Receptor Tyrosine Kinases In Neurodegenerative And Psychiatric Disorders

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Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib
Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders Book PDF

Author : Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib
Publisher : Elsevier
Page : 606 pages
File Size : 54,8 Mb
Release : 2023-06-06
Category : Medical
ISBN : 9780443186783

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Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders by Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib Pdf

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation Highlights RTK families and the numerous receptors within each subfamily Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

Receptor Tyrosine Kinases: Family and Subfamilies

Deric L. Wheeler,Yosef Yarden
Receptor Tyrosine Kinases Family and Subfamilies Book PDF

Author : Deric L. Wheeler,Yosef Yarden
Publisher : Springer
Page : 878 pages
File Size : 40,7 Mb
Release : 2015-07-31
Category : Science
ISBN : 9783319118888

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Receptor Tyrosine Kinases: Family and Subfamilies by Deric L. Wheeler,Yosef Yarden Pdf

This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.

Treatment-Resistant Depression

Siegfried Kasper,Stuart A. Montgomery
Treatment Resistant Depression Book PDF

Author : Siegfried Kasper,Stuart A. Montgomery
Publisher : John Wiley & Sons
Page : 229 pages
File Size : 43,6 Mb
Release : 2013-02-06
Category : Medical
ISBN : 9781118556733

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Treatment-Resistant Depression by Siegfried Kasper,Stuart A. Montgomery Pdf

Treatment-resistant Depress Successful management of patients with treatment-resistant depression requires a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice. A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of treatment-resistant depression originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine. Biological classification requires identification of genetic risk factors and gene variants have been identified as accounting for 50% of the variance in the clinical outcomes of antidepressant treatments. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, suggests that genetic prediction of treatment resistance could become a widespread clinical reality within a few years. Most patients with treatment-resistant depression will be treated pharmacologically, so three chapters review the latest evidence for pharmacological best practice in switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, explaining that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in treatment-resistant depression and summarizes general therapeutic principles. Essential reading for all psychiatrists managing patients with this distressing disorder.

Cyclin Dependent Kinase 5 (Cdk5)

Nancy Y. Ip,Li-Huei Tsai
Cyclin Dependent Kinase 5 Cdk5 Book PDF

Author : Nancy Y. Ip,Li-Huei Tsai
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 48,7 Mb
Release : 2009-02-28
Category : Medical
ISBN : 9780387788876

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Cyclin Dependent Kinase 5 (Cdk5) by Nancy Y. Ip,Li-Huei Tsai Pdf

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Progressive Brain Disorders in Childhood

Juan M. Pascual
Progressive Brain Disorders in Childhood Book PDF

Author : Juan M. Pascual
Publisher : Cambridge University Press
Page : 507 pages
File Size : 40,5 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9781107042056

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Progressive Brain Disorders in Childhood by Juan M. Pascual Pdf

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Adverse Events and Oncotargeted Kinase Inhibitors

Giuseppe Tridente
Adverse Events and Oncotargeted Kinase Inhibitors Book PDF

Author : Giuseppe Tridente
Publisher : Academic Press
Page : 736 pages
File Size : 44,7 Mb
Release : 2017-05-08
Category : Medical
ISBN : 9780128094457

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Adverse Events and Oncotargeted Kinase Inhibitors by Giuseppe Tridente Pdf

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events. Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Neurobiology of Depression

Francisco Lopez-Munoz,Cecilio Alamo
Neurobiology of Depression Book PDF

Author : Francisco Lopez-Munoz,Cecilio Alamo
Publisher : CRC Press
Page : 531 pages
File Size : 49,9 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781439838495

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Neurobiology of Depression by Francisco Lopez-Munoz,Cecilio Alamo Pdf

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Biased Signaling in Physiology, Pharmacology and Therapeutics

Brian J Arey
Biased Signaling in Physiology Pharmacology and Therapeutics Book PDF

Author : Brian J Arey
Publisher : Elsevier
Page : 316 pages
File Size : 45,6 Mb
Release : 2014-06-05
Category : Medical
ISBN : 9780124115071

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Biased Signaling in Physiology, Pharmacology and Therapeutics by Brian J Arey Pdf

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Protein Kinase Inhibitors

Md. Imtaiyaz Hassan,Saba Noor
Protein Kinase Inhibitors Book PDF

Author : Md. Imtaiyaz Hassan,Saba Noor
Publisher : Academic Press
Page : 832 pages
File Size : 40,8 Mb
Release : 2022-05-19
Category : Science
ISBN : 9780323913492

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Protein Kinase Inhibitors by Md. Imtaiyaz Hassan,Saba Noor Pdf

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development. Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation Examines protein kinase inhibitor drugs in various stages of clinical trials and development Offers methods and protocols for protein kinase inhibitor research studies and drug design and development Includes chapter contributions from international leaders in the field

Hormones of the Limbic System

Anonim
Hormones of the Limbic System Book PDF

Author : Anonim
Publisher : Academic Press
Page : 464 pages
File Size : 49,7 Mb
Release : 2010-07-07
Category : Medical
ISBN : 0123815320

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Hormones of the Limbic System by Anonim Pdf

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones of the limbic system. Longest running series published by Academic Press Contributions by leading international authorities

Molecular Neurology

Stephen Waxman
Molecular Neurology Book PDF

Author : Stephen Waxman
Publisher : Elsevier
Page : 600 pages
File Size : 41,7 Mb
Release : 2010-07-26
Category : Medical
ISBN : 0080546188

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Molecular Neurology by Stephen Waxman Pdf

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

The Benefits of Natural Products for Neurodegenerative Diseases

M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
The Benefits of Natural Products for Neurodegenerative Diseases Book PDF

Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Page : 496 pages
File Size : 45,6 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9783319283838

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The Benefits of Natural Products for Neurodegenerative Diseases by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin Pdf

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Signal Transduction and Human Disease

Toren Finkel,J. Silvio Gutkind
Signal Transduction and Human Disease Book PDF

Author : Toren Finkel,J. Silvio Gutkind
Publisher : John Wiley & Sons
Page : 490 pages
File Size : 43,6 Mb
Release : 2003-07-18
Category : Science
ISBN : 9780471448372

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Signal Transduction and Human Disease by Toren Finkel,J. Silvio Gutkind Pdf

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Neurodegenerative Disorders

Orla Hardiman,Colin P. Doherty
Neurodegenerative Disorders Book PDF

Author : Orla Hardiman,Colin P. Doherty
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 44,6 Mb
Release : 2011-06-15
Category : Medical
ISBN : 9781849960113

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Neurodegenerative Disorders by Orla Hardiman,Colin P. Doherty Pdf

Neurodegenerative Disorders provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions including Alzheimer Disease; Dementia and Cerebrovascular Disease; Parkinson’s Disease; Fronto-Temporal Dementia; Amyotrophic Lateral Sclerosis; Huntington’s Disease; Parkinsonism Plus syndromes and Prion Diseases. Final chapters cover important management issues including the use of palliative care strategies, advance directives and competence. Written by experts in the field internationally Neurodegenerative Disorders is a practical guide for clinicians that will be indispensable for the management of these conditions.

Molecular Mechanisms of Neurodegenerative Diseases

Marie-Francoise Chesselet
Molecular Mechanisms of Neurodegenerative Diseases Book PDF

Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 41,6 Mb
Release : 2000-10-19
Category : Medical
ISBN : 9781592590063

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Molecular Mechanisms of Neurodegenerative Diseases by Marie-Francoise Chesselet Pdf

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.