Alzheimer S Disease Modernizing Concept Biological Diagnosis And Therapy

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Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy

M.C. Carrillo,H. Hampel
Alzheimer s Disease Modernizing Concept Biological Diagnosis and Therapy Book PDF

Author : M.C. Carrillo,H. Hampel
Publisher : Karger Medical and Scientific Publishers
Page : 200 pages
File Size : 50,5 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783805598033

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Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy by M.C. Carrillo,H. Hampel Pdf

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease

Ghulam Md Ashraf,Athanasios Alexiou
Biological Diagnostic and Therapeutic Advances in Alzheimer s Disease Book PDF

Author : Ghulam Md Ashraf,Athanasios Alexiou
Publisher : Springer Nature
Page : 293 pages
File Size : 52,5 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9789811396366

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Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease by Ghulam Md Ashraf,Athanasios Alexiou Pdf

This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.

Concepts of Alzheimer Disease

Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger
Concepts of Alzheimer Disease Book PDF

Author : Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger
Publisher : JHU Press
Page : 343 pages
File Size : 41,9 Mb
Release : 2003-05-27
Category : Health & Fitness
ISBN : 9780801877155

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Concepts of Alzheimer Disease by Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger Pdf

As the essays in this volume show, conceptualizing dementia has always been a complex process. With contributions from noted professionals in psychiatry, neurology, molecular biology, sociology, history, ethics, and health policy, Concepts of Alzheimer Disease looks at the ways in which Alzheimer disease has been defined in various historical and cultural contexts. The book covers every major development in the field, from the first case described by Alois Alzheimer in 1907 through groundbreaking work on the genetics of the disease. Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.

Early Diagnosis of Alzheimer’s Disease

Leonard F. M. Scinto,Kirk R. Daffner
Early Diagnosis of Alzheimer s Disease Book PDF

Author : Leonard F. M. Scinto,Kirk R. Daffner
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 44,6 Mb
Release : 2000-02-09
Category : Medical
ISBN : 9781592590056

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Early Diagnosis of Alzheimer’s Disease by Leonard F. M. Scinto,Kirk R. Daffner Pdf

Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.

Ayurvedic Herbal Preparations in Neurological Disorders

Murali Muralidhara,Padmanabhan S. Rajini
Ayurvedic Herbal Preparations in Neurological Disorders Book PDF

Author : Murali Muralidhara,Padmanabhan S. Rajini
Publisher : Elsevier
Page : 752 pages
File Size : 44,5 Mb
Release : 2023-08-07
Category : Medical
ISBN : 9780443153969

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Ayurvedic Herbal Preparations in Neurological Disorders by Murali Muralidhara,Padmanabhan S. Rajini Pdf

Ayurvedic Herbal Preparations in Neurological Disorders provides a comprehensive and mechanistic understanding of the therapeutic potential of many ayurvedic herbal preparations in disease management. Examining research data for evidence-based ayurvedic approaches, this volume begins with a focused introduction to major ayurvedic plants, discussing various mechanisms underlying their neuromodulatory potential in preclinical and clinical settings. Major subsets of ayurvedic plants are discussed, including Bacopa monnieri, Centella asiatica, Withania somnifera, and others. This volume outlines the importance of integrative approaches along with existing treatments in the intervention/management of Alzheimer’s disease, Parkinson’s disease, depressive mood disorders, epilepsy, schizophrenia, and more. More than a mere compilation of studies, this volume identifies relevant gaps for future research avenues and encourages interdisciplinary collaboration and sharing of knowledge to together identify the most efficacious ayurvedic approaches. Highlighting recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection, this book is crucial for anyone researching or working in the field of neurological disorder treatment and prevention. Provides a focused introduction to major Ayurvedic plants and their therapeutic potential in the management of neurodegenerative diseases Discusses various mechanisms underlying the neuromodulatory potential of several ayurvedic herbal preparations in preclinical and clinical settings Examines major subsets of ayurvedic plants (e.g., Bacopa monnieri, Centella asiatica, Withaniasomnifera, and others) and potential of several other plants in various neurological disorders Outlines the importance of integrative approaches along with existing treatments in the intervention/management of depressive mood disorders, epilepsy, schizophrenia, and more Highlights recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection

Behavioral Medicine and Integrated Care

Melanie P. Duckworth,William T. O'Donohue
Behavioral Medicine and Integrated Care Book PDF

Author : Melanie P. Duckworth,William T. O'Donohue
Publisher : Springer
Page : 418 pages
File Size : 44,9 Mb
Release : 2018-10-12
Category : Psychology
ISBN : 9783319930039

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Behavioral Medicine and Integrated Care by Melanie P. Duckworth,William T. O'Donohue Pdf

