Adenosine Cardioprotection And Its Clinical Application

Author : Robert M. Mentzer Jr.,Masafumi Kitakaze,James M. Downey,Masatsugu Hori
Publisher : Springer Science & Business Media
Page : 239 pages
File Size : 48,5 Mb
Release : 2012-09-10
Category : Medical
ISBN : 9781441987365

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Adenosine, Cardioprotection and Its Clinical Application by Robert M. Mentzer Jr.,Masafumi Kitakaze,James M. Downey,Masatsugu Hori Pdf

The immense growth in the number of articles on adenosine cardioprotection in recent years has been related in large part to the hypothesis that adenosine plays a role in ischemic preconditioning. Ischemic preconditioning is the phenomenon in which a brief period of ischemia (and reperfusion) prior to a more prolonged occlusion reduces myocardial infarct size. This form of myocardial protection has received much interest because ischemic preconditioning has been shown to be the most potent means of reducing infarct size in all animal models so far tested. Within the last six years, the principal focus of adenosine cardioprotection research has centered on the role of adenosine receptors. It is currently thought that adenosine protects the ischemic heart primarily via the activation of adenosine A1 receptors located on the cardiac myocytes. Adenosine is used clinically for terminating supraventricular tachycardia, and as a diagnostic tool in coronary imaging, and has been used postoperatively for blood pressure control after heart surgery. There are also recent reports that adenosine may be safely tolerated and a potentially beneficial additive to cardioplegic solutions during open heart surgery in humans. There is even evidence that ischemic preconditioning may occur in humans under various clinical situations. This volume contains chapters from contributors to the first three symposia on 'Adenosine, Cardioprotection, and its Clinical Application'. All aspects of adenosine cardioprotection and ischemic preconditioning, including potential mechanisms and clinical applications, are discussed by experts in these areas. The reader will find this book to be an excellent source of information on these topics, as well as a guide to future experiments.

Author : G.F. Baxter,Derek M. Yellon
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401153126

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Delayed Preconditioning and Adaptive Cardioprotection by G.F. Baxter,Derek M. Yellon Pdf

Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

Author : Tomas A. Salerno,Marco Ricci
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 48,5 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405178433

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Myocardial Protection by Tomas A. Salerno,Marco Ricci Pdf

Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.

Author : P.A.F.M. Doevendans,A.A.M. de Wilde
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 49,6 Mb
Release : 2001-10-31
Category : Medical
ISBN : 1402000979

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Cardiovascular Genetics for Clinicians by P.A.F.M. Doevendans,A.A.M. de Wilde Pdf

All physicians practicing medicine encounter patients suffering from cardiovascular disease. This book has been outlined in such a way that vascular surgeons, general internists, neurologists and cardiologists should be able to use it. The book covers the complete scope of cardiac diseases in addition to chapters on hypertension and atherosclerosis. In many patients there is a family history of cerebrovascular accidents, myocardial infarction or peripheral arterial disease. Also in patients reporting collaps, palpitations and arrhythmias the family is crucial and can provide clues to a genetic cause of the disease. This book is published to guide physicians in the process of determining whether a genetic component is likely to be present. Furthermore, information is provided what the possibilities and limitations of DNA diagnostic techniques are. Finally, the importance of newly identified categories of potential patients, i. e. gene carriers without symptoms or any inducible sign of disease, is highlighted. For some patients a genetic diagnosis is essential to determine appropriate therapy and for counseling? In some other diseases DNA diagnostic tools are available but the relevant for the patients may be less clear. In other families the search for a disease causing gene is ongoing and the possibilities to find genes and to unravel the pathophysiology of the disease is limited by the lack of patients. To give insight into the current state of genetic diagnostics, the authors have classified the cardiovascular diseases.

