Adverse Events And Oncotargeted Kinase Inhibitors

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Adverse Events and Oncotargeted Kinase Inhibitors

Giuseppe Tridente
Adverse Events and Oncotargeted Kinase Inhibitors Book PDF

Author : Giuseppe Tridente
Publisher : Academic Press
Page : 736 pages
File Size : 46,7 Mb
Release : 2017-05-08
Category : Medical
ISBN : 9780128094457

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Adverse Events and Oncotargeted Kinase Inhibitors by Giuseppe Tridente Pdf

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events. Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib
Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders Book PDF

Author : Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib
Publisher : Elsevier
Page : 606 pages
File Size : 40,9 Mb
Release : 2023-06-06
Category : Medical
ISBN : 9780443186783

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Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders by Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib Pdf

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation Highlights RTK families and the numerous receptors within each subfamily Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Anonim
Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 292 pages
File Size : 51,8 Mb
Release : 2018-11-21
Category : Medical
ISBN : 9780128127384

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Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy by Anonim Pdf

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

FDA's Drug Review Process and the Package Label

Tom Brody
FDA s Drug Review Process and the Package Label Book PDF

Author : Tom Brody
Publisher : Academic Press
Page : 670 pages
File Size : 44,6 Mb
Release : 2017-12-13
Category : Business & Economics
ISBN : 9780128146484

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FDA's Drug Review Process and the Package Label by Tom Brody Pdf

FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label. Reveals strategies for winning FDA approval and for drafting the package label Examples are from one hundred FDA-submissions (NDAs, BLAs) for one hundred different drugs, e.g., for oncology, metabolic diseases, autoimmune diseases, and neurological diseases This book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely, the data from NDAs and BLAs as published on FDA's website at the time FDA grants approval to the drug

Radiation Myelopathy

Timothy Schultheiss
Radiation Myelopathy Book PDF

Author : Timothy Schultheiss
Publisher : Springer Nature
Page : 240 pages
File Size : 54,7 Mb
Release : 2022-08-01
Category : Medical
ISBN : 9783030946586

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Radiation Myelopathy by Timothy Schultheiss Pdf

This book covers every aspect of radiation myelopathy and considers the evidence from all species in which it has been studied. The historical and current understanding of the pathogenesis of this rare but devastating injury is first discussed. The evidence regarding the role of a variety of factors in radiation myelopathy is then reviewed. Readers will find detailed information on the impacts of total radiation dose, radiation volume, dose fractionation, hyper fractionation, age, anatomic level, comorbidities, radiation modifiers, other therapies, and retreatment of the spinal cord. Given the similarity of the pathogenesis of radiation myelopathy in humans and experimental animals, the potential for cross-species modelling of dose response is explored, with attention to relevant species differences. Treatment of the condition is also fully considered. New theories are presented regarding retreatment, small volume response, and the final step in white matter necrosis. The final chapter addresses the medicolegal issues elicited by radiation myelopathy, which is often the result of treatment error. Radiation Myelopathy will be of high value for radiation oncologists, radiation physicists, dosimetrists, biologists, neurologists, medical oncologists, and attorneys.

Renal Disease in Cancer Patients

Kevin W. Finkel,Scott C. Howard
Renal Disease in Cancer Patients Book PDF

Author : Kevin W. Finkel,Scott C. Howard
Publisher : Academic Press
Page : 0 pages
File Size : 51,7 Mb
Release : 2013-10-02
Category : Medical
ISBN : 0124159486

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Renal Disease in Cancer Patients by Kevin W. Finkel,Scott C. Howard Pdf

Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more.

Post-Transplant Lymphoproliferative Disorders

Vikas R. Dharnidharka,Michael Green,Steven A. Webber,Ralf Ulrich Trappe
Post Transplant Lymphoproliferative Disorders Book PDF

Author : Vikas R. Dharnidharka,Michael Green,Steven A. Webber,Ralf Ulrich Trappe
Publisher : Springer
Page : 314 pages
File Size : 50,6 Mb
Release : 2022-02-12
Category : Medical
ISBN : 3030654052

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Post-Transplant Lymphoproliferative Disorders by Vikas R. Dharnidharka,Michael Green,Steven A. Webber,Ralf Ulrich Trappe Pdf

This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information. Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns and residents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD.