This evidence-to-practice volume deftly analyzes the processes and skills of integrating mental healthcare with primary care, using multiple perspectives to address challenges that often derail these joint efforts. Experts across integrative medicine offer accessible blueprints for smoothly implementing data-based behavioral interventions, from disease management strategies to treatment of psychological problems, into patient-centered, cost-effective integrated care. Coverage highlights training and technology issues, key healthcare constructs that often get lost in translation, and other knowledge necessary to create systems that are rooted in—and contribute to—a robust evidence base. Contributors also provide step-by-step guidelines for integrating behavioral health care delivery in treating cancer, dementia, and chronic pain. Among the topics covered: The epidemiology of medical diseases and associated behavioral risk factors. Provider training: recognizing the relevance of behavioral medicine and the importance of behavioral health consultations and referrals. Screening for behavioral health problems in adult primary care. Health care transformation: the electronic health record. Meeting the care needs of patients with multiple medical conditions. Smoking cessation in the context of integrated care. This depth of clinical guidance makes Behavioral Medicine and Integrated Care an essential reference for practitioners on all sides of the equation, including health psychologists and other professionals in health promotion, disease prevention, psychotherapy and counseling, and primary care medicine.

Handbook of Prevention and Alzheimer’s Disease

C.A. Raji,Y. Leng,J.W. Ashford
Handbook of Prevention and Alzheimer s Disease Book PDF

Author : C.A. Raji,Y. Leng,J.W. Ashford
Publisher : IOS Press
Page : 674 pages
File Size : 40,9 Mb
Release : 2024-02-20
Category : Medical
ISBN : 9781643684932

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Handbook of Prevention and Alzheimer’s Disease by C.A. Raji,Y. Leng,J.W. Ashford Pdf

It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of modifiable risk factors associated with the disease has been present from the outset. Thus, the idea of preventing AD is not new, with reference to strategies noted as early as the 1990s. This subfield of AD research has matured in recent years, with the number of modifiable risk factors – the AD preventome – rising from the 7 initially identified to the current 12, with an estimated contribution to dementia cases worldwide of about 40%. This book, the Handbook of Prevention and Alzheimer’s Disease, introduces physicians, scientists, and other stakeholders to this subfield of AD research. It investigates the AD preventome, which will continue to expand as the understanding of new factors and related biomarkers is refined. Optimizing this preventome leads to an improvement in overall brain health, an outcome which reduces the risk of developing AD and improves quality of life. The book goes on to examine other domains of prevention, from vascular risk factors to social engagement and from sleep health to spirituality. If the journey to end AD can be likened to a long and arduous challenge, understanding every possible part of the overall toolkit of approaches for disease prevention and intervention is essential. Together with its companion volume on intervention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: White matter tracts showing sex differences in connectivity in men versus women as a function of increasing body mass index. Reprinted with permission from Rahmani F, Wang Q, McKay NS, Keefe S, Hantler N, Hornbeck R, Wang Y, Hassenstab J, Schindler S, Xiong C, Morris JC, Benzinger TLS, Raji CA. Sex-Specific Patterns of Body Mass Index Relationship with White Matter Connectivity. J Alzheimers Dis. 2022;86(4):1831-1848. doi: 10.3233/JAD-215329. PMID: 35180116; PMCID: PMC9108572.

Stepping Stones to Living Well with Dysphagia

Julie A. Y. Cichero,P. Clavé
Stepping Stones to Living Well with Dysphagia Book PDF

Author : Julie A. Y. Cichero,P. Clavé
Publisher : Karger Medical and Scientific Publishers
Page : 155 pages
File Size : 54,7 Mb
Release : 2012
Category : Medical
ISBN : 9783318021134

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Stepping Stones to Living Well with Dysphagia by Julie A. Y. Cichero,P. Clavé Pdf

A multidisciplinary approach to diagnosis, treatment and care Oropharyngeal dysphagia is a major complaint among many patients suffering from neurological diseases as well as in the elderly. Its severity ranges from moderate difficulty to complete inability to swallow, and it may give rise to clinically relevant complications such as aspiration pneumonia, malnutrition and/or dehydration, impaired quality of life, and death. However, despite its high prevalence and even though it would be very cost-effective to avoid complications by adequate treatment, dysphagia is still severely underdiagnosed. The contributions in this book present and discuss state-of-the-art diagnostic methods, treatment, and care of dysphagia patients, putting special emphasis on a multidisciplinary approach. A variety of clinical specialists will find this publication a most valuable addition to their library, including nurses, speech-language pathologists, dieticians, nutritionists, gastroenterologists and related specialties.

Oxford Textbook of Neuropsychiatry

Niruj Agrawal,Rafey Faruqui,Mayur Bodani
Oxford Textbook of Neuropsychiatry Book PDF

Author : Niruj Agrawal,Rafey Faruqui,Mayur Bodani
Publisher : Oxford University Press, USA
Page : 601 pages
File Size : 45,8 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9780198757139

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Oxford Textbook of Neuropsychiatry by Niruj Agrawal,Rafey Faruqui,Mayur Bodani Pdf

New from Oxford Textbooks in Psychiatry, the Oxford Textbook of Neuropsychiatry bridges the gap between general psychiatric textbooks and reference texts in neuropsychiatry. Divided into four sections, it covers core knowledge and skills for practice in all psychiatric disciplines, with key information for training in neuropsychiatry.