Author : R. Masters
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 42,9 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9780585291918

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Surgical Options for the Treatment of Heart Failure by R. Masters Pdf

Despite the significant decline in heart disease mortaht>' rates over the last 25 years, heart failure has remained a significant problem. We are now confronted with large numbers of terminally ill patients for whom conventional therapies for heart failure have been exhausted and for whom repeated hospital visits are necessary. There now is a major thrust towards a management strategy which embraces a comprehensive approach including vigorous preventive measures and earlier surgical interventions. This book outlines the major surgical options for the treatment of heart failure and brings together a very broad base of opinions with contributions from several outstanding individuals. With the improved knowledge and techniques to control rejection, transplantation has become the central pillar in the surgical management of this group of patients. Unfortunately, because of limited donor supply the teclmique cannot be applied to large numbers of patients. A great deal of excitement, however, exists in the potential for xenotransplantation as a supplement to homotransplantation. The use of cardiac assist devices has become a reality with several hundred LVADS and BiVADS implanted throughout the world and cardiac replacement with total artificial hearts continues to be used successfully as a bridge to transplantation. We are on the thieshold of the broad application of assist devices to provide prolonged relief of heart failure and restore patients to an ambulatoiy home environment and hopefully return to the work force in significant numbers.

Author : Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi
Publisher : Humana Press
Page : 593 pages
File Size : 44,5 Mb
Release : 2018-07-28
Category : Medical
ISBN : 9783319908083

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The Adenosine Receptors by Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi Pdf

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Author : P.E. Vardas
Publisher : Springer Science & Business Media
Page : 461 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401152549

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Cardiac Arrhythmias, Pacing & Electrophysiology by P.E. Vardas Pdf

Europace '97 was held in Athens, Greece, on 8-11 June Leads were, as usual, an important topic, with the earl 1997 in the city of classical civilisation and learning. iest mention of the then-new polyurethane leads. Future Though now held in modem surroundings and meeting conferences elaborated on these basic topics while pro facilities, the influence of the ancient city-state was un gressively adding sensors and sensor function, dual mistakable, with the architecture and learning of antiquity chamber pacing, and recognising the development of looming over the city, by its influence over the intellectual clinical cardiac electrophysiology. activities of the symposium. The ancient magnificence of Clinical cardiac electrophysiology and compre the site was matched by the novelty of modem art and hension of arrhythmias has been largely a development science, Europace is a European symposium, begun in of the twentieth century. With the description and 1979, and has occurred every second year since. Con recording of the bundle of His depolarisation, by direct sistent with its importance and continental reach the actual access and by catheter, modem clinical investigation of symposium has moved to different cities throughout arrhythmias and cardiac electrophysiology began. The Western Europe. The first symposium was held in London disciplines of cardiac stimulation and of investigation of and subsequent symposia have been held in Torremolinos, arrhythmias, impulse formation and A V conduction Ostend, Florence, Istanbul and other cities. Because of the were essentially separate for many years.

Author : Francisco Ciruela,Kenneth A. Jacobson
Publisher : Frontiers Media SA
Page : 852 pages
File Size : 48,5 Mb
Release : 2019-08-16
Category : Electronic
ISBN : 9782889459476

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Purinergic Pharmacology by Francisco Ciruela,Kenneth A. Jacobson Pdf

Author : P.A.F.M. Doevendans,Robert S. Reneman,Marc van Bilsen
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 52,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789401593212

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Cardiovascular Specific Gene Expression by P.A.F.M. Doevendans,Robert S. Reneman,Marc van Bilsen Pdf

Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made.

Author : S. Gupta,A.J. Camm
Publisher : Springer Science & Business Media
Page : 160 pages
File Size : 43,9 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585375984

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Chronic Infection, Chlamydia and Coronary Heart Disease by S. Gupta,A.J. Camm Pdf

Coronary heart disease (CHD) remains a major cause of human mortality and morbidity worldwide. Classical risk factors for atherosclerosis fail to account fully for the wide variations in CHD prevalence and/or severity between differing populations. The search for hitherto unrecognised risk factors has recently focused on the potential role of chronic inflammation and common infections. Chronic Infection, Chlamydia and Coronary Heart Disease is the first book to review the wealth of evidence linking various infective agents with CHD, focusing particularly on the proposed pathogenetic role of the main candidate microorganism, Chlamydia pneumoniae. Written by two leading investigators in the field, the book provides a concise, clearly written and up-to-date account of the diverse lines of evidence - seroepidemiological, pathological, animal and in vitro data and clinical antibiotic trials. The possibility of an infective basis to atherosclerosis and CHD has already attracted much scientific interest. Chronic Infection, Chlamydia and Coronary Heart Disease highlights the key published works on the topic, and concludes with information on existing, ongoing, and future lines of enquiry.