Translational Advances in Gynecologic Cancers

Michael Birrer,Lorenzo Ceppi
Translational Advances in Gynecologic Cancers Book PDF

Author : Michael Birrer,Lorenzo Ceppi
Publisher : Academic Press
Page : 354 pages
File Size : 44,6 Mb
Release : 2017-01-25
Category : Medical
ISBN : 9780128037980

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Translational Advances in Gynecologic Cancers by Michael Birrer,Lorenzo Ceppi Pdf

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians Identifies knowledge gaps to inform the next research direction Ties together clinical research and patient needs to help both the researcher and clinician Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

Geriatric Rehabilitation Manual

Timothy L. Kauffman,John O. Barr,Michael L. Moran
Geriatric Rehabilitation Manual Book PDF

Author : Timothy L. Kauffman,John O. Barr,Michael L. Moran
Publisher : Elsevier Health Sciences
Page : 583 pages
File Size : 53,8 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9780443102332

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Geriatric Rehabilitation Manual by Timothy L. Kauffman,John O. Barr,Michael L. Moran Pdf

This manual gives step-by-step guidance on the evaluation and treatment of geriatric diseases and disorders. It covers incidence of disorders, diagnostic tests, associated diagnoses, clinical implications for mobility, and rehabilitation techniques. It offers a broad overview of the effects of aging on all body systems. Special geriatric considerations for laboratory assessment, thermoregulations, and pharmacology are also discussed. This manual is a resource for all training clinicians in geriatric care and is a quick-reference guide for students and practitioners in this field.

Immunotherapy for Gastrointestinal Malignancies

Ramakrishna Vadde,Ganji Purnachandra Nagaraju
Immunotherapy for Gastrointestinal Malignancies Book PDF

Author : Ramakrishna Vadde,Ganji Purnachandra Nagaraju
Publisher : Springer Nature
Page : 257 pages
File Size : 41,9 Mb
Release : 2021-01-31
Category : Medical
ISBN : 9789811564871

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Immunotherapy for Gastrointestinal Malignancies by Ramakrishna Vadde,Ganji Purnachandra Nagaraju Pdf

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies.

Genetics of Bone Biology and Skeletal Disease

Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Genetics of Bone Biology and Skeletal Disease Book PDF

Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Page : 878 pages
File Size : 42,7 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128041987

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Genetics of Bone Biology and Skeletal Disease by Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi Pdf

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Mechanisms and Therapy of Liver Cancer

Anonim
Mechanisms and Therapy of Liver Cancer Book PDF

Author : Anonim
Publisher : Academic Press
Page : 404 pages
File Size : 43,9 Mb
Release : 2021-02-10
Category : Medical
ISBN : 9780128240311

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Mechanisms and Therapy of Liver Cancer by Anonim Pdf

Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications. Provides the latest information on liver cancer research Offers outstanding and original reviews on a range of topics focused on liver cancer Serves as an indispensable reference on liver cancer for researchers and students alike

Brain Metastases from Primary Tumors Volume 1

M. A. Hayat
Brain Metastases from Primary Tumors Volume 1 Book PDF

Author : M. A. Hayat
Publisher : Academic Press
Page : 274 pages
File Size : 44,5 Mb
Release : 2014-04-03
Category : Medical
ISBN : 9780128010952

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Brain Metastases from Primary Tumors Volume 1 by M. A. Hayat Pdf

With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors Volume 1 fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection. The only comprehensive reference detailing the link between primary cancers and brain metastases Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer Provided education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain Documents temporal and gender-related trends in brain metastases from other cancers Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Regulation of Cancer Immune Checkpoints

Jie Xu
Regulation of Cancer Immune Checkpoints Book PDF

Author : Jie Xu
Publisher : Springer Nature
Page : 657 pages
File Size : 51,5 Mb
Release : 2020-03-17
Category : Medical
ISBN : 9789811532665

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Regulation of Cancer Immune Checkpoints by Jie Xu Pdf

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Cardiology Secrets

Glenn N. Levine
Cardiology Secrets Book PDF

Author : Glenn N. Levine
Publisher : Elsevier Health Sciences
Page : 497 pages
File Size : 42,5 Mb
Release : 2014
Category : Medical
ISBN : 9781455748150

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Cardiology Secrets by Glenn N. Levine Pdf

Get quick answers to the most important clinical questions with Cardiology Secrets! Using the popular and trusted Secret Series(R) Q&A format, this easy-to-read cardiology book provides rapid access to the practical, "in-the-trenches" know-how you need to succeed both in practice, and on cardiology board and recertification exams. Get the evidence-based guidance you need to provide optimal care for your patients with cardiac heart diseases. Explore effective solutions to a full range of clinical issues including the general examination, diagnostic procedures, arrhythmias, symptoms and disease states, valvular heart disease, cardiovascular pharmacology, and other medical conditions with associated cardiac involvement. Zero in on key information with bulleted lists, mnemonics, practical tips from the leading cardiologists, and "Key Points" boxes that provide a concise overview of important board-relevant content. Review essential material efficiently with the "Top 100 Secrets in Cardiology" - perfect for last-minute study or self-assessment. Apply all the latest advances in clinical cardiology techniques, technology, and pharmacology. Access the complete text and illustrations online at Expert Consult, fully searchable.