Biological Aspects of Suicidal Behavior

W.P. Kaschka,D. Rujescu
Biological Aspects of Suicidal Behavior Book PDF

Author : W.P. Kaschka,D. Rujescu
Publisher : Karger Medical and Scientific Publishers
Page : 170 pages
File Size : 54,8 Mb
Release : 2015-10-19
Category : Psychology
ISBN : 9783318055849

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Biological Aspects of Suicidal Behavior by W.P. Kaschka,D. Rujescu Pdf

Suicide is one of the most important causes of death in modern societies. To develop more effective preventive measures, we have to be aware of and learn more about its neurobiological foundations. In recent years, the tools of modern neurosciences have increasingly been utilized to characterize the pathophysiology of complex human behaviors such as suicide. To improve suicide risk assessment and suicide prevention, a better understanding of its pathophysiology is crucial. This includes research from a variety of disciplines such as neuropsychological, psychosocial and cultural studies but also findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. Important results have, for example, been obtained in the field of gene-environment interaction and suicidal behavior. We have just begun to understand how early-life adversity may increase suicide risk by epigenetic mechanisms. Based on such insights, novel therapeutic interventions and preventive measures can be developed. Furthermore, a better understanding of the pathophysiological mechanisms involved in suicidal behavior could reveal the mechanism of compounds like lithium salts. In this book, suicidal behavior and its prevention is discussed by international experts in the light of the most recent results from a broad spectrum of neurosciences.

Handbook of Intervention and Alzheimer’s Disease

C.A. Raji,Y. Leng,J.W. Ashford
Handbook of Intervention and Alzheimer s Disease Book PDF

Author : C.A. Raji,Y. Leng,J.W. Ashford
Publisher : IOS Press
Page : 768 pages
File Size : 51,6 Mb
Release : 2024-02-22
Category : Medical
ISBN : 9781643685014

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Handbook of Intervention and Alzheimer’s Disease by C.A. Raji,Y. Leng,J.W. Ashford Pdf

It is almost 120 years since Alzheimer’s disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer’s Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer’s disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.

Medicinal Chemistry Approaches to Personalized Medicine

Karen Lackey,Bruce Roth
Medicinal Chemistry Approaches to Personalized Medicine Book PDF

Author : Karen Lackey,Bruce Roth
Publisher : John Wiley & Sons
Page : 393 pages
File Size : 41,6 Mb
Release : 2013-11-22
Category : Science
ISBN : 9783527677276

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Medicinal Chemistry Approaches to Personalized Medicine by Karen Lackey,Bruce Roth Pdf

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Proteomics and Metabolomics in Psychiatry

D. Martins-de-Souza
Proteomics and Metabolomics in Psychiatry Book PDF

Author : D. Martins-de-Souza
Publisher : Karger Medical and Scientific Publishers
Page : 152 pages
File Size : 51,6 Mb
Release : 2014-05-23
Category : Medical
ISBN : 9783318026009

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Proteomics and Metabolomics in Psychiatry by D. Martins-de-Souza Pdf

This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

The American Psychiatric Association Publishing Textbook of Psychosomatic Medicine and Consultation-Liaison Psychiatry, Third Edition

James L. Levenson, M.D.
The American Psychiatric Association Publishing Textbook of Psychosomatic Medicine and Consultation Liaison Psychiatry Third Edition Book PDF

Author : James L. Levenson, M.D.
Publisher : American Psychiatric Pub
Page : 1596 pages
File Size : 52,9 Mb
Release : 2018-08-06
Category : Consultation-liaison psychiatry
ISBN : 9781615371365

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The American Psychiatric Association Publishing Textbook of Psychosomatic Medicine and Consultation-Liaison Psychiatry, Third Edition by James L. Levenson, M.D. Pdf

Preceded by American Psychiatric Publishing textbook of psychosomatic medicine: psychiatric care of the medically ill / edited by James L. Levenson. 2nd ed. 2011.

Preventing Alzheimer's Disease

National Institutes National Institutes oF Health,National Institute National Institute on Aging
Preventing Alzheimer s Disease Book PDF

Author : National Institutes National Institutes oF Health,National Institute National Institute on Aging
Publisher : Createspace Independent Publishing Platform
Page : 28 pages
File Size : 53,5 Mb
Release : 2017-02-16
Category : Electronic
ISBN : 1543146074

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Preventing Alzheimer's Disease by National Institutes National Institutes oF Health,National Institute National Institute on Aging Pdf

This booklet summarizes what scientists have learned so far and where research is headed. There is no definitive evidence yet about what can prevent Alzheimer's or age-related cognitive decline. What we do know is that a healthy lifestyle-one that includes a healthy diet, physical activity, appropriate weight, and no smoking-can maintain and improve overall health and well-being. Making healthy choices can also lower the risk of certain chronic diseases, like heart disease and diabetes, and scientists are very interested in the possibility that a healthy lifestyle might have a beneficial effect on Alzheimer's as well. In the meantime, as research continues to pinpoint what works to prevent Alzheimer's, people of all ages can benefit from taking positive steps to get and stay healthy.