Advances In Nucleic Acid Therapeutics

Author : Michael J Gait,Sudhir Agrawal
Publisher : Royal Society of Chemistry
Page : 566 pages
File Size : 51,8 Mb
Release : 2019-02-11
Category : Science
ISBN : 9781788012096

Get Book

Advances in Nucleic Acid Therapeutics by Michael J Gait,Sudhir Agrawal Pdf

The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.

Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
Publisher : Woodhead Publishing
Page : 256 pages
File Size : 44,8 Mb
Release : 2017-04-04
Category : Science
ISBN : 9780081005637

Get Book

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids by Surendra Nimesh,Ramesh Chandra,Nidhi Gupta Pdf

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Author : Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi
Publisher : Academic Press
Page : 474 pages
File Size : 50,7 Mb
Release : 2022-04-10
Category : Science
ISBN : 9780128217399

Get Book

RNA Therapeutics by Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi Pdf

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

Author : Alan M. Gewirtz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 44,5 Mb
Release : 2004-03-25
Category : Medical
ISBN : 9781592597772

Get Book

Nucleic Acid Therapeutics in Cancer by Alan M. Gewirtz Pdf

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
Page : 362 pages
File Size : 55,6 Mb
Release : 2008
Category : Medical
ISBN : 9780854041169

Get Book

Therapeutic Oligonucleotides by Jens Kurreck Pdf

This book provides a compelling overall update on current status of RNA interference

Author : Olga N. Ilinskaya,Hector A. Cabrera-Fuentes,Derek John Hausenloy,Marina A. Zenkova
Publisher : Frontiers Media SA
Page : 251 pages
File Size : 43,5 Mb
Release : 2020-06-04
Category : RNA targeting
ISBN : 9782889637751

Get Book

New Advances in RNA Targeting by Olga N. Ilinskaya,Hector A. Cabrera-Fuentes,Derek John Hausenloy,Marina A. Zenkova Pdf

Author : Akira Murakami
Publisher : Springer
Page : 180 pages
File Size : 46,6 Mb
Release : 2012-07-04
Category : Technology & Engineering
ISBN : 9783642304637

Get Book

Nucleic Acid Drugs by Akira Murakami Pdf

New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz

Author : Subhrangsu Chatterjee,Samit Chattopadhyay
Publisher : Springer Nature
Page : 423 pages
File Size : 52,8 Mb
Release : 2023-05-30
Category : Medical
ISBN : 9789811985201

Get Book

Nucleic Acid Biology and its Application in Human Diseases by Subhrangsu Chatterjee,Samit Chattopadhyay Pdf

This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy. ​

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 54,9 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

Get Book

Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Author : Anonim
Publisher : Academic Press
Page : 286 pages
File Size : 47,5 Mb
Release : 1977-09-13
Category : Medical
ISBN : 0080863086

Get Book

Progress in Nucleic Acid Research and Molecular Biology by Anonim Pdf

Progress in Nucleic Acid Research and Molecular Biology

Author : Anonim
Publisher : ScholarlyEditions
Page : 283 pages
File Size : 53,7 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781481678261

Get Book

Nucleic Acids—Advances in Research and Application: 2013 Edition by Anonim Pdf

Nucleic Acids—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about RNA. The editors have built Nucleic Acids—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about RNA in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nucleic Acids—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Marco Filice,Jesus Ruiz-Cabello
Publisher : Elsevier
Page : 0 pages
File Size : 40,7 Mb
Release : 2019-02-28
Category : Technology & Engineering
ISBN : 012814470X

Get Book

Nucleic Acid Nanotheranostics by Marco Filice,Jesus Ruiz-Cabello Pdf

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient's cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.

Author : Nicolay Ferrari,Rosanne Seguin
Publisher : John Wiley & Sons
Page : 563 pages
File Size : 55,5 Mb
Release : 2018-06-06
Category : Medical
ISBN : 9781119070306

Get Book

Oligonucleotide-Based Drugs and Therapeutics by Nicolay Ferrari,Rosanne Seguin Pdf

A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.

Author : Kun Cheng,Ram I. Mahato
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 43,7 Mb
Release : 2013-04-19
Category : Science
ISBN : 9781118610732

Get Book

Advanced Delivery and Therapeutic Applications of RNAi by Kun Cheng,Ram I. Mahato Pdf

Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.

Author : Eric Wickstrom
Publisher : Wiley-Liss
Page : 296 pages
File Size : 45,6 Mb
Release : 1991-10-18
Category : Medical
ISBN : UOM:39015024791645

Get Book

Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS by Eric Wickstrom Pdf

A wide range of new technology involving a direct genetic approach to the treatment of disease using nucleic acid therapeutics is the main focus of this absorbing book. Provides in-depth coverage of the rapid progress of this new technology, from its theoretical stage to its current position at the verge of experimental applications, along with provocative discussions of the therapeutic implications.