Author : A.E. Iskandrian,Ernst E. van der Wall
Publisher : Springer Science & Business Media
Page : 247 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401140805

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Myocardial Viability by A.E. Iskandrian,Ernst E. van der Wall Pdf

AMI E. ISKANDRIAN & ERNST E. VAN DER WALL The first edition of this book was published in 1994. Since then important advances have occurred in the field of myocardial viability. This, coupled with increasing interest by the scientific community in the broader issues of its relevance to patient care, suggested to us the need to write the second edition. We are most fortunate to have the help of a distinguished group of experts who have helped shape the field; we appreciate their commitments and contributions. Almost all chapters have been radically modified. Chapter 1 deals with pathophysiology of myocardial hibernation and stunning; Chapter 2 with apoptosis; Chapter 3 with the role of positron emission tomography; Chapters 4 and 5 with the role of single photon emission computed tomography with thallium-201 and technetium agents, respectively; Chapter 6 with the role of SPECT fatty acid imaging; Chapter 7 with the role of SPECT FDG imaging; Chapter 8 with the role of cardiac catheterization angiography; Chapter 9 with the role of echocardiography; Chapter 10 with the role of magnetic resonance imaging; and Chapter 11 with clinical applications. Finally, Chapter 12 provides a short summary.

Author : C.A. Nienaber,R. Fattori
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 41,9 Mb
Release : 1999-03-31
Category : Medical
ISBN : 0792355172

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Diagnosis and Treatment of Aortic Diseases by C.A. Nienaber,R. Fattori Pdf

Describes recent surgical techniques developed to improve prognosis in aortic diseases, and discusses recent interventional strategies such as endovascular stent-graft placement and non-surgical reconstruction of the aorta. Chapters deal with aortic dissection, aortic aneurysm, surgical treatment of aortic aneurysms and dissections, inherited disorders of the aorta, aortic trauma, aortitis, and etiology and pathology of aortic malformations. Each chapter is organized in a similar fashion, with information on demographic aspects, pathology, clinical presentation, and diagnostic and therapeutic approaches. Annotation copyrighted by Book News, Inc., Portland, OR

Author : Karl A. Fox
Publisher : Springer Science & Business Media
Page : 278 pages
File Size : 55,5 Mb
Release : 1997-11-30
Category : Medical
ISBN : 0792380363

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Social System Accounts by Karl A. Fox Pdf

Non-Invasive Imaging of Atherosclerosis is a primer, reference and review of some of the key features of current activities in the field of atherosclerosis. The Editors' goal is to provide material and stimulating ideas to basic scientists and clinical researchers in order to extend the application of vascular imaging and to further develop methods suitable for investigation of the arterial wall. The first section presents current knowledge about pathology, vascular mechanics and compensatory mechanisms active during atherogenesis. It explores the early lesion, complications of plaques and early detection of plaques. Section II reviews several key methodological issues of B-mode ultrasound imaging and some of the most current data. Quantitative B-mode ultrasound is an established non-invasive tool widely used in large epidemiologic studies and interventional clinical trials of atherosclerosis. The last section addresses the most promising areas of development in vascular imaging. This involves new techniques to evaluate the atherosclerotic bed, to follow atheroma progression/regression and to evaluate vascular mechanics in atherosclerotic arteries. The last chapter places the application of non-invasive imaging in perspective.

Author : Walmor C. de Mello,Michiel J. Janse
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 53,8 Mb
Release : 1997-12-31
Category : Medical
ISBN : 0792380525

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Heart Cell Communication in Health and Disease by Walmor C. de Mello,Michiel J. Janse Pdf

In Heart Cell Communication in Health and Disease an extensive review of different aspects of heart cell communication is presented. The book starts with the fundamental concept that cardiac cells are communicated, and then proceeds to the role of gap junctions in heart development, the molecular biology of gap junctions, the biophysics of the intercellular channels, the control of junctional conductance and the influence of gap junctions on impulse propagation. This is the first time that a single volume has described cell communication in the normal heart and under different pathological conditions such as heart failure, coronary disease, myocardial ischemia and cardiac arrhythmias. In this way the process of cell communication is analyzed at different levels of complexity, providing the reader with a wide view of this field and its relevance to cardiology.

Author : Filippo Crea,Gaetano A. Lanza,Paolo G. Camici
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 44,9 Mb
Release : 2013-08-15
Category : Medical
ISBN : 9788847053670

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Coronary Microvascular Dysfunction by Filippo Crea,Gaetano A. Lanza,Paolo G. Camici Pdf

In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.