Aging Mechanisms

Author : Nozomu Mori,Inhee Mook-Jung
Publisher : Springer
Page : 0 pages
File Size : 55,5 Mb
Release : 2019-03-21
Category : Medical
ISBN : 4431566880

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Aging Mechanisms by Nozomu Mori,Inhee Mook-Jung Pdf

This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.

Author : Sara C. Zapico
Publisher : CRC Press
Page : 200 pages
File Size : 40,5 Mb
Release : 2017-03-27
Category : Law
ISBN : 9781315354200

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Mechanisms Linking Aging, Diseases and Biological Age Estimation by Sara C. Zapico Pdf

This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

Author : David R. Riddle
Publisher : CRC Press
Page : 408 pages
File Size : 41,5 Mb
Release : 2007-04-19
Category : Medical
ISBN : 1420005529

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Brain Aging by David R. Riddle Pdf

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Author : Calogero Caruso,Giuseppina Candore
Publisher : Academic Press
Page : 382 pages
File Size : 49,5 Mb
Release : 2021-05-11
Category : Science
ISBN : 9780128227374

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Human Aging by Calogero Caruso,Giuseppina Candore Pdf

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Author : Nozomu Mori,Inhee Mook-Jung
Publisher : Springer
Page : 439 pages
File Size : 44,9 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9784431557630

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Aging Mechanisms by Nozomu Mori,Inhee Mook-Jung Pdf

This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.

Author : Klaus-Günter Collatz,Rajindar S. Sohal
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642708534

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Insect Aging by Klaus-Günter Collatz,Rajindar S. Sohal Pdf

"Leben ist die schonste Erfindung der Natur und der Tod ist ihr Kunstgriff, viel Leben zu haben" . J. W. v. Goethe Life is the most beautiful invention of nature, and death is her device to exhibit most life. The eminent British biologist Sir Vincent B. Wigglesworth noted in 1939 that insects are an ideal medium in which to study all problems of physiology. Many fundamental discoveries in biology, particularly genetics and development, have been made on the basis of studies conducted in insects. Because of their ex treme adaptability and diversity, an appropriate insect model is available for the study of virtually any biological problems. The applicability to other groups, including mammals, of basic studies conducted on insects has helped in the gradual acceptance of the fundamental unity of biochemical principles as a dogma among biologists, as well as among enlightened medical scientists. With the recent upsurge of interest in the study of the aging process, in sects have been increasingly employed not only for the investigation of basic mechanisms of aging, but also to gain insight into the evolution of aging and senescence. If only one aging mechanism exists, it is foreseeable that some in sects, especially Drosophila, will help to unravel its molecular basis. Because of their diversity, existing studies in the gerontology of insects are widely scat tered in various specialized journals. This wealth of existing information has not, as yet, been brought together in a synthesized and comprehensive form.

Author : Nozomu Mori
Publisher : Springer Nature
Page : 429 pages
File Size : 50,7 Mb
Release : 2022-04-28
Category : Medical
ISBN : 9789811679773

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Aging Mechanisms II by Nozomu Mori Pdf

This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

Author : Christian Behl,Christine Ziegler
Publisher : Springer Science & Business Media
Page : 113 pages
File Size : 47,8 Mb
Release : 2013-12-18
Category : Science
ISBN : 9783642451799

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Cell Aging: Molecular Mechanisms and Implications for Disease by Christian Behl,Christine Ziegler Pdf

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Author : Zhao Wang
Publisher : Springer
Page : 282 pages
File Size : 43,6 Mb
Release : 2018-09-19
Category : Science
ISBN : 9789811311178

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Aging and Aging-Related Diseases by Zhao Wang Pdf

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

Author : C.V. Mobbs,P.R. Hof
Publisher : Karger Medical and Scientific Publishers
Page : 204 pages
File Size : 51,9 Mb
Release : 2010-08-12
Category : Medical
ISBN : 9783805595223

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Body Composition and Aging by C.V. Mobbs,P.R. Hof Pdf

Increased adiposity and decreased muscle mass contribute substantially to age-dependent disease and disability. In particular age-related increase in adiposity is quickly becoming a major threat to public health throughout the world. Although the hypothesis that age-related changes in body composition are due to lifestyle choices alone is well accepted, it is a vast oversimplification. This volume reflects the current knowledge in this rapidly developing field of research. The first part of the book discusses the extent to which increased adiposity contributes to age-related diseases and longevity. The 'obesity paradox', describing the protective role of overweight in decreasing mortality while increasing pathology, is covered in depth. Further chapters address specific aspects of the regulation of energy balance during aging, including the effects of changes in food intake. Finally the causes and consequences of loss of muscle mass and age-related osteoporosis are examined.A valuable help for physicians treating elderly patients, this book will also be of great interest to researchers studying energy balance, muscle physiology, bone disease, and other aspects of aging.

Author : Joris Deelen,Alan A. Cohen,Owen Jones
Publisher : Frontiers Media SA
Page : 209 pages
File Size : 51,8 Mb
Release : 2022-03-11
Category : Science
ISBN : 9782889746613

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Mechanisms and Pathways Contributing to the Diversity of Aging across the Tree of Life by Joris Deelen,Alan A. Cohen,Owen Jones Pdf

Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publisher : Springer
Page : 354 pages
File Size : 46,8 Mb
Release : 2015-07-06
Category : Science
ISBN : 9783709112328

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Stem Cell Aging: Mechanisms, Consequences, Rejuvenation by Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian Pdf

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Author : Lev Salnikov
Publisher : Xlibris Corporation
Page : 63 pages
File Size : 44,5 Mb
Release : 2011-04-15
Category : Science
ISBN : 9781462856268

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A New Look at the Mechanisms and Theory of Aging by Lev Salnikov Pdf

This work presents a novel theory of aging. Building on the traditional approach to the function of the genome in multicellular organisms, the author offers an alternative means to the understanding of the fundamental processes governing the function of the cells in the context of the organism as a whole. A distinction is drawn between the causes of aging and the processes that are associated with aging. Drawing on the published experimental data, the author presents his description of the mechanisms of aging. This text is aimed not only at the biologists working on the problem of aging, but also at a broader audience that may be interested in the problems of the biology of aging.

Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 41,5 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

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Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Author : Evandro Fei Fang,Linda Hildegard Bergersen,Brian C. Gilmour
Publisher : Academic Press
Page : 262 pages
File Size : 51,5 Mb
Release : 2022-10-23
Category : Science
ISBN : 9780323916189

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging by Evandro Fei Fang,Linda Hildegard Bergersen,Brian C. Gilmour Pdf

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer’s disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging