of Cancer: Diagnosis and Treatment will be invaluable to graduate and postgraduate students, including medical students; nurses; physician assistants; residents in oncology; public health students and allied health students.

From Research to Reality

The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada
From Research to Reality Book PDF

Author : The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada
Publisher : Council of Canadian Academies
Page : 122 pages
File Size : 48,9 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9781926522791

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From Research to Reality by The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada Pdf

From Research to Reality describes the stages involved in the approval and use of gene therapies in Canada, and examines challenges associated with regulatory oversight, manufacturing, access, and affordability, and identifies promising approaches to address them.

Immunopharmacology

Manzoor M. Khan
Immunopharmacology Book PDF

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 42,7 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387779768

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Immunopharmacology by Manzoor M. Khan Pdf

During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Loutfy H. Madkour
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book PDF

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 55,7 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Mammography and Beyond

National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer
Mammography and Beyond Book PDF

Author : National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer
Publisher : National Academies Press
Page : 34 pages
File Size : 49,9 Mb
Release : 2001-06-04
Category : Medical
ISBN : 9780309075503

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Mammography and Beyond by National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer Pdf

X-ray mammography screening is the current mainstay for early breast cancer detection. It has been proven to detect breast cancer at an earlier stage and to reduce the number of women dying from the disease. However, it has a number of limitations. These current limitations in early breast cancer detection technology are driving a surge of new technological developments, from modifications of x-ray mammography such as computer programs that can indicate suspicious areas, to newer methods of detection such as magnetic resonance imaging (MRI) or biochemical tests on breast fluids. To explore the merits and drawbacks of these new breast cancer detection techniques, the Institute of Medicine of the National Academy of Sciences convened a committee of experts. During its year of operation, the committee examined the peer-reviewed literature, consulted with other experts in the field, and held two public workshops. In addition to identifying promising new technologies for early detection, the committee explored potential barriers that might prevent the development of new detection methods and their common usage. Such barriers could include lack of funding from agencies that support research and lack of investment in the commercial sector; complicated, inconsistent, or unpredictable federal regulations; inadequate insurance reimbursement; and limited access to or unacceptability of breast cancer detection technology for women and their doctors. Based on the findings of their study, the committee prepared a report entitled Mammography and Beyond: Developing Technology for Early Detection of Breast Cancer, which was published in the spring of 2001. This is a non-technical summary of that report.

Epigenetic Technological Applications

Yujun George Zheng
Epigenetic Technological Applications Book PDF

Author : Yujun George Zheng
Publisher : Academic Press
Page : 516 pages
File Size : 51,8 Mb
Release : 2015-05-30
Category : Science
ISBN : 9780128013274

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Epigenetic Technological Applications by Yujun George Zheng Pdf

Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics

Oversight and Review of Clinical Gene Transfer Protocols

Institute of Medicine,Board on Health Sciences Policy,Committee on the Independent Review and Assessment of the Activities of the NIH Recombinant DNA Advisory Committee
Oversight and Review of Clinical Gene Transfer Protocols Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on the Independent Review and Assessment of the Activities of the NIH Recombinant DNA Advisory Committee
Publisher : National Academies Press
Page : 134 pages
File Size : 41,9 Mb
Release : 2014-03-27
Category : Medical
ISBN : 9780309296656

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Oversight and Review of Clinical Gene Transfer Protocols by Institute of Medicine,Board on Health Sciences Policy,Committee on the Independent Review and Assessment of the Activities of the NIH Recombinant DNA Advisory Committee Pdf

Gene transfer research is a rapidly advancing field that involves the introduction of a genetic sequence into a human subject for research or diagnostic purposes. Clinical gene transfer trials are subject to regulation by the U.S. Food and Drug Administration (FDA) at the federal level and to oversight by institutional review boards (IRBs) and institutional biosafety committees (IBCs) at the local level before human subjects can be enrolled. In addition, at present all researchers and institutions funded by the National Institutes of Health (NIH) are required by NIH guidelines to submit human gene transfer protocols for advisory review by the NIH Recombinant DNA Advisory Committee (RAC). Some protocols are then selected for individual review and public discussion. Oversight and Review of Clinical Gene Transfer Protocols provides an assessment of the state of existing gene transfer science and the current regulatory and policy context under which research is investigated. This report assesses whether the current oversight of individual gene transfer protocols by the RAC continues to be necessary and offers recommendations concerning the criteria the NIH should employ to determine whether individual protocols should receive public review. The focus of this report is on the standards the RAC and NIH should use in exercising its oversight function. Oversight and Review of Clinical Gene Transfer Protocols will assist not only the RAC, but also research institutions and the general public with respect to utilizing and improving existing oversight processes.

Developing Technologies for Early Detection of Breast Cancer

National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer,Laura Newman
Developing Technologies for Early Detection of Breast Cancer Book PDF

Author : National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer,Laura Newman
Publisher : National Academies Press
Page : 24 pages
File Size : 40,7 Mb
Release : 2000-07-06
Category : Medical
ISBN : 9780309183956

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Developing Technologies for Early Detection of Breast Cancer by National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer,Laura Newman Pdf

In November 1999, the Institute of Medicine, in consultation with the Commission on Life Sciences, the Commission on Physical Sciences, Mathematics, and Applications, and the Board on Science, Technology and Economic Policy launched a one year study on technologies for early detection of breast cancer. The committee was asked to examine technologies under development for early breast cancer detection, and to scrutinize the process of medical technology development, adoption, and dissemination. The committee is gathering information on these topics for its report in a number of ways, including two public workshops that bring in outside expertise. The first workshop on "Developing Technologies for Early Breast Cancer Detection" was held in Washington DC in February 2000. The content of the presentations at the workshop is summarized here. A second workshop, which will focus on the process of technology development and adoption, will be held in Washington, DC on June 19-20. A formal report on these topics, including conclusions and recommendations, will be prepared by the committee upon completion of the one-year study.

Ex Vivo Cell Therapy

Klaus Schindhelm,Robert Nordon
Ex Vivo Cell Therapy Book PDF

Author : Klaus Schindhelm,Robert Nordon
Publisher : Academic Press
Page : 392 pages
File Size : 53,5 Mb
Release : 1999
Category : Health & Fitness
ISBN : UOM:39015042794654

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Ex Vivo Cell Therapy by Klaus Schindhelm,Robert Nordon Pdf

R.E. Nordon and K. Schindhelm, Introduction. -- L. Robb, A.G. Elefanty, and C.G. Begley, Transcriptional Control of Hematopoieses. -- R. Starr and N.A. Nicola, Cell Signaling by Hemopoietic Growth Factor Receptors. -- P.J. Simmons, D.N. Haylock, and J.-P. Lévesque, Influence of Cytokines and Adhesion Molecules on Hematopoietic Stem Cell Development. -- P.A. Rowlings, Allogeneic Hematopoietic Stem Cell Transplantation. -- U. Hahn and L.B. To, Autologous Stem Cell Transplantation. -- M.R. Vowels, Cord Blood Stem Cell Transplantation. -- S.R. Riddell, E.H. Warren, D. Lewinsohn, C. Yee, and P.D. Greenberg, Reconstitution of Immunity by Adoptive Immunotherapy with T Cells. -- L.Q. Sun, M. Miller, and G. Symonds, Exogenous Gene Transfer into Lymphoid and Hematopoietic Progenitor Cells. -- C. Dowding, T. Leemhuis, A. Jakubowski, and C. Reading, Process Development for Ex Vivo Cell Therapy. -- R.E. Nordon and K. Schindhelm, Cell Separation. -- P.W. Zandstra, C.J. Eaves, and J.M. Piret, Environ ...